JPS60224617A - 経口投与用の製剤及びその水中油型エマルジヨン凍結乾燥による調製方法 - Google Patents

経口投与用の製剤及びその水中油型エマルジヨン凍結乾燥による調製方法

Info

Publication number
JPS60224617A
JPS60224617A JP60064081A JP6408185A JPS60224617A JP S60224617 A JPS60224617 A JP S60224617A JP 60064081 A JP60064081 A JP 60064081A JP 6408185 A JP6408185 A JP 6408185A JP S60224617 A JPS60224617 A JP S60224617A
Authority
JP
Japan
Prior art keywords
preparing
preparation according
aqueous phase
preparation
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60064081A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0581567B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
ルイ、ラフオン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of JPS60224617A publication Critical patent/JPS60224617A/ja
Publication of JPH0581567B2 publication Critical patent/JPH0581567B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
JP60064081A 1984-03-30 1985-03-29 経口投与用の製剤及びその水中油型エマルジヨン凍結乾燥による調製方法 Granted JPS60224617A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8405058A FR2561916B1 (fr) 1984-03-30 1984-03-30 Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
FR8405058 1984-03-30

Publications (2)

Publication Number Publication Date
JPS60224617A true JPS60224617A (ja) 1985-11-09
JPH0581567B2 JPH0581567B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-11-15

Family

ID=9302670

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60064081A Granted JPS60224617A (ja) 1984-03-30 1985-03-29 経口投与用の製剤及びその水中油型エマルジヨン凍結乾燥による調製方法

Country Status (10)

Country Link
US (1) US4616047A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0159237B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS60224617A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE34078T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU567271B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1233119A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3562555D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8607011A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2561916B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA852168B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60239417A (ja) * 1984-05-15 1985-11-28 Sankyo Co Ltd エマルシヨン凍結乾燥製剤の製法
WO1991007962A1 (en) * 1989-12-01 1991-06-13 Nippon Shinyaku Co., Ltd. Fat emulsion
WO1991007964A1 (en) * 1989-12-01 1991-06-13 Nippon Shinyaku Co., Ltd. Fat emulsion
JP2001089398A (ja) * 1999-09-20 2001-04-03 Meiji Seika Kaisha Ltd 経口投与用の凍結乾燥製剤及びその製造方法
JP2004524370A (ja) * 2001-02-23 2004-08-12 シーマ・ラブス、インコーポレイテッド 経口投与固形製剤としてのエマルジョン
JP2011519349A (ja) * 2008-03-20 2011-07-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 凍結乾燥ナノエマルション

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US4572915A (en) * 1984-05-01 1986-02-25 Bioglan Laboratories Clear micellized solutions of fat soluble essential nutrients
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
IL86892A (en) * 1987-07-08 1993-04-04 Lafon Labor Filter comprising a material obtained by freeze-drying, its preparation and its use, especially in pharmacy
FR2645740B1 (fr) * 1989-04-12 1994-01-28 Fabre Cosmetique Pierre Compositions topiques triphasiques et extemporanement emulsionnables utiles en cosmetologie et/ou dermatologie
US5039540A (en) * 1989-08-14 1991-08-13 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5079018A (en) * 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5188825A (en) * 1989-12-28 1993-02-23 Iles Martin C Freeze-dried dosage forms and methods for preparing the same
KR930006431B1 (ko) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
WO1992017162A1 (en) * 1991-04-05 1992-10-15 Warner-Lambert Company Lyophilized emulsion
GB9200247D0 (en) * 1992-01-07 1992-02-26 Erba Carlo Spa Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
HUT75616A (en) * 1992-03-17 1997-05-28 Pfizer Method for prooucing porous delivery devices
US5298261A (en) * 1992-04-20 1994-03-29 Oregon Freeze Dry, Inc. Rapidly distintegrating tablet
EP0663818A4 (en) * 1992-09-03 1996-04-24 Ibah Inc TASTE-COVERING PHARMACEUTICAL SUMMARY AND METHOD FOR PRODUCING THE SAME.
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US5382437A (en) * 1993-10-25 1995-01-17 Hunter Research Corporation Frozen liquified gas composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
GB9421836D0 (en) * 1994-10-28 1994-12-14 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
KR0181252B1 (ko) * 1996-12-31 1999-03-20 박원훈 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법
GB9702799D0 (en) * 1997-02-12 1997-04-02 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms
AU8977698A (en) * 1997-07-25 1999-02-16 Elan Corporation, Plc A process for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets
DE69935433T2 (de) * 1998-07-30 2007-10-25 Point Biomedical Corp., San Carlos Neuer wirkstoffträger für die gefriertrocknung von wässrigen suspensionen von mikropartikeln
US20040013613A1 (en) * 2001-05-18 2004-01-22 Jain Rajeev A Rapidly disintegrating solid oral dosage form
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US6316029B1 (en) 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
JP2004521894A (ja) * 2001-01-26 2004-07-22 シェーリング　コーポレイション 胆汁酸金属イオン封鎖剤およびステロール吸収阻害剤の併用および血管適応症の治療
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1353694T1 (sl) * 2001-01-26 2008-06-30 Schering Corp Kombinacije ezetimiba z aspirinom za zdravljenejevaskularnih stanj
CA2434488A1 (en) * 2001-01-26 2002-08-01 Harry R. Davis Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
SK287746B6 (sk) * 2001-01-26 2011-08-04 Schering Corporation Použitie substituovaných azetidinónových zlúčenín na liečenie sitosterolémie
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PT1385548E (pt) * 2001-01-26 2007-08-24 Schering Corp Combinações de um inibidor ou de inibidores de absorção de esteróis com agente (s) para o tratamento de doenças vasculares
EP1392287B8 (en) * 2001-05-25 2007-01-10 Schering Corporation Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
NZ531060A (en) * 2001-09-21 2006-06-30 Schering Corp Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
ATE345793T1 (de) * 2001-09-21 2006-12-15 Schering Corp Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
WO2003030872A2 (en) * 2001-10-12 2003-04-17 Elan Pharma International Ltd. Compositions having a combination of particles for immediate release and for controlled release
EP1941878A1 (en) 2002-01-10 2008-07-09 Biovail Laboratories International Srl Sedative non-benzodiazepine formulations
JP2005526095A (ja) * 2002-03-20 2005-09-02 エラン ファーマ インターナショナル，リミティド 脆砕性の低い急速溶解投与剤型
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
JP4776233B2 (ja) * 2002-11-12 2011-09-21 エラン ファーマ インターナショナル，リミティド 摩損しにくくかつプルランを含む速崩壊性固形製剤
MXPA05009501A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
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US20050036977A1 (en) * 2003-08-11 2005-02-17 Dilip Gole Taste-masked resinate and preparation thereof
JP2007510659A (ja) * 2003-11-05 2007-04-26 シェーリング　コーポレイション 脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置
US8101226B2 (en) * 2005-03-08 2012-01-24 Nestec S.A. Extruded solid product for use in foodstuffs
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CA2907770C (en) 2013-03-22 2022-02-15 Nova Southeastern University Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
ES2954361T3 (es) 2017-09-08 2023-11-21 Insignis Therapeutics Inc Métodos de uso de dipivefrina
AU2019361136B2 (en) 2018-10-19 2025-08-14 Nova Southeastern University Sublingual epinephrine compositions including pH-modifying excipients and penetration enhancers and methods for use thereof
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JPS5296724A (en) * 1976-02-10 1977-08-13 Kyowa Hakko Kogyo Co Ltd Preparation of powdery products

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60239417A (ja) * 1984-05-15 1985-11-28 Sankyo Co Ltd エマルシヨン凍結乾燥製剤の製法
WO1991007962A1 (en) * 1989-12-01 1991-06-13 Nippon Shinyaku Co., Ltd. Fat emulsion
WO1991007964A1 (en) * 1989-12-01 1991-06-13 Nippon Shinyaku Co., Ltd. Fat emulsion
JP2001089398A (ja) * 1999-09-20 2001-04-03 Meiji Seika Kaisha Ltd 経口投与用の凍結乾燥製剤及びその製造方法
JP2004524370A (ja) * 2001-02-23 2004-08-12 シーマ・ラブス、インコーポレイテッド 経口投与固形製剤としてのエマルジョン
JP2011519349A (ja) * 2008-03-20 2011-07-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 凍結乾燥ナノエマルション

Also Published As

Publication number Publication date
DE3562555D1 (en) 1988-06-16
ES542483A0 (es) 1986-05-16
US4616047A (en) 1986-10-07
ES8607011A1 (es) 1986-05-16
ZA852168B (en) 1985-11-27
AU567271B2 (en) 1987-11-12
EP0159237B1 (en) 1988-05-11
JPH0581567B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-11-15
AU4015385A (en) 1985-10-03
FR2561916B1 (fr) 1987-12-11
FR2561916A1 (fr) 1985-10-04
CA1233119A (en) 1988-02-23
EP0159237A1 (en) 1985-10-23
ATE34078T1 (de) 1988-05-15

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