JPS60241884A - 自動サイクリング反応装置およびこれを用いる自動分析装置 - Google Patents
自動サイクリング反応装置およびこれを用いる自動分析装置Info
- Publication number
- JPS60241884A JPS60241884A JP59097341A JP9734184A JPS60241884A JP S60241884 A JPS60241884 A JP S60241884A JP 59097341 A JP59097341 A JP 59097341A JP 9734184 A JP9734184 A JP 9734184A JP S60241884 A JPS60241884 A JP S60241884A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- temperature
- cycling
- liquid
- dispensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006243 chemical reaction Methods 0.000 title claims description 244
- 230000001351 cycling effect Effects 0.000 title claims description 110
- 238000004458 analytical method Methods 0.000 title claims description 25
- 239000007788 liquid Substances 0.000 claims description 59
- 102000004190 Enzymes Human genes 0.000 claims description 24
- 108090000790 Enzymes Proteins 0.000 claims description 24
- 230000035484 reaction time Effects 0.000 claims description 9
- 238000004064 recycling Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 39
- 238000004140 cleaning Methods 0.000 description 38
- 239000012295 chemical reaction liquid Substances 0.000 description 28
- 230000007246 mechanism Effects 0.000 description 26
- 238000000034 method Methods 0.000 description 21
- 239000000126 substance Substances 0.000 description 18
- 230000002255 enzymatic effect Effects 0.000 description 15
- 238000005259 measurement Methods 0.000 description 15
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 14
- 230000003321 amplification Effects 0.000 description 13
- 238000003199 nucleic acid amplification method Methods 0.000 description 13
- 230000002528 anti-freeze Effects 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000013076 target substance Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000000758 substrate Substances 0.000 description 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 6
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 6
- 235000011090 malic acid Nutrition 0.000 description 6
- 239000001630 malic acid Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000002699 waste material Substances 0.000 description 6
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 4
- 235000014676 Phragmites communis Nutrition 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 101710088194 Dehydrogenase Proteins 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 210000004381 amniotic fluid Anatomy 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical class C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 101150111329 ACE-1 gene Proteins 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 241000257465 Echinoidea Species 0.000 description 1
- 208000022471 Fetal disease Diseases 0.000 description 1
- 208000027472 Galactosemias Diseases 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- DSUJHXYAWUOXCC-UHFFFAOYSA-N acetaldehyde;ethanol Chemical compound CCO.CC=O DSUJHXYAWUOXCC-UHFFFAOYSA-N 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000010799 enzyme reaction rate Methods 0.000 description 1
- 238000005558 fluorometry Methods 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00366—Several different temperatures used
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
- G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00435—Refrigerated reagent storage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00445—Other cooling arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/042—Plate elements with several rows of samples moved independently, e.g. by fork manipulator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1058—General features of the devices using the transfer device for another function for mixing
- G01N2035/106—General features of the devices using the transfer device for another function for mixing by sucking and blowing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59097341A JPS60241884A (ja) | 1984-05-15 | 1984-05-15 | 自動サイクリング反応装置およびこれを用いる自動分析装置 |
| EP85303432A EP0171140B1 (en) | 1984-05-15 | 1985-05-15 | Automatic cycling reaction apparatus and automatic analyzing apparatus using the same |
| US06/734,215 US4981801A (en) | 1984-05-15 | 1985-05-15 | Automatic cycling reaction apparatus and automatic analyzing apparatus using the same |
| DE85303432T DE3587531T2 (de) | 1984-05-15 | 1985-05-15 | Automatisches Gerät für Zyklisierungsreaktionen sowie dieses benutzende automatische Analysegerät. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59097341A JPS60241884A (ja) | 1984-05-15 | 1984-05-15 | 自動サイクリング反応装置およびこれを用いる自動分析装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60241884A true JPS60241884A (ja) | 1985-11-30 |
| JPS6212986B2 JPS6212986B2 (enExample) | 1987-03-23 |
Family
ID=14189774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59097341A Granted JPS60241884A (ja) | 1984-05-15 | 1984-05-15 | 自動サイクリング反応装置およびこれを用いる自動分析装置 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4981801A (enExample) |
| EP (1) | EP0171140B1 (enExample) |
| JP (1) | JPS60241884A (enExample) |
| DE (1) | DE3587531T2 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602756A (en) * | 1990-11-29 | 1997-02-11 | The Perkin-Elmer Corporation | Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control |
| JP2002513936A (ja) * | 1998-05-01 | 2002-05-14 | ジェン−プロウブ インコーポレイテッド | 自動化診断用分析器および方法 |
| JP2003329696A (ja) * | 2002-05-15 | 2003-11-19 | Horiba Ltd | 化学発光酵素免疫測定装置 |
| WO2008102772A1 (ja) * | 2007-02-22 | 2008-08-28 | Toyo Boseki Kabushiki Kaisha | 核酸増幅装置 |
| US7547516B2 (en) | 2005-03-10 | 2009-06-16 | Gen-Probe Incorporated | Method for reducing the presence of amplification inhibitors in a reaction receptacle |
| JP2010537204A (ja) * | 2007-08-28 | 2010-12-02 | コーベット リサーチ プロプライエタリー リミテッド | 選択的に開放することが可能なポートを有する熱サイクル適用デバイス。 |
| US9915613B2 (en) | 2011-02-24 | 2018-03-13 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
| JP2019509506A (ja) * | 2016-03-21 | 2019-04-04 | シァメンタレントバイオメディカルテクノロジー カンパニーリミテッドXiamen Talent Biomedical Technology Company, Ltd. | 生物サンプルスライドの全自動処理装置及び方法 |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986001824A1 (en) * | 1984-09-18 | 1986-03-27 | Sumitomo Electric Industries, Ltd. | Apparatus for sorting cells |
| US5656493A (en) * | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
| US5038852A (en) * | 1986-02-25 | 1991-08-13 | Cetus Corporation | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US5333675C1 (en) * | 1986-02-25 | 2001-05-01 | Perkin Elmer Corp | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| JPH0634932B2 (ja) * | 1987-04-06 | 1994-05-11 | 日本テクトロン株式会社 | 試薬ボトルテ−ブルの温度調整構造 |
| CA2016981C (en) * | 1989-06-12 | 1994-09-27 | Mark Joseph Devaney, Jr. | Temperature control device and reaction vessel |
| US7081226B1 (en) | 1996-06-04 | 2006-07-25 | University Of Utah Research Foundation | System and method for fluorescence monitoring |
| US6787338B2 (en) * | 1990-06-04 | 2004-09-07 | The University Of Utah | Method for rapid thermal cycling of biological samples |
| US5935522A (en) * | 1990-06-04 | 1999-08-10 | University Of Utah Research Foundation | On-line DNA analysis system with rapid thermal cycling |
| US7273749B1 (en) | 1990-06-04 | 2007-09-25 | University Of Utah Research Foundation | Container for carrying out and monitoring biological processes |
| US5455175A (en) * | 1990-06-04 | 1995-10-03 | University Of Utah Research Foundation | Rapid thermal cycling device |
| AU649770B2 (en) * | 1991-01-25 | 1994-06-02 | Societe Prolabo | Apparatus for simultaneous treatment, in a moist medium, on a plurality of samples, and utilisation of the said apparatus |
| US5270183A (en) * | 1991-02-08 | 1993-12-14 | Beckman Research Institute Of The City Of Hope | Device and method for the automated cycling of solutions between two or more temperatures |
| CA2065719A1 (en) | 1991-04-30 | 1992-10-31 | John B. Findlay | Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle |
| DK0610396T3 (da) * | 1991-10-23 | 2001-01-29 | Baylor College Medicine | Fingeraftryksidentifikation af bakteriestammer med anvendelse af repetitiv DNA-sekvensamplifikation |
| JPH06507976A (ja) * | 1991-12-18 | 1994-09-08 | バクスター、ダイアグノスチックス、インコーポレイテッド | 中央処理ハブを使用する多数分析操作を行うためのシステム |
| US5384024A (en) * | 1992-03-13 | 1995-01-24 | Applied Biosystems, Inc. | Capillary electrophoresis |
| CA2130517C (en) * | 1993-09-10 | 1999-10-05 | Walter Fassbind | Array of reaction containers for an apparatus for automatic performance of temperature cycles |
| CA2130013C (en) * | 1993-09-10 | 1999-03-30 | Rolf Moser | Apparatus for automatic performance of temperature cycles |
| US5525300A (en) * | 1993-10-20 | 1996-06-11 | Stratagene | Thermal cycler including a temperature gradient block |
| EP0739241B1 (en) * | 1994-01-11 | 1998-08-12 | Abbott Laboratories | Apparatus and method for thermal cycling nucleic acid assays |
| US5840573A (en) * | 1994-02-01 | 1998-11-24 | Fields; Robert E. | Molecular analyzer and method of use |
| US5499872A (en) * | 1994-03-14 | 1996-03-19 | Baxter; Michael | Turntable mixer apparatus |
| DE4409436A1 (de) * | 1994-03-19 | 1995-09-21 | Boehringer Mannheim Gmbh | Verfahren zur Bearbeitung von Nukleinsäuren |
| WO1997041437A1 (en) * | 1996-05-01 | 1997-11-06 | Sanko Junyaku Co., Ltd. | Automatic immunoassay method and apparatus |
| AU726501B2 (en) | 1996-06-04 | 2000-11-09 | University Of Utah Research Foundation | Monitoring hybridization during PCR |
| ATE390491T1 (de) * | 1996-06-04 | 2008-04-15 | Univ Utah Res Found | Behälter zum durchführen und beobachten biologischer prozesse |
| DE29623597U1 (de) * | 1996-11-08 | 1999-01-07 | Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg | Temperierblock mit Temperiereinrichtungen |
| US6323035B1 (en) | 1997-09-24 | 2001-11-27 | Glaxo Wellcome, Inc. | Systems and methods for handling and manipulating multi-well plates |
| DE29720432U1 (de) * | 1997-11-19 | 1999-03-25 | Heimberg, Wolfgang, Dr., 85560 Ebersberg | Roboter |
| WO1999028038A1 (en) * | 1997-11-28 | 1999-06-10 | Cortecs Diagnostics Limited | Device and apparatus for conducting an assay |
| US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
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- 1985-05-15 DE DE85303432T patent/DE3587531T2/de not_active Expired - Fee Related
- 1985-05-15 EP EP85303432A patent/EP0171140B1/en not_active Expired - Lifetime
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| JP2010537204A (ja) * | 2007-08-28 | 2010-12-02 | コーベット リサーチ プロプライエタリー リミテッド | 選択的に開放することが可能なポートを有する熱サイクル適用デバイス。 |
| US9915613B2 (en) | 2011-02-24 | 2018-03-13 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
| US10641707B2 (en) | 2011-02-24 | 2020-05-05 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
| JP2019509506A (ja) * | 2016-03-21 | 2019-04-04 | シァメンタレントバイオメディカルテクノロジー カンパニーリミテッドXiamen Talent Biomedical Technology Company, Ltd. | 生物サンプルスライドの全自動処理装置及び方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3587531D1 (de) | 1993-09-23 |
| EP0171140A2 (en) | 1986-02-12 |
| JPS6212986B2 (enExample) | 1987-03-23 |
| US4981801A (en) | 1991-01-01 |
| DE3587531T2 (de) | 1994-01-13 |
| EP0171140B1 (en) | 1993-08-18 |
| EP0171140A3 (en) | 1987-08-05 |
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