JPS60241884A - 自動サイクリング反応装置およびこれを用いる自動分析装置 - Google Patents

自動サイクリング反応装置およびこれを用いる自動分析装置

Info

Publication number
JPS60241884A
JPS60241884A JP59097341A JP9734184A JPS60241884A JP S60241884 A JPS60241884 A JP S60241884A JP 59097341 A JP59097341 A JP 59097341A JP 9734184 A JP9734184 A JP 9734184A JP S60241884 A JPS60241884 A JP S60241884A
Authority
JP
Japan
Prior art keywords
reaction
temperature
cycling
liquid
dispensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59097341A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6212986B2 (enExample
Inventor
Yoshiyuki Suzuki
義之 鈴木
Naohiko Kato
尚彦 加藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tokyo NUC
Original Assignee
University of Tokyo NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tokyo NUC filed Critical University of Tokyo NUC
Priority to JP59097341A priority Critical patent/JPS60241884A/ja
Priority to EP85303432A priority patent/EP0171140B1/en
Priority to US06/734,215 priority patent/US4981801A/en
Priority to DE85303432T priority patent/DE3587531T2/de
Publication of JPS60241884A publication Critical patent/JPS60241884A/ja
Publication of JPS6212986B2 publication Critical patent/JPS6212986B2/ja
Granted legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • C12M21/18Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00356Holding samples at elevated temperature (incubation)
    • G01N2035/00366Several different temperatures used
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00356Holding samples at elevated temperature (incubation)
    • G01N2035/00386Holding samples at elevated temperature (incubation) using fluid heat transfer medium
    • G01N2035/00396Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00435Refrigerated reagent storage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00445Other cooling arrangements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0401Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418Plate elements with several rows of samples
    • G01N2035/042Plate elements with several rows of samples moved independently, e.g. by fork manipulator
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1048General features of the devices using the transfer device for another function
    • G01N2035/1058General features of the devices using the transfer device for another function for mixing
    • G01N2035/106General features of the devices using the transfer device for another function for mixing by sucking and blowing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004Cleaning sample transfer devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP59097341A 1984-05-15 1984-05-15 自動サイクリング反応装置およびこれを用いる自動分析装置 Granted JPS60241884A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59097341A JPS60241884A (ja) 1984-05-15 1984-05-15 自動サイクリング反応装置およびこれを用いる自動分析装置
EP85303432A EP0171140B1 (en) 1984-05-15 1985-05-15 Automatic cycling reaction apparatus and automatic analyzing apparatus using the same
US06/734,215 US4981801A (en) 1984-05-15 1985-05-15 Automatic cycling reaction apparatus and automatic analyzing apparatus using the same
DE85303432T DE3587531T2 (de) 1984-05-15 1985-05-15 Automatisches Gerät für Zyklisierungsreaktionen sowie dieses benutzende automatische Analysegerät.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59097341A JPS60241884A (ja) 1984-05-15 1984-05-15 自動サイクリング反応装置およびこれを用いる自動分析装置

Publications (2)

Publication Number Publication Date
JPS60241884A true JPS60241884A (ja) 1985-11-30
JPS6212986B2 JPS6212986B2 (enExample) 1987-03-23

Family

ID=14189774

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59097341A Granted JPS60241884A (ja) 1984-05-15 1984-05-15 自動サイクリング反応装置およびこれを用いる自動分析装置

Country Status (4)

Country Link
US (1) US4981801A (enExample)
EP (1) EP0171140B1 (enExample)
JP (1) JPS60241884A (enExample)
DE (1) DE3587531T2 (enExample)

Cited By (8)

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US5602756A (en) * 1990-11-29 1997-02-11 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
JP2002513936A (ja) * 1998-05-01 2002-05-14 ジェン−プロウブ インコーポレイテッド 自動化診断用分析器および方法
JP2003329696A (ja) * 2002-05-15 2003-11-19 Horiba Ltd 化学発光酵素免疫測定装置
WO2008102772A1 (ja) * 2007-02-22 2008-08-28 Toyo Boseki Kabushiki Kaisha 核酸増幅装置
US7547516B2 (en) 2005-03-10 2009-06-16 Gen-Probe Incorporated Method for reducing the presence of amplification inhibitors in a reaction receptacle
JP2010537204A (ja) * 2007-08-28 2010-12-02 コーベット リサーチ プロプライエタリー リミテッド 選択的に開放することが可能なポートを有する熱サイクル適用デバイス。
US9915613B2 (en) 2011-02-24 2018-03-13 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
JP2019509506A (ja) * 2016-03-21 2019-04-04 シァメンタレントバイオメディカルテクノロジー カンパニーリミテッドXiamen Talent Biomedical Technology Company, Ltd. 生物サンプルスライドの全自動処理装置及び方法

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US5038852A (en) * 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5333675C1 (en) * 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
JPH0634932B2 (ja) * 1987-04-06 1994-05-11 日本テクトロン株式会社 試薬ボトルテ−ブルの温度調整構造
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US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
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US20030124652A1 (en) * 2001-12-21 2003-07-03 Novazyme Pharmaceuticals, Inc. Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells
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US8476034B2 (en) * 2003-07-10 2013-07-02 General Atomics Methods and compositions for assaying homocysteine
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CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的系统和方法
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JP2013134142A (ja) * 2011-12-26 2013-07-08 Hitachi High-Technologies Corp 自動分析装置
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CN112094734A (zh) * 2019-06-18 2020-12-18 广州市汉威信息科技有限公司 一种用于癌症细胞基因突变研究的高通量基因测序装置
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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602756A (en) * 1990-11-29 1997-02-11 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5710381A (en) * 1990-11-29 1998-01-20 The Perkin-Elmer Corporation Two piece holder for PCR sample tubes
US7560255B2 (en) 1998-05-01 2009-07-14 Gen-Probe Incorporated Automated process for detecting the presence of a target nucleic acid in a sample
US7638337B2 (en) 1998-05-01 2009-12-29 Gen-Probe Incorporated System for agitating the fluid contents of a container
US7267795B2 (en) 1998-05-01 2007-09-11 Gen-Probe Incorporated Incubator for use in an automated diagnostic analyzer
US7384600B2 (en) 1998-05-01 2008-06-10 Gen-Probe Incorporated Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer
US7396509B2 (en) 1998-05-01 2008-07-08 Gen-Probe Incorporated Instrument for detecting light emitted by the contents of a reaction receptacle
US9598723B2 (en) 1998-05-01 2017-03-21 Gen-Probe Incorporated Automated analyzer for performing a nucleic acid-based assay
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EP0171140A2 (en) 1986-02-12
JPS6212986B2 (enExample) 1987-03-23
US4981801A (en) 1991-01-01
DE3587531T2 (de) 1994-01-13
EP0171140B1 (en) 1993-08-18
EP0171140A3 (en) 1987-08-05

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