JPS6139318B2 - - Google Patents
Info
- Publication number
- JPS6139318B2 JPS6139318B2 JP51019810A JP1981076A JPS6139318B2 JP S6139318 B2 JPS6139318 B2 JP S6139318B2 JP 51019810 A JP51019810 A JP 51019810A JP 1981076 A JP1981076 A JP 1981076A JP S6139318 B2 JPS6139318 B2 JP S6139318B2
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- tri
- formula
- benzoyl
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752508312 DE2508312A1 (de) | 1975-02-24 | 1975-02-24 | Neues verfahren zur herstellung von nucleosiden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS51125382A JPS51125382A (en) | 1976-11-01 |
| JPS6139318B2 true JPS6139318B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1986-09-03 |
Family
ID=5939872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51019810A Granted JPS51125382A (en) | 1975-02-24 | 1976-02-24 | Production of nucleotide |
Country Status (12)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH029511U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1988-06-21 | 1990-01-22 | ||
| JPH07276137A (ja) * | 1994-03-31 | 1995-10-24 | Osaka Diamond Ind Co Ltd | 切削・研削用工具 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53108986A (en) * | 1977-03-02 | 1978-09-22 | Mitsui Toatsu Chem Inc | Preparation of nucleosides and nucleotides |
| DE2721466A1 (de) * | 1977-05-12 | 1978-11-16 | Robugen Gmbh | Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden |
| US4195176A (en) * | 1977-10-11 | 1980-03-25 | Warner-Lambert Company | Imidazole compounds, methods for their production and conversion of said compounds into (R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazol[4,5-d][1,3]diazepin-8-ol |
| DE2757365A1 (de) * | 1977-12-20 | 1979-06-21 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
| ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| CA2091732C (en) * | 1992-07-08 | 1998-07-21 | Anica Markovac | A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine |
| DE19513330A1 (de) * | 1995-04-03 | 1996-10-10 | Schering Ag | Neues Verfahren zur Herstellung von Nucleosiden |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CA2410579C (en) | 2000-05-26 | 2010-04-20 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses |
| US7662798B2 (en) | 2002-06-28 | 2010-02-16 | Idenix Pharmaceuticals, Inc. | 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| BR0316363A (pt) | 2002-11-15 | 2005-10-04 | Idenix Cayman Ltd | Nucleosìdeos 2'-ramificado e mutação de flaviviridae |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| US7038038B2 (en) * | 2003-03-17 | 2006-05-02 | Pharmion Corporation | Synthesis of 5-azacytidine |
| US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| EP1620451A4 (en) | 2003-04-28 | 2009-02-18 | Novartis Ag | TO THE MOST EXTENSIVE NUCLEOSIDE SYNTHESIS |
| MXPA06000162A (es) | 2003-06-30 | 2006-03-21 | Idenix Cayman Ltd | Sintesis de ?-l-2-desoxinucleosidos. |
| AT502635A1 (de) * | 2005-11-09 | 2007-05-15 | Saischek Und Partner Meg | Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung |
| EP1976382B1 (en) | 2005-12-23 | 2013-04-24 | IDENIX Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| EP2050757A1 (en) * | 2007-10-10 | 2009-04-22 | Cilag AG | Method of producing 2' -deoxy-5-azacytidine (Decitabine) |
| EP2048151A1 (en) | 2007-10-10 | 2009-04-15 | Cilag AG | Method for producing nucleosides by direct glycosylation of the nucleoside base |
| MX363023B (es) | 2008-05-15 | 2019-03-05 | Celgene Corp | Formulaciones orales de analogos de citidina y metodos para usar los mismos. |
| EP2321302B1 (en) * | 2008-08-01 | 2014-10-29 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| CN102171233A (zh) * | 2008-08-06 | 2011-08-31 | 西科尔公司 | 制备氮杂胞苷中间体的方法 |
| AR073003A1 (es) * | 2008-08-08 | 2010-10-06 | Scinopharm Taiwan Ltd | Proceso para preparar 5-azacitosina nucleosidos y sus derivados |
| EP2424845A4 (en) * | 2009-04-27 | 2014-03-05 | Reddys Lab Ltd Dr | PREPARATION OF DECITABIN |
| WO2012135405A1 (en) | 2011-03-31 | 2012-10-04 | Pharmion Llc | Systhesis of 5-azacytidine |
| CN108239128B (zh) * | 2016-12-23 | 2019-03-29 | 江苏奥赛康药业股份有限公司 | β-核苷类化合物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354160A (en) * | 1965-07-22 | 1967-11-21 | Hoffmann La Roche | Tri-lower alkyl-silyl-5-fluoropyrimidines |
| US3352849A (en) * | 1965-10-24 | 1967-11-14 | Merck & Co Inc | 6-aza-2'-deoxyuridines |
| CH541566A (de) * | 1969-04-11 | 1973-09-15 | Schering Ag | Verfahren zur Herstellung von Nucleosiden |
| DE2122991C2 (de) * | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
-
1975
- 1975-02-24 DE DE19752508312 patent/DE2508312A1/de active Granted
-
1976
- 1976-02-18 NL NL7601625A patent/NL7601625A/xx not_active Application Discontinuation
- 1976-02-23 CA CA246,368A patent/CA1065315A/en not_active Expired
- 1976-02-23 SE SE7602109A patent/SE7602109L/xx unknown
- 1976-02-23 US US05/660,675 patent/US4082911A/en not_active Expired - Lifetime
- 1976-02-23 GB GB767006A patent/GB1542442A/en not_active Expired
- 1976-02-23 LU LU74411A patent/LU74411A1/xx unknown
- 1976-02-24 CH CH227476A patent/CH626093A5/de not_active IP Right Cessation
- 1976-02-24 BE BE164585A patent/BE838879A/xx not_active IP Right Cessation
- 1976-02-24 FR FR7605030A patent/FR2301536A1/fr active Granted
- 1976-02-24 JP JP51019810A patent/JPS51125382A/ja active Granted
- 1976-02-24 DK DK77176A patent/DK138900C/da active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH029511U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1988-06-21 | 1990-01-22 | ||
| JPH07276137A (ja) * | 1994-03-31 | 1995-10-24 | Osaka Diamond Ind Co Ltd | 切削・研削用工具 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2301536B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-07-27 |
| GB1542442A (en) | 1979-03-21 |
| NL7601625A (nl) | 1976-08-26 |
| DE2508312C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-10-29 |
| LU74411A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-08-13 |
| SE7602109L (sv) | 1976-08-25 |
| DE2508312A1 (de) | 1976-09-02 |
| CA1065315A (en) | 1979-10-30 |
| DK138900C (da) | 1979-04-30 |
| US4082911A (en) | 1978-04-04 |
| CH626093A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-10-30 |
| BE838879A (fr) | 1976-08-24 |
| JPS51125382A (en) | 1976-11-01 |
| DK138900B (da) | 1978-11-13 |
| DK77176A (da) | 1976-08-25 |
| FR2301536A1 (fr) | 1976-09-17 |
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