JPS62161768A - ３（２ｈ）―ピリダジノン誘導体及びこれを含む薬剤組成物 - Google Patents

３（２ｈ）―ピリダジノン誘導体及びこれを含む薬剤組成物

Info

Publication number
JPS62161768A
JPS62161768A JP61257138A JP25713886A JPS62161768A JP S62161768 A JPS62161768 A JP S62161768A JP 61257138 A JP61257138 A JP 61257138A JP 25713886 A JP25713886 A JP 25713886A JP S62161768 A JPS62161768 A JP S62161768A
Authority
JP
Japan
Prior art keywords
group
substituted
unsubstituted
general formula
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP61257138A
Other languages
English (en)
Japanese (ja)
Other versions
JPS641475B2 (enExample
Inventor
エンドレ　カーストレイネル
ジョルジ　ラブロツキー
ナーンドル　マック
ラースロー　ヤスリツ
ペーテル　マーチュシュ
ジョルジ　チェフ
イルディコー　プリブス
クラーラ　ツアコー
エステル　ディエシュレル
イシュトヴァーン　エレケシュ
ラースロー　カウフェル
マーリア　クハール
ユディト　キンチェッシィ
ユディト　コサーリィ
ヂオェンヂィ　ナヂィ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt, Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Nyrt
Publication of JPS62161768A publication Critical patent/JPS62161768A/ja
Publication of JPS641475B2 publication Critical patent/JPS641475B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP61257138A 1985-10-30 1986-10-30 ３（２ｈ）―ピリダジノン誘導体及びこれを含む薬剤組成物 Granted JPS62161768A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU2251-4155/85 1985-10-30
HU854155A HU195645B (en) 1985-10-30 1985-10-30 Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same

Publications (2)

Publication Number Publication Date
JPS62161768A true JPS62161768A (ja) 1987-07-17
JPS641475B2 JPS641475B2 (enExample) 1989-01-11

Family

ID=10967128

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61257138A Granted JPS62161768A (ja) 1985-10-30 1986-10-30 ３（２ｈ）―ピリダジノン誘導体及びこれを含む薬剤組成物

Country Status (9)

Country Link
US (1) US4826845A (enExample)
EP (1) EP0220735B1 (enExample)
JP (1) JPS62161768A (enExample)
AT (1) ATE89558T1 (enExample)
AU (1) AU589698B2 (enExample)
CA (1) CA1317598C (enExample)
DE (1) DE3688450T2 (enExample)
ES (1) ES2058054T3 (enExample)
HU (1) HU195645B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006316064A (ja) * 1995-05-29 2006-11-24 Ivax Drug Research Inst Ltd ３（２ｈ）−ピリダジノン誘導体及びこれら化合物の使用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
GB9015764D0 (en) * 1990-07-18 1990-09-05 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
CN1038249C (zh) * 1991-08-28 1998-05-06 罗姆和哈斯公司 含有二氢哒嗪酮及其相关化合物的杀菌组合物
JPH11508267A (ja) * 1995-06-26 1999-07-21 藤沢薬品工業株式会社 ピラゾール化合物および医薬組成物
US6447821B1 (en) * 1996-05-30 2002-09-10 Warner-Lambert Company Sugar coated products and process for preparing the same
EP4076456B1 (en) * 2019-12-19 2024-05-01 Université de Strasbourg Sigma-1 receptor ligands and therapeutic uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5728054A (en) * 1980-07-29 1982-02-15 Morishita Seiyaku Kk Pyridazinone derivative

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT204560B (de) 1957-12-14 1959-07-25 Chemie Linz Ag Verfahren zur Herstellung von neuen Pyridazinderivaten
US2938902A (en) 1959-04-24 1960-05-31 American Cyanamid Co Novel pyridazinones and methods of preparing same
FR5027M (enExample) * 1966-01-25 1967-04-24
US3658814A (en) * 1970-03-17 1972-04-25 Sandoz Ag 2-(omega-chloroalkyl)-6-aryl substituted-4 5-dihydropyridazin(2h)-3-one
BE752074A (en) * 1970-06-16 1970-12-16 Sandoz Sa Antiinflammatory pyridazines
BE791098A (fr) * 1971-11-10 1973-05-08 Sandoz Sa Nouveaux derives de la pyridazine, leur preparation et leur applicationcomme medicaments
US4304777A (en) * 1979-08-30 1981-12-08 Sterling Drug Inc. 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics
US4298609A (en) * 1979-08-30 1981-11-03 Sterling Drug Inc. 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their preparation and use as blood pressure lowering agents
JPS5742676A (en) * 1980-08-29 1982-03-10 Morishita Seiyaku Kk Pyridazinone derivative
JPS58146571A (ja) * 1982-02-25 1983-09-01 Morishita Seiyaku Kk ウレア誘導体およびその製造法
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
US4521416A (en) * 1983-03-22 1985-06-04 Warner-Lambert Company 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5728054A (en) * 1980-07-29 1982-02-15 Morishita Seiyaku Kk Pyridazinone derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006316064A (ja) * 1995-05-29 2006-11-24 Ivax Drug Research Inst Ltd ３（２ｈ）−ピリダジノン誘導体及びこれら化合物の使用

Also Published As

Publication number Publication date
JPS641475B2 (enExample) 1989-01-11
ES2058054T3 (es) 1994-11-01
HUT43047A (en) 1987-09-28
AU589698B2 (en) 1989-10-19
US4826845A (en) 1989-05-02
ATE89558T1 (de) 1993-06-15
CA1317598C (en) 1993-05-11
AU6449686A (en) 1987-05-07
HU195645B (en) 1988-06-28
EP0220735A3 (en) 1988-06-15
DE3688450T2 (de) 1993-09-09
DE3688450D1 (de) 1993-06-24
EP0220735B1 (en) 1993-05-19
EP0220735A2 (en) 1987-05-06

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