JPS604188B2 - ２−〔４−（２−フロイル）ピペラジン−１−イル〕−４−アミノ−６，７−ジメトキシキナゾリン塩酸塩の新規な結晶形 - Google Patents

２−〔４−（２−フロイル）ピペラジン−１−イル〕−４−アミノ−６，７−ジメトキシキナゾリン塩酸塩の新規な結晶形

Info

Publication number
JPS604188B2
JPS604188B2 JP52021433A JP2143377A JPS604188B2 JP S604188 B2 JPS604188 B2 JP S604188B2 JP 52021433 A JP52021433 A JP 52021433A JP 2143377 A JP2143377 A JP 2143377A JP S604188 B2 JPS604188 B2 JP S604188B2
Authority
JP
Japan
Prior art keywords
prazosin hydrochloride
water
hydrochloride
furoyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52021433A
Other languages
English (en)
Japanese (ja)
Other versions
JPS52105206A (en
Inventor
ア−ネスト・ジヨン・ビアンコ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Priority to US05/826,560 priority Critical patent/US4162661A/en
Publication of JPS52105206A publication Critical patent/JPS52105206A/ja
Publication of JPS604188B2 publication Critical patent/JPS604188B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
JP52021433A 1976-03-01 1977-02-28 ２−〔４−（２−フロイル）ピペラジン−１−イル〕−４−アミノ−６，７−ジメトキシキナゾリン塩酸塩の新規な結晶形 Expired JPS604188B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US05/826,560 US4162661A (en) 1977-02-25 1977-08-22 Internal combustion engine with combustion chambers which create a squish and swirl of an air-fuel mixture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/662,937 US4092315A (en) 1976-03-01 1976-03-01 Novel crystalline forms of prazosin hydrochloride
US662937 2003-09-15

Publications (2)

Publication Number Publication Date
JPS52105206A JPS52105206A (en) 1977-09-03
JPS604188B2 true JPS604188B2 (ja) 1985-02-01

Family

ID=24659839

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52021433A Expired JPS604188B2 (ja) 1976-03-01 1977-02-28 ２−〔４−（２−フロイル）ピペラジン−１−イル〕−４−アミノ−６，７−ジメトキシキナゾリン塩酸塩の新規な結晶形

Country Status (32)

Country Link
US (1) US4092315A (enFirst)
JP (1) JPS604188B2 (enFirst)
AR (1) AR210937A1 (enFirst)
AU (1) AU506937B2 (enFirst)
BE (1) BE851878A (enFirst)
BG (1) BG29724A3 (enFirst)
CA (1) CA1068269A (enFirst)
CH (1) CH618436A5 (enFirst)
CS (1) CS191332B2 (enFirst)
DD (1) DD129652A5 (enFirst)
DE (1) DE2708192C3 (enFirst)
DK (1) DK145858C (enFirst)
ES (1) ES8707447A1 (enFirst)
FI (1) FI62082C (enFirst)
FR (1) FR2372828A1 (enFirst)
GB (1) GB1538713A (enFirst)
HK (1) HK30881A (enFirst)
HU (1) HU173641B (enFirst)
IE (1) IE44522B1 (enFirst)
IL (1) IL51481A (enFirst)
LU (1) LU76868A1 (enFirst)
MY (1) MY8100271A (enFirst)
NL (1) NL169591C (enFirst)
NO (1) NO146499C (enFirst)
NZ (1) NZ183450A (enFirst)
PL (1) PL105559B1 (enFirst)
PT (1) PT66227B (enFirst)
RO (1) RO73095A (enFirst)
SE (1) SE423234B (enFirst)
SU (1) SU644387A3 (enFirst)
YU (1) YU41294B (enFirst)
ZA (1) ZA77918B (enFirst)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX5483E (es) * 1977-08-04 1983-08-23 Abbott Lab Procedimiento para la preparacion del dihidrato clorhidrato de 1-(4-amino-6,7-dimetoxi-2-quinazolinil)-4-(2-tetrahidrofuroil)piperazina
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4197301A (en) * 1978-10-16 1980-04-08 Allergan Pharmaceuticals, Inc. Topical ophthalmic use of Prazosin
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
US4440769A (en) * 1983-02-11 1984-04-03 Abbott Laboratories 2-(4-Phenylalkanoylpiperazin-1-yl) quinazoline compounds, pharmaceutical compositions and method of producing α1 antagonistic activity
FI79107C (fi) * 1984-06-25 1989-11-10 Orion Yhtymae Oy Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.
US5322943A (en) * 1985-09-12 1994-06-21 The Upjohn Company Piperazine compounds which are substituted
US4601897A (en) * 1985-11-06 1986-07-22 Pfizer Inc. Prazosin-pirbuterol combination for bronchodilation
ATE72244T1 (de) * 1986-03-21 1992-02-15 Heumann Pharma Gmbh & Co Kristalline, wasserfreie sigma -form von 2-(4-(2furoyl-(2-piperazin)-1-yl>-4-amino-6,7- dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung.
US5110927A (en) * 1987-12-31 1992-05-05 The United States Of America As Represented By The Department Of Health And Human Services Prazosin analog with increased selectivity and duration of action
JP2652272B2 (ja) * 1990-12-31 1997-09-10 住化ファインケム株式会社 １−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
US5952003A (en) * 1996-08-01 1999-09-14 Novartis Corporation Terazosin capsules
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
EP0849266B8 (de) * 1996-12-20 2007-10-03 Heumann PCS GmbH Neue polymorphe Form von Doxazosinmesylat (Form III)
CA2993152C (en) 2014-07-21 2022-12-13 Keir Manufacturing, Inc. Aerodynamic flyer bow

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines

Also Published As

Publication number Publication date
CH618436A5 (enFirst) 1980-07-31
SE423234B (sv) 1982-04-26
FR2372828B1 (enFirst) 1980-02-01
DE2708192C3 (de) 1980-05-08
CS191332B2 (en) 1979-06-29
NL169591B (nl) 1982-03-01
PT66227B (en) 1978-07-14
NO770674L (no) 1977-09-02
AU2244377A (en) 1978-11-23
ES8707447A1 (es) 1987-08-16
YU41294B (en) 1987-02-28
DK145858B (da) 1983-03-21
MY8100271A (en) 1981-12-31
HU173641B (en) 1979-07-28
DK86877A (da) 1977-09-02
IL51481A (en) 1980-09-16
HK30881A (en) 1981-07-10
BE851878A (fr) 1977-08-29
NO146499B (no) 1982-07-05
SE7701624L (sv) 1977-09-02
FI770634A7 (enFirst) 1977-09-02
JPS52105206A (en) 1977-09-03
IE44522B1 (en) 1981-12-30
NZ183450A (en) 1979-03-16
FI62082B (fi) 1982-07-30
CA1068269A (en) 1979-12-18
BG29724A3 (bg) 1981-01-15
ZA77918B (en) 1977-12-28
ES545368A0 (es) 1978-06-01
YU49977A (en) 1983-12-31
AR210937A1 (es) 1977-09-30
IE44522L (en) 1977-09-01
SU644387A3 (ru) 1979-01-25
FI62082C (fi) 1982-11-10
DE2708192A1 (de) 1977-09-08
NO146499C (no) 1982-10-13
GB1538713A (en) 1979-01-24
AU506937B2 (en) 1980-01-31
FR2372828A1 (fr) 1978-06-30
LU76868A1 (enFirst) 1977-09-21
PT66227A (en) 1977-03-01
DD129652A5 (de) 1978-02-01
DK145858C (da) 1983-09-12
RO73095A (ro) 1981-06-26
PL196354A1 (pl) 1978-02-27
IL51481A0 (en) 1977-04-29
US4092315A (en) 1978-05-30
PL105559B1 (pl) 1979-10-31
DE2708192B2 (de) 1979-08-02
NL169591C (nl) 1982-08-02
NL7702123A (nl) 1977-09-05

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