JPS6033109B2 - 尿素誘導体の合成法 - Google Patents

尿素誘導体の合成法

Info

Publication number
JPS6033109B2
JPS6033109B2 JP52049629A JP4962977A JPS6033109B2 JP S6033109 B2 JPS6033109 B2 JP S6033109B2 JP 52049629 A JP52049629 A JP 52049629A JP 4962977 A JP4962977 A JP 4962977A JP S6033109 B2 JPS6033109 B2 JP S6033109B2
Authority
JP
Japan
Prior art keywords
urea
chloride
reaction
butyl
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52049629A
Other languages
English (en)
Japanese (ja)
Other versions
JPS53135972A (en
Inventor
徳夫 牧角
隆司 笹谷
旭 村林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP52049629A priority Critical patent/JPS6033109B2/ja
Priority to CA300,467A priority patent/CA1093081A/en
Priority to GB13400/78A priority patent/GB1572976A/en
Priority to IL54468A priority patent/IL54468A0/xx
Priority to US05/895,105 priority patent/US4183856A/en
Priority to IE707/78A priority patent/IE46769B1/en
Priority to ES468897A priority patent/ES468897A1/es
Priority to SE7804596A priority patent/SE442867B/sv
Priority to DK180378A priority patent/DK144011C/da
Priority to AU35468/78A priority patent/AU513688B2/en
Priority to BR7802618A priority patent/BR7802618A/pt
Priority to NLAANVRAGE7804550,A priority patent/NL183513C/xx
Priority to HU78SI1624A priority patent/HU176881B/hu
Priority to DD78205055A priority patent/DD135905A5/xx
Priority to IT67959/78A priority patent/IT1111465B/it
Priority to FR7812529A priority patent/FR2388802A1/fr
Priority to PL1978206450A priority patent/PL110681B1/pl
Priority to YU1037/78A priority patent/YU40334B/xx
Priority to BG039586A priority patent/BG33278A3/xx
Priority to DE19782818947 priority patent/DE2818947A1/de
Priority to CS782773A priority patent/CS198297B2/cs
Priority to SU782608147A priority patent/SU1091853A3/ru
Priority to BE187289A priority patent/BE866581A/xx
Priority to CH470378A priority patent/CH633542A5/de
Publication of JPS53135972A publication Critical patent/JPS53135972A/ja
Priority to AR284939A priority patent/AR225666A1/es
Publication of JPS6033109B2 publication Critical patent/JPS6033109B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP52049629A 1977-04-28 1977-04-28 尿素誘導体の合成法 Expired JPS6033109B2 (ja)

Priority Applications (25)

Application Number Priority Date Filing Date Title
JP52049629A JPS6033109B2 (ja) 1977-04-28 1977-04-28 尿素誘導体の合成法
CA300,467A CA1093081A (en) 1977-04-28 1978-04-05 Process for the production of aryl ureas
GB13400/78A GB1572976A (en) 1977-04-28 1978-04-05 Process for the production of uea derivatives
IL54468A IL54468A0 (en) 1977-04-28 1978-04-10 Process for the preparation of urea derivatives, urea derivatives obtained thereby and herbicide formulations comprising or containing said derivatives
US05/895,105 US4183856A (en) 1977-04-28 1978-04-10 Process for the production of urea derivatives
IE707/78A IE46769B1 (en) 1977-04-28 1978-04-11 Process for the production of urea derivatives
ES468897A ES468897A1 (es) 1977-04-28 1978-04-18 Procedimiento para la obtencion de derivados de urea.
SE7804596A SE442867B (sv) 1977-04-28 1978-04-21 Forfarande for framstellning av karbamidderivat
DK180378A DK144011C (da) 1977-04-28 1978-04-25 Fremgangsmaade til fremstilling af heteroaromatiske urinstofderivater
AU35468/78A AU513688B2 (en) 1977-04-28 1978-04-26 1, l-disubstituted-3-heterocyclo urea derivatives
DD78205055A DD135905A5 (de) 1977-04-28 1978-04-27 Verfahren zur herstellung von harnstoffderivaten
NLAANVRAGE7804550,A NL183513C (nl) 1977-04-28 1978-04-27 Werkwijze voor het bereiden van ureumderivaten.
HU78SI1624A HU176881B (en) 1977-04-28 1978-04-27 Process for producing derivatives of urea
BR7802618A BR7802618A (pt) 1977-04-28 1978-04-27 Processo para a producao de derivados de ureia
IT67959/78A IT1111465B (it) 1977-04-28 1978-04-27 Procedimento per la produzione di derivati dell urea particolarmente utili come erbicidi
FR7812529A FR2388802A1 (fr) 1977-04-28 1978-04-27 Procede de production de derives d'uree et nouveaux produits ainsi obtenus
DE19782818947 DE2818947A1 (de) 1977-04-28 1978-04-28 Verfahren zur herstellung von harnstoffderivaten
YU1037/78A YU40334B (en) 1977-04-28 1978-04-28 Process for obtaining isoxazolyl-carbamide derivatives
BG039586A BG33278A3 (en) 1977-04-28 1978-04-28 Method for making of carbamide derivatives
PL1978206450A PL110681B1 (en) 1977-04-28 1978-04-28 Method of producing derivatives of urea
CS782773A CS198297B2 (en) 1977-04-28 1978-04-28 Method of producing derivatives of urea
SU782608147A SU1091853A3 (ru) 1977-04-28 1978-04-28 Способ получени производных мочевины
BE187289A BE866581A (fr) 1977-04-28 1978-04-28 Procede de production de derives de l'uree
CH470378A CH633542A5 (de) 1977-04-28 1978-04-28 Verfahren zur herstellung von harnstoffderivaten.
AR284939A AR225666A1 (es) 1977-04-28 1981-04-10 Procedimiento para la produccion de derivados para la produccion de derivados de 1-alquil-1-alquenil,alcoxi o alquil-3-5-alquil,fenil o halo-3-isoxazolilourea

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52049629A JPS6033109B2 (ja) 1977-04-28 1977-04-28 尿素誘導体の合成法

Publications (2)

Publication Number Publication Date
JPS53135972A JPS53135972A (en) 1978-11-28
JPS6033109B2 true JPS6033109B2 (ja) 1985-08-01

Family

ID=12836505

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52049629A Expired JPS6033109B2 (ja) 1977-04-28 1977-04-28 尿素誘導体の合成法

Country Status (25)

Country Link
US (1) US4183856A (https=)
JP (1) JPS6033109B2 (https=)
AR (1) AR225666A1 (https=)
AU (1) AU513688B2 (https=)
BE (1) BE866581A (https=)
BG (1) BG33278A3 (https=)
BR (1) BR7802618A (https=)
CA (1) CA1093081A (https=)
CH (1) CH633542A5 (https=)
CS (1) CS198297B2 (https=)
DD (1) DD135905A5 (https=)
DE (1) DE2818947A1 (https=)
DK (1) DK144011C (https=)
ES (1) ES468897A1 (https=)
FR (1) FR2388802A1 (https=)
GB (1) GB1572976A (https=)
HU (1) HU176881B (https=)
IE (1) IE46769B1 (https=)
IL (1) IL54468A0 (https=)
IT (1) IT1111465B (https=)
NL (1) NL183513C (https=)
PL (1) PL110681B1 (https=)
SE (1) SE442867B (https=)
SU (1) SU1091853A3 (https=)
YU (1) YU40334B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422461D0 (en) * 1984-09-05 1984-10-10 Wyeth John & Brother Ltd Pyridine derivatives
US4808722A (en) * 1985-10-31 1989-02-28 Fmc Corporation Pyridinylurea N-oxide compounds and agricultural uses
DK0427963T3 (da) * 1989-11-10 1994-05-02 Agrolinz Agrarchemikalien Fremgangsmåde til fremstilling af rene, asymmetrisk disubstituerede urinstoffer
DE3940261A1 (de) * 1989-12-06 1991-06-13 Agrolinz Agrarchemikalien Muen Verfahren zur herstellung reiner, unsymmetrisch disubstituierter harnstoffe
WO2003055482A1 (en) * 2001-12-21 2003-07-10 Novo Nordisk A/S Amide derivatives as gk activators
BR0312023A (pt) * 2002-06-27 2005-03-22 Novo Nordisk As Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica
JP4834840B2 (ja) * 2004-01-06 2011-12-14 ノヴォ ノルディスク アー／エス ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用
US7582769B2 (en) * 2005-07-08 2009-09-01 Novo Nordisk A/S Dicycloalkyl urea glucokinase activators
ES2382815T3 (es) * 2005-07-08 2012-06-13 Novo Nordisk A/S Dicicloalquilcarbamoil ureas como activadores de glucoquinasa
US7884210B2 (en) * 2005-07-14 2011-02-08 Novo Nordisk A/S Ureido-thiazole glucokinase activators
WO2008084043A1 (en) * 2007-01-09 2008-07-17 Novo Nordisk A/S Urea glucokinase activators
WO2008084044A1 (en) 2007-01-11 2008-07-17 Novo Nordisk A/S Urea glucokinase activators
CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2755285A (en) * 1956-07-17 I-xsubstituted
US2756135A (en) * 1955-07-13 1956-07-24 Du Pont 1-methyl-3-(2-benzothiazolyl)-ureas and their use as herbicides
DE1209801B (de) * 1963-05-11 1966-01-27 Bayer Ag Unkrautbekaempfung in Rueben
US3293257A (en) * 1964-09-14 1966-12-20 United States Borax Chem Pyridyl urea compounds
FR1533184A (fr) * 1965-04-06 1968-07-19 Pechiney Saint Gobain Dérivés du thiazole
DE1620448C3 (de) * 1965-05-08 1974-08-29 Schering Ag, 1000 Berlin Und 4619 Bergkamen Harnstoff- bzw. Thioharnstoffderivate des 3-Methylisothiazols
US3622593A (en) * 1967-08-09 1971-11-23 Fmc Corp 1,1-dimethyl-3-(isothiazol-5-yl)urea
US3547940A (en) * 1967-10-31 1970-12-15 Du Pont Substituted ureido isoxazoles
GB1266769A (https=) * 1969-08-15 1972-03-15
JPS5031039A (https=) * 1973-07-27 1975-03-27
US4062861A (en) * 1973-07-27 1977-12-13 Shionogi & Co., Ltd. 3-Isoxazolylurea derivatives
US4013706A (en) * 1973-11-14 1977-03-22 Sucreries Du Soissonnais Et Compagnie Sucriere Derivatives of substituted urea, acyl ureas, and sulphonyl ureas, and a process for producing the same
US4046770A (en) * 1974-08-30 1977-09-06 Eli Lilly And Company N-(6-acyloxybenzothiazol-2-yl)-N'-phenyl (or substituted phenyl)ureas
JPS5810361B2 (ja) * 1974-10-04 1983-02-25 塩野義製薬株式会社 ３−アルチルイソオキサゾ−ル系除草剤

Also Published As

Publication number Publication date
FR2388802A1 (fr) 1978-11-24
IE780707L (en) 1978-10-28
IT1111465B (it) 1986-01-13
YU103778A (en) 1982-10-31
CA1093081A (en) 1981-01-06
HU176881B (en) 1981-05-28
DK144011B (da) 1981-11-16
BG33278A3 (en) 1983-01-14
PL206450A1 (pl) 1979-03-26
NL183513C (nl) 1988-11-16
SE442867B (sv) 1986-02-03
ES468897A1 (es) 1978-11-16
DK144011C (da) 1982-04-26
PL110681B1 (en) 1980-07-31
NL7804550A (nl) 1978-10-31
YU40334B (en) 1985-12-31
DK180378A (da) 1978-10-29
JPS53135972A (en) 1978-11-28
IL54468A0 (en) 1978-07-31
CH633542A5 (de) 1982-12-15
NL183513B (nl) 1988-06-16
FR2388802B1 (https=) 1980-04-04
AU3546878A (en) 1979-11-01
BR7802618A (pt) 1979-04-03
SE7804596L (sv) 1978-10-29
DE2818947C2 (https=) 1991-08-22
AU513688B2 (en) 1980-12-18
SU1091853A3 (ru) 1984-05-07
AR225666A1 (es) 1982-04-15
BE866581A (fr) 1978-08-14
DE2818947A1 (de) 1978-11-02
IE46769B1 (en) 1983-09-21
DD135905A5 (de) 1979-06-06
CS198297B2 (en) 1980-05-30
IT7867959A0 (it) 1978-04-27
GB1572976A (en) 1980-08-13
US4183856A (en) 1980-01-15

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