JPS61286330A - 経口徐放性製剤 - Google Patents
経口徐放性製剤Info
- Publication number
- JPS61286330A JPS61286330A JP12513985A JP12513985A JPS61286330A JP S61286330 A JPS61286330 A JP S61286330A JP 12513985 A JP12513985 A JP 12513985A JP 12513985 A JP12513985 A JP 12513985A JP S61286330 A JPS61286330 A JP S61286330A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- polyacrylic acid
- lower alkyl
- alkyl ether
- cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 58
- 229940079593 drug Drugs 0.000 claims abstract description 56
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 31
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 30
- 239000008187 granular material Substances 0.000 claims abstract description 26
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- 229920002678 cellulose Polymers 0.000 claims abstract description 20
- 239000001913 cellulose Substances 0.000 claims abstract description 20
- 150000005215 alkyl ethers Chemical class 0.000 claims abstract description 16
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 13
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 13
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 13
- 239000002245 particle Substances 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 25
- 235000010980 cellulose Nutrition 0.000 claims description 18
- 239000003405 delayed action preparation Substances 0.000 claims description 17
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 2
- 210000002784 stomach Anatomy 0.000 abstract description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract description 3
- 229920001577 copolymer Polymers 0.000 abstract description 3
- 210000000936 intestine Anatomy 0.000 abstract description 3
- 229920001519 homopolymer Polymers 0.000 abstract 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 14
- 238000013268 sustained release Methods 0.000 description 14
- 239000012730 sustained-release form Substances 0.000 description 14
- 238000009472 formulation Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- -1 tri-hydroxypropyl methyl Chemical group 0.000 description 10
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 7
- 229960002477 riboflavin Drugs 0.000 description 7
- 239000002151 riboflavin Substances 0.000 description 7
- 235000019192 riboflavin Nutrition 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 5
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- 239000000314 lubricant Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
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- 239000011248 coating agent Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
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- 239000003826 tablet Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000005011 alkyl ether group Chemical group 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- PGZIKUPSQINGKT-UHFFFAOYSA-N dialuminum;dioxido(oxo)silane Chemical compound [Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O PGZIKUPSQINGKT-UHFFFAOYSA-N 0.000 description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229960001597 nifedipine Drugs 0.000 description 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- BJYLYJCXYAMOFT-RRXOBRNQSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCC(O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RRXOBRNQSA-N 0.000 description 1
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 1
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 1
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- FEDJGPQLLNQAIY-UHFFFAOYSA-N 2-[(6-oxo-1h-pyridazin-3-yl)oxy]acetic acid Chemical compound OC(=O)COC=1C=CC(=O)NN=1 FEDJGPQLLNQAIY-UHFFFAOYSA-N 0.000 description 1
- GGCILSXUAHLDMF-CQSZACIVSA-N 2-[[2-[(3r)-3-aminopiperidin-1-yl]-5-bromo-6-oxopyrimidin-1-yl]methyl]benzonitrile Chemical compound C1[C@H](N)CCCN1C1=NC=C(Br)C(=O)N1CC1=CC=CC=C1C#N GGCILSXUAHLDMF-CQSZACIVSA-N 0.000 description 1
- CRFFPDBJLGAGQL-UHFFFAOYSA-N 2-azaniumyl-3-[4-(trifluoromethyl)phenyl]propanoate Chemical compound OC(=O)C(N)CC1=CC=C(C(F)(F)F)C=C1 CRFFPDBJLGAGQL-UHFFFAOYSA-N 0.000 description 1
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- PJJGZPJJTHBVMX-UHFFFAOYSA-N 5,7-Dihydroxyisoflavone Chemical compound C=1C(O)=CC(O)=C(C2=O)C=1OC=C2C1=CC=CC=C1 PJJGZPJJTHBVMX-UHFFFAOYSA-N 0.000 description 1
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- 239000000600 sorbitol Substances 0.000 description 1
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- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12513985A JPS61286330A (ja) | 1985-06-11 | 1985-06-11 | 経口徐放性製剤 |
| EP86304400A EP0205336B1 (en) | 1985-06-11 | 1986-06-10 | Oral sustained release pharmaceutical preparation |
| DE8686304400T DE3681348D1 (de) | 1985-06-11 | 1986-06-10 | Oral-arzneizubereitung mit retardwirkung. |
| US06/872,996 US4777033A (en) | 1985-06-11 | 1986-06-11 | Oral sustained release pharmaceutical preparation |
| MYPI87001165A MY102459A (en) | 1985-06-11 | 1987-07-29 | Oral sustained release pharmaceutical preparation. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12513985A JPS61286330A (ja) | 1985-06-11 | 1985-06-11 | 経口徐放性製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61286330A true JPS61286330A (ja) | 1986-12-16 |
| JPH057367B2 JPH057367B2 (en, 2012) | 1993-01-28 |
Family
ID=14902826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12513985A Granted JPS61286330A (ja) | 1985-06-11 | 1985-06-11 | 経口徐放性製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61286330A (en, 2012) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6277335A (ja) * | 1985-09-30 | 1987-04-09 | Fujisawa Pharmaceut Co Ltd | ゲル層形成型徐放性製剤 |
| JPS63227519A (ja) * | 1987-02-27 | 1988-09-21 | イーライ・リリー・アンド・カンパニー | 徐放性マトリックス製剤 |
| US5174998A (en) * | 1988-11-30 | 1992-12-29 | Nisshin Flour Milling Co., Ltd. | Sustained release compositions using as matrix hemicellulose extracted from wheat bran |
| JP2003531849A (ja) * | 2000-04-28 | 2003-10-28 | アダムス ラボラトリーズ，インコーポレーテッド | グアイフェネシン徐放製剤および錠剤 |
| JP2013504615A (ja) * | 2009-09-23 | 2013-02-07 | コリア ユナイテッド ファーム，インク | 溶出率向上と副作用発現が最小化されたシルロスタゾール徐放錠 |
| JP2013224273A (ja) * | 2012-04-20 | 2013-10-31 | Nisshin Pharma Inc | 腸内環境改善有核錠製剤及びハードカプセル製剤 |
| JP2015042669A (ja) * | 2014-10-30 | 2015-03-05 | コリア ユナイテッド ファーム，インク | 溶出率向上と副作用発現が最小化されたシルロスタゾール徐放錠 |
| WO2024058093A1 (ja) * | 2022-09-16 | 2024-03-21 | 東和薬品株式会社 | 時限放出型顆粒およびその用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60185728A (ja) * | 1983-12-01 | 1985-09-21 | ハンス ロウエイ | 徐放性医薬担体 |
| JPS61148115A (ja) * | 1984-12-21 | 1986-07-05 | Tooa Eiyoo Kk | 難溶性薬物の徐放性製剤及びその製造法 |
-
1985
- 1985-06-11 JP JP12513985A patent/JPS61286330A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60185728A (ja) * | 1983-12-01 | 1985-09-21 | ハンス ロウエイ | 徐放性医薬担体 |
| JPS61148115A (ja) * | 1984-12-21 | 1986-07-05 | Tooa Eiyoo Kk | 難溶性薬物の徐放性製剤及びその製造法 |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6277335A (ja) * | 1985-09-30 | 1987-04-09 | Fujisawa Pharmaceut Co Ltd | ゲル層形成型徐放性製剤 |
| JPS63227519A (ja) * | 1987-02-27 | 1988-09-21 | イーライ・リリー・アンド・カンパニー | 徐放性マトリックス製剤 |
| US5174998A (en) * | 1988-11-30 | 1992-12-29 | Nisshin Flour Milling Co., Ltd. | Sustained release compositions using as matrix hemicellulose extracted from wheat bran |
| JP2003531849A (ja) * | 2000-04-28 | 2003-10-28 | アダムス ラボラトリーズ，インコーポレーテッド | グアイフェネシン徐放製剤および錠剤 |
| JP2013504615A (ja) * | 2009-09-23 | 2013-02-07 | コリア ユナイテッド ファーム，インク | 溶出率向上と副作用発現が最小化されたシルロスタゾール徐放錠 |
| JP2013224273A (ja) * | 2012-04-20 | 2013-10-31 | Nisshin Pharma Inc | 腸内環境改善有核錠製剤及びハードカプセル製剤 |
| JP2015042669A (ja) * | 2014-10-30 | 2015-03-05 | コリア ユナイテッド ファーム，インク | 溶出率向上と副作用発現が最小化されたシルロスタゾール徐放錠 |
| WO2024058093A1 (ja) * | 2022-09-16 | 2024-03-21 | 東和薬品株式会社 | 時限放出型顆粒およびその用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH057367B2 (en, 2012) | 1993-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |