JPS6147418A - ヒアルロン酸含有胃粘膜保護剤 - Google Patents
ヒアルロン酸含有胃粘膜保護剤Info
- Publication number
- JPS6147418A JPS6147418A JP16777584A JP16777584A JPS6147418A JP S6147418 A JPS6147418 A JP S6147418A JP 16777584 A JP16777584 A JP 16777584A JP 16777584 A JP16777584 A JP 16777584A JP S6147418 A JPS6147418 A JP S6147418A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- hyaluronic acid
- protein
- sample
- lecithin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 59
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 58
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 57
- 230000036541 health Effects 0.000 title claims abstract description 43
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- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 52
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 44
- 235000010445 lecithin Nutrition 0.000 claims abstract description 44
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- 150000003839 salts Chemical class 0.000 claims abstract description 42
- 239000003795 chemical substances by application Substances 0.000 claims description 45
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 34
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 34
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 34
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- 238000002360 preparation method Methods 0.000 abstract description 4
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 abstract 2
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 34
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 24
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- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 14
- 238000007796 conventional method Methods 0.000 description 14
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- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 13
- 102000002322 Egg Proteins Human genes 0.000 description 13
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- 235000014103 egg white Nutrition 0.000 description 13
- 210000000969 egg white Anatomy 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 235000012000 cholesterol Nutrition 0.000 description 12
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- 239000007864 aqueous solution Substances 0.000 description 11
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- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 8
- 230000007059 acute toxicity Effects 0.000 description 8
- 231100000403 acute toxicity Toxicity 0.000 description 8
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 8
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical group OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 5
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 1
- 238000009933 burial Methods 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229940021652 thiamine hydrochloride 100 mg Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16777584A JPS6147418A (ja) | 1984-08-13 | 1984-08-13 | ヒアルロン酸含有胃粘膜保護剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16777584A JPS6147418A (ja) | 1984-08-13 | 1984-08-13 | ヒアルロン酸含有胃粘膜保護剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4322870A Division JPH0662425B2 (ja) | 1992-12-02 | 1992-12-02 | ヒアルロン酸含有血中脂質低下剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6147418A true JPS6147418A (ja) | 1986-03-07 |
| JPH0534341B2 JPH0534341B2 (enExample) | 1993-05-21 |
Family
ID=15855875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16777584A Granted JPS6147418A (ja) | 1984-08-13 | 1984-08-13 | ヒアルロン酸含有胃粘膜保護剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6147418A (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000001394A1 (en) * | 1998-07-06 | 2000-01-13 | Fidia Advanced Biopolymers S.R.L. | Biocompatible and biodegradable compositions containing hyaluronic acid and the derivatives thereof for the treatment of ulcers in the digestive apparatus |
| WO2000007577A3 (de) * | 1998-08-06 | 2000-10-26 | Wolfgang Stremmel | Phosphatidylcholin als arzneimittel mit schleimhautschützender wirkung |
| US6566346B2 (en) | 2001-03-27 | 2003-05-20 | Q.P. Corporation | Oral skin improving agent, skin improving method, and food composition for improving skin |
| JP2009538287A (ja) * | 2006-05-26 | 2009-11-05 | アルテルゴン エス．エイ． | 低粘度グリコサミノグリカンで構成される組成及び該組成の間質性膀胱炎の治療での使用 |
| WO2010136872A2 (en) | 2009-05-25 | 2010-12-02 | Pharcoterm S.R.L. | Use of a glycosaminoglycan fixed combination and chewable composition comprising said fixed combination |
| IT201700124424A1 (it) * | 2017-10-31 | 2019-05-01 | Sofar Swiss Sa | Compressa da succhiare e/o sciogliere in bocca a base di acido ialuronico e condroitina solfato e loro sali |
| US11337992B2 (en) | 2016-10-10 | 2022-05-24 | Sofar Swiss Sa | Liquid composition for use in the treatment of gastroesophageal reflux |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5294412A (en) * | 1975-12-16 | 1977-08-09 | Nattermann A & Cie | Production of medicine based on oily phospholipid solution |
| JPS5663921A (en) * | 1979-10-15 | 1981-05-30 | Balazs Endre A | Appetite stimulating composition and its stimulating method |
-
1984
- 1984-08-13 JP JP16777584A patent/JPS6147418A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5294412A (en) * | 1975-12-16 | 1977-08-09 | Nattermann A & Cie | Production of medicine based on oily phospholipid solution |
| JPS5663921A (en) * | 1979-10-15 | 1981-05-30 | Balazs Endre A | Appetite stimulating composition and its stimulating method |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000001394A1 (en) * | 1998-07-06 | 2000-01-13 | Fidia Advanced Biopolymers S.R.L. | Biocompatible and biodegradable compositions containing hyaluronic acid and the derivatives thereof for the treatment of ulcers in the digestive apparatus |
| WO2000007577A3 (de) * | 1998-08-06 | 2000-10-26 | Wolfgang Stremmel | Phosphatidylcholin als arzneimittel mit schleimhautschützender wirkung |
| US6677319B1 (en) | 1998-08-06 | 2004-01-13 | Wolfgang Stremmel | Phosphatidylcholine as medication with protective effect large intestinal mucosa |
| US6566346B2 (en) | 2001-03-27 | 2003-05-20 | Q.P. Corporation | Oral skin improving agent, skin improving method, and food composition for improving skin |
| JP2009538287A (ja) * | 2006-05-26 | 2009-11-05 | アルテルゴン エス．エイ． | 低粘度グリコサミノグリカンで構成される組成及び該組成の間質性膀胱炎の治療での使用 |
| WO2010136872A2 (en) | 2009-05-25 | 2010-12-02 | Pharcoterm S.R.L. | Use of a glycosaminoglycan fixed combination and chewable composition comprising said fixed combination |
| WO2010136872A3 (en) * | 2009-05-25 | 2011-05-26 | Pharcoterm S.R.L. | Use of a glycosaminoglycan fixed combination and chewable composition comprising said fixed combination |
| US11337992B2 (en) | 2016-10-10 | 2022-05-24 | Sofar Swiss Sa | Liquid composition for use in the treatment of gastroesophageal reflux |
| US11690867B2 (en) | 2016-10-10 | 2023-07-04 | Sofar Swiss Sa | Liquid composition for use in the treatment of gastroesophageal reflux |
| IT201700124424A1 (it) * | 2017-10-31 | 2019-05-01 | Sofar Swiss Sa | Compressa da succhiare e/o sciogliere in bocca a base di acido ialuronico e condroitina solfato e loro sali |
| WO2019087105A1 (en) * | 2017-10-31 | 2019-05-09 | Sofar Swiss Sa | Suckable and/or melt-in-mouth tablet based on hyaluronic acid and chondroitin sulphate and salts thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0534341B2 (enExample) | 1993-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |