AU567271B2 - Lyophilization of oil in water emulsion to give galenic form for oral administration - Google Patents
Lyophilization of oil in water emulsion to give galenic form for oral administrationInfo
- Publication number
- AU567271B2 AU567271B2 AU40153/85A AU4015385A AU567271B2 AU 567271 B2 AU567271 B2 AU 567271B2 AU 40153/85 A AU40153/85 A AU 40153/85A AU 4015385 A AU4015385 A AU 4015385A AU 567271 B2 AU567271 B2 AU 567271B2
- Authority
- AU
- Australia
- Prior art keywords
- temperature
- lyophilization
- phase
- preparation
- galenic form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8405058A FR2561916B1 (fr) | 1984-03-30 | 1984-03-30 | Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau |
FR8405058 | 1984-03-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU4015385A AU4015385A (en) | 1985-10-03 |
AU567271B2 true AU567271B2 (en) | 1987-11-12 |
Family
ID=9302670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU40153/85A Expired AU567271B2 (en) | 1984-03-30 | 1985-03-20 | Lyophilization of oil in water emulsion to give galenic form for oral administration |
Country Status (10)
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
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US4572915A (en) * | 1984-05-01 | 1986-02-25 | Bioglan Laboratories | Clear micellized solutions of fat soluble essential nutrients |
JPS60239417A (ja) * | 1984-05-15 | 1985-11-28 | Sankyo Co Ltd | エマルシヨン凍結乾燥製剤の製法 |
IL78930A0 (en) * | 1985-07-29 | 1986-09-30 | Abbott Lab | Lyophilized emulsion compositions for parenteral administration |
DE3702029A1 (de) * | 1987-01-24 | 1988-08-04 | Basf Ag | Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung |
IL86892A (en) * | 1987-07-08 | 1993-04-04 | Lafon Labor | Filter comprising a material obtained by freeze-drying, its preparation and its use, especially in pharmacy |
FR2645740B1 (fr) * | 1989-04-12 | 1994-01-28 | Fabre Cosmetique Pierre | Compositions topiques triphasiques et extemporanement emulsionnables utiles en cosmetologie et/ou dermatologie |
US5039540A (en) * | 1989-08-14 | 1991-08-13 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
WO1991007964A1 (en) * | 1989-12-01 | 1991-06-13 | Nippon Shinyaku Co., Ltd. | Fat emulsion |
JP3074731B2 (ja) * | 1989-12-01 | 2000-08-07 | 日本新薬株式会社 | 脂肪乳剤 |
US5188825A (en) * | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
KR930006431B1 (ko) * | 1990-10-11 | 1993-07-16 | 재단법인 한국화학연구소 | 약물의 미세캡슐화 방법 |
WO1992017162A1 (en) * | 1991-04-05 | 1992-10-15 | Warner-Lambert Company | Lyophilized emulsion |
GB9200247D0 (en) * | 1992-01-07 | 1992-02-26 | Erba Carlo Spa | Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation |
IL101007A (en) * | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
HUT75616A (en) * | 1992-03-17 | 1997-05-28 | Pfizer | Method for prooucing porous delivery devices |
US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
EP0663818A4 (en) * | 1992-09-03 | 1996-04-24 | Ibah Inc | TASTE-COVERING PHARMACEUTICAL SUMMARY AND METHOD FOR PRODUCING THE SAME. |
DE4244122C1 (de) * | 1992-12-24 | 1994-06-01 | Sanol Arznei Schwarz Gmbh | Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation |
US5382437A (en) * | 1993-10-25 | 1995-01-17 | Hunter Research Corporation | Frozen liquified gas composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
GB9421836D0 (en) * | 1994-10-28 | 1994-12-14 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances |
KR0181252B1 (ko) * | 1996-12-31 | 1999-03-20 | 박원훈 | 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법 |
GB9702799D0 (en) * | 1997-02-12 | 1997-04-02 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms |
AU8977698A (en) * | 1997-07-25 | 1999-02-16 | Elan Corporation, Plc | A process for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets |
DE69935433T2 (de) * | 1998-07-30 | 2007-10-25 | Point Biomedical Corp., San Carlos | Neuer wirkstoffträger für die gefriertrocknung von wässrigen suspensionen von mikropartikeln |
US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
JP2001089398A (ja) * | 1999-09-20 | 2001-04-03 | Meiji Seika Kaisha Ltd | 経口投与用の凍結乾燥製剤及びその製造方法 |
US6316029B1 (en) | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
JP2004521894A (ja) * | 2001-01-26 | 2004-07-22 | シェーリング コーポレイション | 胆汁酸金属イオン封鎖剤およびステロール吸収阻害剤の併用および血管適応症の治療 |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
SI1353694T1 (sl) * | 2001-01-26 | 2008-06-30 | Schering Corp | Kombinacije ezetimiba z aspirinom za zdravljenejevaskularnih stanj |
CA2434488A1 (en) * | 2001-01-26 | 2002-08-01 | Harry R. Davis | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
SK287746B6 (sk) * | 2001-01-26 | 2011-08-04 | Schering Corporation | Použitie substituovaných azetidinónových zlúčenín na liečenie sitosterolémie |
PT1353696E (pt) * | 2001-01-26 | 2007-02-28 | Schering Corp | Combinações de activador (es) do receptor activado por proliferador do peroxisoma (ppar) e inibidor (es) da absorção de esterol e tratamentos para indicações vasculares |
PT1385548E (pt) * | 2001-01-26 | 2007-08-24 | Schering Corp | Combinações de um inibidor ou de inibidores de absorção de esteróis com agente (s) para o tratamento de doenças vasculares |
CA2437762C (en) * | 2001-02-23 | 2010-08-10 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
EP1392287B8 (en) * | 2001-05-25 | 2007-01-10 | Schering Corporation | Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
NZ531060A (en) * | 2001-09-21 | 2006-06-30 | Schering Corp | Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s) |
ATE345793T1 (de) * | 2001-09-21 | 2006-12-15 | Schering Corp | Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
WO2003030872A2 (en) * | 2001-10-12 | 2003-04-17 | Elan Pharma International Ltd. | Compositions having a combination of particles for immediate release and for controlled release |
EP1941878A1 (en) | 2002-01-10 | 2008-07-09 | Biovail Laboratories International Srl | Sedative non-benzodiazepine formulations |
JP2005526095A (ja) * | 2002-03-20 | 2005-09-02 | エラン ファーマ インターナショナル,リミティド | 脆砕性の低い急速溶解投与剤型 |
WO2004043457A1 (en) * | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
JP4776233B2 (ja) * | 2002-11-12 | 2011-09-21 | エラン ファーマ インターナショナル,リミティド | 摩損しにくくかつプルランを含む速崩壊性固形製剤 |
MXPA05009501A (es) | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
MXPA05009502A (es) * | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
ATE406364T1 (de) | 2003-03-07 | 2008-09-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
JP2007510659A (ja) * | 2003-11-05 | 2007-04-26 | シェーリング コーポレイション | 脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置 |
US8101226B2 (en) * | 2005-03-08 | 2012-01-24 | Nestec S.A. | Extruded solid product for use in foodstuffs |
CA2618370A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
WO2011109340A1 (en) | 2010-03-01 | 2011-09-09 | Nova Southeastern University | Epinephrine nanop articles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
US20160045457A1 (en) | 2005-09-09 | 2016-02-18 | Ousama Rachid | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
US9877921B2 (en) | 2005-09-09 | 2018-01-30 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
US20080031947A1 (en) * | 2006-07-24 | 2008-02-07 | Cima Labs Inc. | Orally dissolvable/disintegrable lyophilized dosage forms containing protected |
DE102008015366A1 (de) * | 2008-03-20 | 2009-09-24 | Merck Patent Gmbh | Lyophilisierte Nanoemulsion |
EP2359812A1 (en) * | 2010-01-18 | 2011-08-24 | Cephalon France | Oral lyophilised compositions |
WO2011086194A1 (en) | 2010-01-18 | 2011-07-21 | Cephalon France | Improved oral lysophilisates containing pvp/va |
SG10201506873WA (en) | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Fast-dissolve dosage forms of 5-ht2c agonists |
TR201007613A2 (tr) * | 2010-09-16 | 2012-04-24 | Yed�Tepe �N�Vers�Tes� | Liyofilize biyopestisit efervesan granül ve üretim yöntemi |
CA2819663C (en) | 2010-12-02 | 2019-12-24 | Aptalis Pharmatech, Inc. | Rapidly dispersing granules, orally disintegrating tablets and methods |
US20140242177A1 (en) | 2011-10-21 | 2014-08-28 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
EP2861224A4 (en) | 2012-06-15 | 2015-11-18 | Univ Nova Southeastern | EPINEPHRINNANOPARTICLES, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE USE THEREOF FOR TREATING SUFFERING SUFFERING TO EPINEPHRIN |
CA2907770C (en) | 2013-03-22 | 2022-02-15 | Nova Southeastern University | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
ES2954361T3 (es) | 2017-09-08 | 2023-11-21 | Insignis Therapeutics Inc | Métodos de uso de dipivefrina |
AU2019361136B2 (en) | 2018-10-19 | 2025-08-14 | Nova Southeastern University | Sublingual epinephrine compositions including pH-modifying excipients and penetration enhancers and methods for use thereof |
US11213484B2 (en) | 2019-03-01 | 2022-01-04 | Insignis Therapeutics, Inc. | Dipivefrin orally disintegrating tablet formulations |
WO2021062374A1 (en) | 2019-09-27 | 2021-04-01 | Duke University | Tabletization of peptide self-assemblies and methods of making and using the same |
GB2638418A (en) * | 2024-02-21 | 2025-08-27 | Novumgen Ltd | An orodispersible tablet of spironolactone and its process of preparation |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2520939A (en) * | 1947-01-27 | 1950-09-05 | Inst Divi Thomae Foundation | Process of concentrating milk |
GB806723A (en) * | 1955-09-02 | 1958-12-31 | Ici Ltd | New pharmaceutical compositions |
US3464834A (en) * | 1963-11-18 | 1969-09-02 | Grace W R & Co | Freeze-drying ice milk confections |
DE2017373A1 (de) * | 1969-04-15 | 1971-04-22 | Orsymonde S A , Paris | Lyophihsierte Produkte und Ver fahren zu ihrer Herstellung |
CH528266A (fr) * | 1969-11-26 | 1972-09-30 | Orsymonde | Procédé pour la préparation d'une composition lyophilisée à l'usage cosmétique ou hygiénique |
ZA738657B (en) * | 1973-01-05 | 1974-10-30 | Hoffmann La Roche | Emulsions |
GB1447988A (en) * | 1973-04-03 | 1976-09-02 | Orsymonde | Pharmaceutical compositions |
US4001944A (en) * | 1975-08-25 | 1977-01-11 | Parke, Davis & Company | Freeze-drying process |
US3961424A (en) * | 1975-08-28 | 1976-06-08 | General Foods Corporation | Process for freezing coffee extract prior to lyophilization |
JPS5296724A (en) * | 1976-02-10 | 1977-08-13 | Kyowa Hakko Kogyo Co Ltd | Preparation of powdery products |
JPS52125615A (en) * | 1976-04-09 | 1977-10-21 | Kyowa Hakko Kogyo Co Ltd | Method of making powdered products |
IL53427A0 (en) * | 1976-11-24 | 1978-01-31 | Lilly Co Eli | Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration |
US4273762A (en) * | 1979-12-03 | 1981-06-16 | Merck & Co., Inc. | Lyophilization process for live viral compositions |
US4295280A (en) * | 1980-03-17 | 1981-10-20 | American Home Products Corporation | Method of obtaining a lyophilized product |
US4521975A (en) * | 1981-05-04 | 1985-06-11 | Marquest Medical Products, Inc. | Lyophilizing and forming biologicals having a predetermined unit dosage |
FR2539626B2 (fr) * | 1983-01-25 | 1985-06-21 | Lafon Labor | Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede |
-
1984
- 1984-03-30 FR FR8405058A patent/FR2561916B1/fr not_active Expired
-
1985
- 1985-03-18 CA CA000476784A patent/CA1233119A/en not_active Expired
- 1985-03-20 AT AT85400528T patent/ATE34078T1/de not_active IP Right Cessation
- 1985-03-20 EP EP85400528A patent/EP0159237B1/en not_active Expired
- 1985-03-20 DE DE8585400528T patent/DE3562555D1/de not_active Expired
- 1985-03-20 AU AU40153/85A patent/AU567271B2/en not_active Expired
- 1985-03-21 US US06/714,686 patent/US4616047A/en not_active Expired - Lifetime
- 1985-03-22 ZA ZA852168A patent/ZA852168B/xx unknown
- 1985-03-29 ES ES542483A patent/ES8607011A1/es not_active Expired
- 1985-03-29 JP JP60064081A patent/JPS60224617A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DE3562555D1 (en) | 1988-06-16 |
ES542483A0 (es) | 1986-05-16 |
US4616047A (en) | 1986-10-07 |
ES8607011A1 (es) | 1986-05-16 |
ZA852168B (en) | 1985-11-27 |
EP0159237B1 (en) | 1988-05-11 |
JPH0581567B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-11-15 |
AU4015385A (en) | 1985-10-03 |
FR2561916B1 (fr) | 1987-12-11 |
FR2561916A1 (fr) | 1985-10-04 |
CA1233119A (en) | 1988-02-23 |
EP0159237A1 (en) | 1985-10-23 |
ATE34078T1 (de) | 1988-05-15 |
JPS60224617A (ja) | 1985-11-09 |
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