JPS6150979A - ピリジン誘導体およびその製造法 - Google Patents

ピリジン誘導体およびその製造法

Info

Publication number
JPS6150979A
JPS6150979A JP59171070A JP17107084A JPS6150979A JP S6150979 A JPS6150979 A JP S6150979A JP 59171070 A JP59171070 A JP 59171070A JP 17107084 A JP17107084 A JP 17107084A JP S6150979 A JPS6150979 A JP S6150979A
Authority
JP
Japan
Prior art keywords
compound
formula
formulas
solvent
gastric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59171070A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0475914B2 (fr
Inventor
Akira Nohara
野原　昭
Yoshitaka Maki
牧　良孝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP59171070A priority Critical patent/JPS6150979A/ja
Priority to DE8585305459T priority patent/DE3585652D1/de
Priority to AT85305459T priority patent/ATE73796T1/de
Priority to EP19850305459 priority patent/EP0175464B1/fr
Priority to CA000488661A priority patent/CA1256878A/fr
Publication of JPS6150979A publication Critical patent/JPS6150979A/ja
Priority to US07/016,951 priority patent/US4727150A/en
Publication of JPH0475914B2 publication Critical patent/JPH0475914B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP59171070A 1984-08-16 1984-08-16 ピリジン誘導体およびその製造法 Granted JPS6150979A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP59171070A JPS6150979A (ja) 1984-08-16 1984-08-16 ピリジン誘導体およびその製造法
DE8585305459T DE3585652D1 (de) 1984-08-16 1985-07-31 Benzimidazolderivate und deren herstellung.
AT85305459T ATE73796T1 (de) 1984-08-16 1985-07-31 Benzimidazolderivate und deren herstellung.
EP19850305459 EP0175464B1 (fr) 1984-08-16 1985-07-31 Dérivés de benzimidazole et leur préparation
CA000488661A CA1256878A (fr) 1984-08-16 1985-08-14 Derives de benzimidazole, et leur production
US07/016,951 US4727150A (en) 1984-08-16 1987-02-20 Pyridyl methylsulfinyl benzimidazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59171070A JPS6150979A (ja) 1984-08-16 1984-08-16 ピリジン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
JPS6150979A true JPS6150979A (ja) 1986-03-13
JPH0475914B2 JPH0475914B2 (fr) 1992-12-02

Family

ID=15916472

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59171070A Granted JPS6150979A (ja) 1984-08-16 1984-08-16 ピリジン誘導体およびその製造法

Country Status (6)

Country Link
US (1) US4727150A (fr)
EP (1) EP0175464B1 (fr)
JP (1) JPS6150979A (fr)
AT (1) ATE73796T1 (fr)
CA (1) CA1256878A (fr)
DE (1) DE3585652D1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989000566A1 (fr) * 1987-07-21 1989-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Composes de pyridine et leurs utilisations en medecine
WO2007105551A1 (fr) 2006-03-10 2007-09-20 Arigen Pharmaceuticals, Inc. nouveau derive de pyridine ayant une activite contre helicobacter pylori
WO2008075462A1 (fr) 2006-12-18 2008-06-26 Arigen Pharmaceuticals, Inc. Agent éradiquant helicobacter pylori, ayant une activité inhibitrice sur la sécrétion de l'acide gastrique
WO2010116740A1 (fr) 2009-04-09 2010-10-14 アリジェン製薬株式会社 Dérivé de thiopyridine, et composition pharmaceutique le contenant et ayant une action anti-helicobacter pylori

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
US6749864B2 (en) 1986-02-13 2004-06-15 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
US5433959A (en) 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
CA1327010C (fr) * 1986-02-13 1994-02-15 Tadashi Makino Compositions pharmaceutiques contenant un compose anti-ulcereux de type benzimidazole et sa production
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
EG19302A (en) * 1988-12-22 1994-11-30 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804628D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New compounds
GR1001241B (el) * 1989-05-19 1993-06-30 Byk Gulden Lomberg Chem Fab Μεθοδος αλκυλιωσεως.
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
DE69132082T2 (de) 1990-10-17 2000-08-31 Takeda Chemical Industries Ltd Pyridin-Derivate, Verfahren zu deren Herstellung und Anwendung
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
WO2006030936A1 (fr) 2004-09-13 2006-03-23 Takeda Pharmaceutical Company Limited Procede et appareil destines a produire un compose oxyde
WO2009116072A2 (fr) * 2008-02-08 2009-09-24 Ipca Laboratories Limited Procédé de préparation de composés de pyridinylméthylsulphinyl benzimidazole et intermédiaires de pyridine
KR101444070B1 (ko) * 2009-07-30 2014-09-26 에스케이플래닛 주식회사 저장장치에서 호스트 단말의 메모리 이용 시스템 및 방법, 그 호스트 단말 및 저장장치, 이를 위한 기록매체
CN104019635B (zh) * 2014-06-19 2015-05-27 上海慈瑞医药科技有限公司 一种兰索拉唑原料药化合物及其干燥工艺

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2134523A (en) * 1983-02-11 1984-08-15 Haessle Ab Novel pharmacologically active compounds
JPS59206379A (ja) * 1983-05-03 1984-11-22 ビク・グルデン・ロムベルク・ヘミツシエ・フアブリク・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング フルオルアルコキシ化合物及びこれを含有する胃酸分泌抑制剤
JPS6122079A (ja) * 1984-06-16 1986-01-30 ビク・グルデン・ロムベルク・ヘミツシエ・フアブリク・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング ジアルコキシピリジン及びそれを含有する薬剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2134523A (en) * 1983-02-11 1984-08-15 Haessle Ab Novel pharmacologically active compounds
JPS59206379A (ja) * 1983-05-03 1984-11-22 ビク・グルデン・ロムベルク・ヘミツシエ・フアブリク・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング フルオルアルコキシ化合物及びこれを含有する胃酸分泌抑制剤
JPS6122079A (ja) * 1984-06-16 1986-01-30 ビク・グルデン・ロムベルク・ヘミツシエ・フアブリク・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング ジアルコキシピリジン及びそれを含有する薬剤

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989000566A1 (fr) * 1987-07-21 1989-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Composes de pyridine et leurs utilisations en medecine
WO2007105551A1 (fr) 2006-03-10 2007-09-20 Arigen Pharmaceuticals, Inc. nouveau derive de pyridine ayant une activite contre helicobacter pylori
WO2008075462A1 (fr) 2006-12-18 2008-06-26 Arigen Pharmaceuticals, Inc. Agent éradiquant helicobacter pylori, ayant une activité inhibitrice sur la sécrétion de l'acide gastrique
JP5097126B2 (ja) * 2006-12-18 2012-12-12 アリジェン製薬株式会社 胃酸分泌抑制作用を併せ持つヘリコバクター・ピロリ除菌剤
KR101283682B1 (ko) * 2006-12-18 2013-07-08 링크 제노믹스 가부시키가이샤 위산 분비 억제작용을 지닌 헬리코박터 피로리 제균제
US8778975B2 (en) 2006-12-18 2014-07-15 Link Geonomics, Inc. Helicobacter pylori eradicating agent having inhibitory activity on gastric acid secretion
WO2010116740A1 (fr) 2009-04-09 2010-10-14 アリジェン製薬株式会社 Dérivé de thiopyridine, et composition pharmaceutique le contenant et ayant une action anti-helicobacter pylori
JP5543432B2 (ja) * 2009-04-09 2014-07-09 リンク・ジェノミクス株式会社 ピリジンチオ誘導体及びそれを含有する抗ヘリコバクター・ピロリ作用を有する医薬組成物

Also Published As

Publication number Publication date
DE3585652D1 (de) 1992-04-23
EP0175464A1 (fr) 1986-03-26
JPH0475914B2 (fr) 1992-12-02
ATE73796T1 (de) 1992-04-15
EP0175464B1 (fr) 1992-03-18
US4727150A (en) 1988-02-23
CA1256878A (fr) 1989-07-04

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term