JPS611615A - 水虫外用薬 - Google Patents
水虫外用薬Info
- Publication number
- JPS611615A JPS611615A JP59121586A JP12158684A JPS611615A JP S611615 A JPS611615 A JP S611615A JP 59121586 A JP59121586 A JP 59121586A JP 12158684 A JP12158684 A JP 12158684A JP S611615 A JPS611615 A JP S611615A
- Authority
- JP
- Japan
- Prior art keywords
- urea
- athlete
- drug
- foot
- trichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 51
- 201000004647 tinea pedis Diseases 0.000 title claims abstract description 37
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 title claims abstract description 36
- 229940079593 drug Drugs 0.000 title abstract description 36
- 239000004202 carbamide Substances 0.000 claims abstract description 33
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 32
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 20
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000008311 hydrophilic ointment Substances 0.000 claims description 3
- 229940121375 antifungal agent Drugs 0.000 abstract description 12
- 102000011782 Keratins Human genes 0.000 abstract description 7
- 108010076876 Keratins Proteins 0.000 abstract description 7
- 239000003429 antifungal agent Substances 0.000 abstract description 3
- 230000002538 fungal effect Effects 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 230000000857 drug effect Effects 0.000 abstract description 2
- 230000001716 anti-fugal effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000000246 remedial effect Effects 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 29
- 230000000843 anti-fungal effect Effects 0.000 description 17
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 12
- 241000233866 Fungi Species 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 210000000434 stratum corneum Anatomy 0.000 description 8
- 239000003381 stabilizer Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 229910021529 ammonia Inorganic materials 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 208000017520 skin disease Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- OWYWGLHRNBIFJP-UHFFFAOYSA-N Ipazine Chemical compound CCN(CC)C1=NC(Cl)=NC(NC(C)C)=N1 OWYWGLHRNBIFJP-UHFFFAOYSA-N 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 206010024380 Leukoderma Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 206010059516 Skin toxicity Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 238000004362 fungal culture Methods 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- -1 hydroxy diphenyl ether Chemical compound 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59121586A JPS611615A (ja) | 1984-06-12 | 1984-06-12 | 水虫外用薬 |
| CH2387/85A CH664084A5 (it) | 1984-06-12 | 1985-06-05 | Medicamento ad uso esterno per il piede d'atleta. |
| DE19853520325 DE3520325A1 (de) | 1984-06-12 | 1985-06-07 | Aeusserlich anwendbares medikament gegen fusspilz |
| GB08514792A GB2160099B (en) | 1984-06-12 | 1985-06-11 | Treatment of athlete's foot |
| FR8509273A FR2565486B1 (fr) | 1984-06-12 | 1985-06-11 | Medicament a application externe pour dermatophytose ou mycose dite du sportif |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59121586A JPS611615A (ja) | 1984-06-12 | 1984-06-12 | 水虫外用薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS611615A true JPS611615A (ja) | 1986-01-07 |
| JPS6344724B2 JPS6344724B2 (en)) | 1988-09-06 |
Family
ID=14814907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59121586A Granted JPS611615A (ja) | 1984-06-12 | 1984-06-12 | 水虫外用薬 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS611615A (en)) |
| CH (1) | CH664084A5 (en)) |
| DE (1) | DE3520325A1 (en)) |
| FR (1) | FR2565486B1 (en)) |
| GB (1) | GB2160099B (en)) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6388120A (ja) * | 1986-09-19 | 1988-04-19 | ファイザー・インコーポレーテッド | 医薬含有皮膚用製剤 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69921058T2 (de) * | 1998-10-06 | 2006-02-02 | I-Dent International Corp. | Verwendung von Triclosan zur Behandlung und Prävention von Mukositis |
| EP2007390A4 (en) * | 2006-04-04 | 2009-11-25 | Avner Shemer | TREATMENT KIT FOR SKIN INFECTION |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3605163A (en) * | 1969-01-10 | 1971-09-20 | Chemway Corp | Bacteriostatic toothbrushes |
| US3629477A (en) * | 1966-08-08 | 1971-12-21 | Geigy Chem Corp | Halogenated diphenyether-containing compositions and control of pests therewith |
| US3723326A (en) * | 1970-09-11 | 1973-03-27 | Lever Brothers Ltd | Detergent compositions |
| US3725547A (en) * | 1970-10-08 | 1973-04-03 | Procter & Gamble | Synergistic antibacterial combination |
| DE2254663A1 (de) * | 1971-11-08 | 1973-05-10 | Armour Pharma | Antimikrobische aluminiumhalogenidverbindungen enthaltende mischungen |
| US3794587A (en) * | 1972-03-24 | 1974-02-26 | Armour Dial Inc | Synergistic antiseptic compositions |
| JPS5210424A (en) * | 1975-07-09 | 1977-01-26 | Taisho Pharmaceut Co Ltd | A method for preparing a remedy against cutaneous fungi |
| JPS5287235A (en) * | 1976-01-06 | 1977-07-20 | Taisho Pharmaceut Co Ltd | Remedies for dermatomycosis |
| US4294855A (en) * | 1975-11-26 | 1981-10-13 | Desoto, Inc. | Emollient and/or dyed prilled urea bath bead composition |
| JPS58150509A (ja) * | 1982-03-03 | 1983-09-07 | Taisho Pharmaceut Co Ltd | 白癬症治療剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH406127A (de) * | 1963-02-22 | 1966-08-15 | Geigy Ag J R | Verfahren zum antimikrobiellen Ausrüsten von Textilien |
| FR2505325A1 (fr) * | 1981-05-08 | 1982-11-12 | Reisacher Fils Laboratoires A | Procede et solution pour eviter les odeurs de transpiration des pieds |
-
1984
- 1984-06-12 JP JP59121586A patent/JPS611615A/ja active Granted
-
1985
- 1985-06-05 CH CH2387/85A patent/CH664084A5/it not_active IP Right Cessation
- 1985-06-07 DE DE19853520325 patent/DE3520325A1/de active Granted
- 1985-06-11 GB GB08514792A patent/GB2160099B/en not_active Expired
- 1985-06-11 FR FR8509273A patent/FR2565486B1/fr not_active Expired
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3629477A (en) * | 1966-08-08 | 1971-12-21 | Geigy Chem Corp | Halogenated diphenyether-containing compositions and control of pests therewith |
| US3605163A (en) * | 1969-01-10 | 1971-09-20 | Chemway Corp | Bacteriostatic toothbrushes |
| US3723326A (en) * | 1970-09-11 | 1973-03-27 | Lever Brothers Ltd | Detergent compositions |
| US3725547A (en) * | 1970-10-08 | 1973-04-03 | Procter & Gamble | Synergistic antibacterial combination |
| DE2254663A1 (de) * | 1971-11-08 | 1973-05-10 | Armour Pharma | Antimikrobische aluminiumhalogenidverbindungen enthaltende mischungen |
| US3794587A (en) * | 1972-03-24 | 1974-02-26 | Armour Dial Inc | Synergistic antiseptic compositions |
| JPS5210424A (en) * | 1975-07-09 | 1977-01-26 | Taisho Pharmaceut Co Ltd | A method for preparing a remedy against cutaneous fungi |
| US4294855A (en) * | 1975-11-26 | 1981-10-13 | Desoto, Inc. | Emollient and/or dyed prilled urea bath bead composition |
| JPS5287235A (en) * | 1976-01-06 | 1977-07-20 | Taisho Pharmaceut Co Ltd | Remedies for dermatomycosis |
| JPS58150509A (ja) * | 1982-03-03 | 1983-09-07 | Taisho Pharmaceut Co Ltd | 白癬症治療剤 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6388120A (ja) * | 1986-09-19 | 1988-04-19 | ファイザー・インコーポレーテッド | 医薬含有皮膚用製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2160099B (en) | 1988-01-20 |
| DE3520325C2 (en)) | 1988-08-04 |
| FR2565486B1 (fr) | 1988-12-02 |
| FR2565486A1 (fr) | 1985-12-13 |
| GB2160099A (en) | 1985-12-18 |
| JPS6344724B2 (en)) | 1988-09-06 |
| CH664084A5 (it) | 1988-02-15 |
| GB8514792D0 (en) | 1985-07-10 |
| DE3520325A1 (de) | 1985-12-12 |
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