JPS6168426A - 低フエニルアラニンペプチド混合物の製造法 - Google Patents
低フエニルアラニンペプチド混合物の製造法Info
- Publication number
- JPS6168426A JPS6168426A JP59192000A JP19200084A JPS6168426A JP S6168426 A JPS6168426 A JP S6168426A JP 59192000 A JP59192000 A JP 59192000A JP 19200084 A JP19200084 A JP 19200084A JP S6168426 A JPS6168426 A JP S6168426A
- Authority
- JP
- Japan
- Prior art keywords
- phenylalanine
- low
- amino acid
- membrane
- aromatic amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 title claims abstract description 45
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000012528 membrane Substances 0.000 claims abstract description 35
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 20
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 20
- -1 aromatic amino acid Chemical class 0.000 claims abstract description 19
- 239000000126 substance Substances 0.000 claims abstract description 16
- 238000000909 electrodialysis Methods 0.000 claims abstract description 13
- 238000001223 reverse osmosis Methods 0.000 claims abstract description 12
- 238000005342 ion exchange Methods 0.000 claims abstract description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 10
- 108010059378 Endopeptidases Proteins 0.000 claims abstract description 7
- 102000005593 Endopeptidases Human genes 0.000 claims abstract description 7
- 102000018389 Exopeptidases Human genes 0.000 claims abstract description 7
- 108010091443 Exopeptidases Proteins 0.000 claims abstract description 7
- 229920001184 polypeptide Polymers 0.000 claims abstract description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 230000003204 osmotic effect Effects 0.000 claims description 4
- 238000001179 sorption measurement Methods 0.000 claims description 4
- 150000001768 cations Chemical class 0.000 claims description 3
- 150000001450 anions Chemical class 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 abstract description 23
- 238000000034 method Methods 0.000 abstract description 20
- 235000019640 taste Nutrition 0.000 abstract description 10
- 201000011252 Phenylketonuria Diseases 0.000 abstract description 8
- 235000018102 proteins Nutrition 0.000 description 16
- 150000003839 salts Chemical class 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 235000019750 Crude protein Nutrition 0.000 description 4
- 108090000942 Lactalbumin Proteins 0.000 description 4
- 102000004407 Lactalbumin Human genes 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 102000005367 Carboxypeptidases Human genes 0.000 description 2
- 108010006303 Carboxypeptidases Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 108010068370 Glutens Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 108010059712 Pronase Proteins 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000010612 desalination reaction Methods 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 229930192033 plastin Natural products 0.000 description 2
- 108010049148 plastin Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 208000016670 Disorder of phenylalanine metabolism Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102100033067 Growth factor receptor-bound protein 2 Human genes 0.000 description 1
- 108091009389 Growth factor receptor-bound protein 2 Proteins 0.000 description 1
- 102000008192 Lactoglobulins Human genes 0.000 description 1
- 108010060630 Lactoglobulins Proteins 0.000 description 1
- 108010070551 Meat Proteins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 102000005686 Serum Globulins Human genes 0.000 description 1
- 108010045362 Serum Globulins Proteins 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 235000019643 salty taste Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59192000A JPS6168426A (ja) | 1984-09-12 | 1984-09-12 | 低フエニルアラニンペプチド混合物の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59192000A JPS6168426A (ja) | 1984-09-12 | 1984-09-12 | 低フエニルアラニンペプチド混合物の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6168426A true JPS6168426A (ja) | 1986-04-08 |
| JPH0254070B2 JPH0254070B2 (en, 2012) | 1990-11-20 |
Family
ID=16283936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59192000A Granted JPS6168426A (ja) | 1984-09-12 | 1984-09-12 | 低フエニルアラニンペプチド混合物の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6168426A (en, 2012) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990001023A1 (en) * | 1988-07-19 | 1990-02-08 | American Biogenetics Corporation | Method for solubilizing keratinaceous materials using alkaline hydrogen peroxide solution |
| WO1990013228A1 (en) * | 1989-05-12 | 1990-11-15 | Otsuka Pharmaceutical Co., Ltd. | Oligopeptide mixture and composition containing the same |
| EP0799577A4 (en) * | 1994-10-14 | 1999-02-24 | Morinaga Milk Industry Co Ltd | Peptide mixture and products thereof |
| JP2003092996A (ja) * | 2001-09-25 | 2003-04-02 | Yaizu Suisankagaku Industry Co Ltd | イミダゾールジペプチド類含有組成物の製造方法 |
| CN106566858A (zh) * | 2016-10-19 | 2017-04-19 | 重庆大学 | 一种制备高支低芳寡肽的方法 |
| CN112080542A (zh) * | 2020-09-21 | 2020-12-15 | 江南大学 | 一种低苯丙氨酸蛋清蛋白肽的制备方法 |
| CN113785972A (zh) * | 2021-09-17 | 2021-12-14 | 江苏冬泽特医食品有限公司 | 用于罕见病苯丙酮尿症的营养粉、制备方法及用途 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3149377A1 (en) | 2019-08-02 | 2021-02-11 | Ajinomoto Co., Inc. | Method for producing glycomacropeptide |
-
1984
- 1984-09-12 JP JP59192000A patent/JPS6168426A/ja active Granted
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990001023A1 (en) * | 1988-07-19 | 1990-02-08 | American Biogenetics Corporation | Method for solubilizing keratinaceous materials using alkaline hydrogen peroxide solution |
| WO1990013228A1 (en) * | 1989-05-12 | 1990-11-15 | Otsuka Pharmaceutical Co., Ltd. | Oligopeptide mixture and composition containing the same |
| EP0799577A4 (en) * | 1994-10-14 | 1999-02-24 | Morinaga Milk Industry Co Ltd | Peptide mixture and products thereof |
| JP2003092996A (ja) * | 2001-09-25 | 2003-04-02 | Yaizu Suisankagaku Industry Co Ltd | イミダゾールジペプチド類含有組成物の製造方法 |
| CN106566858A (zh) * | 2016-10-19 | 2017-04-19 | 重庆大学 | 一种制备高支低芳寡肽的方法 |
| CN106566858B (zh) * | 2016-10-19 | 2021-02-12 | 重庆大学 | 一种制备高支低芳寡肽的方法 |
| CN112080542A (zh) * | 2020-09-21 | 2020-12-15 | 江南大学 | 一种低苯丙氨酸蛋清蛋白肽的制备方法 |
| CN112080542B (zh) * | 2020-09-21 | 2022-03-04 | 江南大学 | 一种低苯丙氨酸蛋清蛋白肽的制备方法 |
| CN113785972A (zh) * | 2021-09-17 | 2021-12-14 | 江苏冬泽特医食品有限公司 | 用于罕见病苯丙酮尿症的营养粉、制备方法及用途 |
| CN113785972B (zh) * | 2021-09-17 | 2023-10-24 | 江苏冬泽特医食品有限公司 | 用于罕见病苯丙酮尿症的营养粉、制备方法及用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0254070B2 (en, 2012) | 1990-11-20 |
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