JPS60243028A - インタ−フエロンの可溶化方法 - Google Patents

インタ−フエロンの可溶化方法

Info

Publication number
JPS60243028A
JPS60243028A JP59086972A JP8697284A JPS60243028A JP S60243028 A JPS60243028 A JP S60243028A JP 59086972 A JP59086972 A JP 59086972A JP 8697284 A JP8697284 A JP 8697284A JP S60243028 A JPS60243028 A JP S60243028A
Authority
JP
Japan
Prior art keywords
interferon
amino acid
acid
solubilizing
lysine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59086972A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0558000B2 (enExample
Inventor
Yasuki Katou
泰己 加藤
Eiji Hayakawa
栄治 早川
Kunitoshi Furuya
古家　邦敏
Akira Kondo
明 近藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP59086972A priority Critical patent/JPS60243028A/ja
Priority to DE8585104849T priority patent/DE3579942D1/de
Priority to EP85104849A priority patent/EP0163111B1/en
Priority to CA000479841A priority patent/CA1264665A/en
Priority to US06/726,971 priority patent/US4675183A/en
Publication of JPS60243028A publication Critical patent/JPS60243028A/ja
Publication of JPH0558000B2 publication Critical patent/JPH0558000B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP59086972A 1984-04-28 1984-04-28 インタ−フエロンの可溶化方法 Granted JPS60243028A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP59086972A JPS60243028A (ja) 1984-04-28 1984-04-28 インタ−フエロンの可溶化方法
DE8585104849T DE3579942D1 (de) 1984-04-28 1985-04-22 Verfahren zum loesbarmachen von interferon.
EP85104849A EP0163111B1 (en) 1984-04-28 1985-04-22 Method for solubilization of interferon
CA000479841A CA1264665A (en) 1984-04-28 1985-04-23 Method for solubilization of interferon
US06/726,971 US4675183A (en) 1984-04-28 1985-04-25 Method for solubilization of interferon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59086972A JPS60243028A (ja) 1984-04-28 1984-04-28 インタ−フエロンの可溶化方法

Publications (2)

Publication Number Publication Date
JPS60243028A true JPS60243028A (ja) 1985-12-03
JPH0558000B2 JPH0558000B2 (enExample) 1993-08-25

Family

ID=13901785

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59086972A Granted JPS60243028A (ja) 1984-04-28 1984-04-28 インタ−フエロンの可溶化方法

Country Status (5)

Country Link
US (1) US4675183A (enExample)
EP (1) EP0163111B1 (enExample)
JP (1) JPS60243028A (enExample)
CA (1) CA1264665A (enExample)
DE (1) DE3579942D1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008031186A (ja) * 2002-02-22 2008-02-14 Schering Corp 抗新生物薬剤、特にテモゾロミドの薬学的処方物、その同一物の製造方法および使用方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168008A3 (en) * 1984-07-10 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
US5183746A (en) * 1986-10-27 1993-02-02 Schering Aktiengesellschaft Formulation processes for pharmaceutical compositions of recombinant β-
US4895716A (en) * 1987-06-09 1990-01-23 Biogen, Inc. Stabilized formulations of gamma interferons
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
DE3744542B4 (de) * 1987-12-30 2004-06-03 Hoerrmann, Wilhelm, Dr. Pharmazeutische Verwendung von L-δ-Hydroxylysin
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
AU4803890A (en) * 1988-12-15 1990-07-10 Invitron Corporation Use of basic amino acids to solubilize immunoglobulins
US5358708A (en) * 1993-01-29 1994-10-25 Schering Corporation Stabilization of protein formulations
US6270757B1 (en) * 1994-04-21 2001-08-07 Genetics Institute, Inc. Formulations for IL-11
US6399296B1 (en) * 1994-07-20 2002-06-04 The General Hospital Corporation Interaction trap systems for detecting protein interactions
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
WO1996024369A1 (en) * 1995-02-06 1996-08-15 Genetics Institute, Inc. Formulations for il-12
US6540993B1 (en) * 1995-06-27 2003-04-01 Wyeth Method of treating inflammatory bowel disease using a topical formulation of IL-11
US6126933A (en) * 1995-06-27 2000-10-03 Genetics Institute Methods of treating inflammatory bowel diseases by administering IL-11
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
KR101042660B1 (ko) * 1996-12-24 2011-06-20 바이오겐 아이덱 엠에이 인코포레이티드 안정한 액체 인터페론 제제
US6887462B2 (en) * 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
UY27373A1 (es) * 2001-07-09 2003-02-28 Schering Ag Formulaciones de interferón beta-humano
EP1938798A1 (en) * 2002-02-22 2008-07-02 Schering Corporation Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same
JP2006509825A (ja) * 2002-12-13 2006-03-23 大塚製薬株式会社 経肺投与用インターフェロン−γ凍結乾燥組成物及びその吸入システム
US20070071840A1 (en) * 2005-09-27 2007-03-29 Sridevi Dhanaraj Method for treatment of cartilage disorders with centella extract
EP2409700A1 (en) * 2007-05-08 2012-01-25 Schering Corporation Methods of treatment using intravenous formulations comprising temozolomide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58146504A (ja) * 1981-12-23 1983-09-01 シエリング・コーポレーシヨン α―インターフェロン製剤およびその製造方法
JPS59106428A (ja) * 1982-11-24 1984-06-20 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 精製された生物学的に活性なモノマ−状インタ−フエロンの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5821691A (ja) * 1981-07-29 1983-02-08 Mochida Pharmaceut Co Ltd α−及びβ−インタ−フェロンの精製方法
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
JPS59181223A (ja) * 1983-03-29 1984-10-15 Sumitomo Chem Co Ltd インタ−フエロンの安定化法
JPS59181224A (ja) * 1983-03-29 1984-10-15 Sumitomo Chem Co Ltd 安定なインタ−フエロン製剤の製法
EP0168008A3 (en) * 1984-07-10 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58146504A (ja) * 1981-12-23 1983-09-01 シエリング・コーポレーシヨン α―インターフェロン製剤およびその製造方法
JPS59106428A (ja) * 1982-11-24 1984-06-20 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 精製された生物学的に活性なモノマ−状インタ−フエロンの製造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008031186A (ja) * 2002-02-22 2008-02-14 Schering Corp 抗新生物薬剤、特にテモゾロミドの薬学的処方物、その同一物の製造方法および使用方法

Also Published As

Publication number Publication date
JPH0558000B2 (enExample) 1993-08-25
US4675183A (en) 1987-06-23
EP0163111A2 (en) 1985-12-04
EP0163111B1 (en) 1990-10-03
CA1264665A (en) 1990-01-23
EP0163111A3 (en) 1987-09-30
DE3579942D1 (de) 1990-11-08

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