JPS60197684A - ベンゾ〔ａ〕キノリジン誘導体およびその塩 - Google Patents

ベンゾ〔ａ〕キノリジン誘導体およびその塩

Info

Publication number
JPS60197684A
JPS60197684A JP5467984A JP5467984A JPS60197684A JP S60197684 A JPS60197684 A JP S60197684A JP 5467984 A JP5467984 A JP 5467984A JP 5467984 A JP5467984 A JP 5467984A JP S60197684 A JPS60197684 A JP S60197684A
Authority
JP
Japan
Prior art keywords
compound
benzo
methyl
carboxylic acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5467984A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0477B2 (e
Inventor
Junichi Matsumoto
純一 松本
Hiroshi Egawa
宏 江川
Koshi Miyamoto
宮本　皓之
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP5467984A priority Critical patent/JPS60197684A/ja
Publication of JPS60197684A publication Critical patent/JPS60197684A/ja
Publication of JPH0477B2 publication Critical patent/JPH0477B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP5467984A 1984-03-21 1984-03-21 ベンゾ〔ａ〕キノリジン誘導体およびその塩 Granted JPS60197684A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5467984A JPS60197684A (ja) 1984-03-21 1984-03-21 ベンゾ〔ａ〕キノリジン誘導体およびその塩

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5467984A JPS60197684A (ja) 1984-03-21 1984-03-21 ベンゾ〔ａ〕キノリジン誘導体およびその塩

Publications (2)

Publication Number Publication Date
JPS60197684A true JPS60197684A (ja) 1985-10-07
JPH0477B2 JPH0477B2 (e) 1992-01-06

Family

ID=12977472

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5467984A Granted JPS60197684A (ja) 1984-03-21 1984-03-21 ベンゾ〔ａ〕キノリジン誘導体およびその塩

Country Status (1)

Country Link
JP (1) JPS60197684A (e)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014525451A (ja) * 2011-08-29 2014-09-29 ピーティーシー セラピューティクス， インコーポレイテッド 抗菌化合物および使用方法
US20150210682A1 (en) * 2014-01-30 2015-07-30 Hoffmann-La Roche Inc. Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
WO2015173164A1 (en) * 2014-05-13 2015-11-19 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
WO2016071215A1 (en) * 2014-11-03 2016-05-12 F. Hoffmann-La Roche Ag Novel 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis b virus infection
WO2017016960A1 (en) * 2015-07-24 2017-02-02 F. Hoffmann-La Roche Ag Process for the preparation of (6s)-6-alkyl-10-alkoxy-9-(substituted alkoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid analogues
CN106810548A (zh) * 2017-01-13 2017-06-09 上海爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物
CN107207505A (zh) * 2015-02-11 2017-09-26 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的2‑氧代‑6,7‑二氢苯并[a]喹嗪‑3‑甲酸衍生物
US9845322B2 (en) 2015-05-04 2017-12-19 Hoffmann-La Roche Inc. Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection
US10053461B2 (en) 2015-07-27 2018-08-21 Hoffmann-La Roche Inc. Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
JP2018524374A (ja) * 2015-07-21 2018-08-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療および予防のための新規な三環式４−ピリドン−３−カルボン酸誘導体
US10150740B2 (en) 2015-07-28 2018-12-11 Hoffmann-La Roche Inc. 6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection
JP2019523261A (ja) * 2016-07-29 2019-08-22 銀杏樹薬業（蘇州）有限公司 イソキノリノン系化合物及び抗ウイルス剤としての用途
US10821103B2 (en) 2016-11-07 2020-11-03 Arbutus Biopharma Corporation Substituted pyridinone-containing trycyclic compounds, and methods using same
US11505551B2 (en) 2018-04-12 2022-11-22 Arbutus Biopharma Corporation Methods for preparing substituted pyridinone-containing tricyclic compounds
US11702427B2 (en) 2018-03-12 2023-07-18 Arbutus Biopharma Corporation Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014525451A (ja) * 2011-08-29 2014-09-29 ピーティーシー セラピューティクス， インコーポレイテッド 抗菌化合物および使用方法
TWI582094B (zh) * 2014-01-30 2017-05-11 赫孚孟拉羅股份公司 用於治療及預防ｂ型肝炎病毒感染之新穎二氫喹□酮
US20150210682A1 (en) * 2014-01-30 2015-07-30 Hoffmann-La Roche Inc. Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
US9949966B2 (en) * 2014-01-30 2018-04-24 Hoffman-La Roche Inc. Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
CN105899508A (zh) * 2014-01-30 2016-08-24 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新型二氢喹嗪酮类化合物
US9458153B2 (en) 2014-01-30 2016-10-04 Hoffmann-La Roche Inc. Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
US20160296515A1 (en) * 2014-01-30 2016-10-13 Hoffmann-La Roche Inc. Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
CN105899508B (zh) * 2014-01-30 2017-07-04 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新型二氢喹嗪酮类化合物
JP2017504633A (ja) * 2014-01-30 2017-02-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染の治療及び予防のための新規なジヒドロキノリジノン
US9920049B2 (en) 2014-05-13 2018-03-20 Hoffman-La Roche Inc. Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
CN106459032B (zh) * 2014-05-13 2019-04-05 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的新的二氢喹嗪酮类
JP2017515844A (ja) * 2014-05-13 2017-06-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療及び予防のための新規ジヒドロキノリジノン類
CN106459032A (zh) * 2014-05-13 2017-02-22 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的新的二氢喹嗪酮类
WO2015173164A1 (en) * 2014-05-13 2015-11-19 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
WO2016071215A1 (en) * 2014-11-03 2016-05-12 F. Hoffmann-La Roche Ag Novel 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN107108606B (zh) * 2014-11-03 2018-12-21 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的6,7-二氢苯并[a]喹嗪-2-酮衍生物
CN107108606A (zh) * 2014-11-03 2017-08-29 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的6,7‑二氢苯并[a]喹嗪‑2‑酮衍生物
JP2017537143A (ja) * 2014-11-03 2017-12-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染の治療又は予防用の新規６，７−ジヒドロベンゾ［ａ］キノリジン−２−オン誘導体
US10093671B2 (en) 2015-02-11 2018-10-09 Hoffmann-La Roche Inc. 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
CN107207505A (zh) * 2015-02-11 2017-09-26 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的2‑氧代‑6,7‑二氢苯并[a]喹嗪‑3‑甲酸衍生物
CN107207505B (zh) * 2015-02-11 2018-12-14 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的 2-氧代-6,7-二氢苯并[a]喹嗪-3-甲酸衍生物
US9845322B2 (en) 2015-05-04 2017-12-19 Hoffmann-La Roche Inc. Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection
US10336751B2 (en) 2015-07-21 2019-07-02 Hoffmann-La Roche Inc. Tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
JP2018524374A (ja) * 2015-07-21 2018-08-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療および予防のための新規な三環式４−ピリドン−３−カルボン酸誘導体
WO2017016960A1 (en) * 2015-07-24 2017-02-02 F. Hoffmann-La Roche Ag Process for the preparation of (6s)-6-alkyl-10-alkoxy-9-(substituted alkoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid analogues
US10053461B2 (en) 2015-07-27 2018-08-21 Hoffmann-La Roche Inc. Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
US10150740B2 (en) 2015-07-28 2018-12-11 Hoffmann-La Roche Inc. 6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection
JP2019523261A (ja) * 2016-07-29 2019-08-22 銀杏樹薬業（蘇州）有限公司 イソキノリノン系化合物及び抗ウイルス剤としての用途
US10821103B2 (en) 2016-11-07 2020-11-03 Arbutus Biopharma Corporation Substituted pyridinone-containing trycyclic compounds, and methods using same
US11013726B2 (en) 2016-11-07 2021-05-25 Arbutus Biopharma Corporation Substituted pyridinone-containing trycyclic compounds, and methods using same
CN106810548A (zh) * 2017-01-13 2017-06-09 上海爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物
CN110177785A (zh) * 2017-01-13 2019-08-27 苏州爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物
CN106810548B (zh) * 2017-01-13 2019-02-15 苏州爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物
CN110177785B (zh) * 2017-01-13 2022-02-08 苏州爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物
US11702427B2 (en) 2018-03-12 2023-07-18 Arbutus Biopharma Corporation Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same
US11505551B2 (en) 2018-04-12 2022-11-22 Arbutus Biopharma Corporation Methods for preparing substituted pyridinone-containing tricyclic compounds

Also Published As

Publication number Publication date
JPH0477B2 (e) 1992-01-06

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