JPS60118196A - インタ−フェロンの製造法 - Google Patents

インタ−フェロンの製造法

Info

Publication number
JPS60118196A
JPS60118196A JP58227750A JP22775083A JPS60118196A JP S60118196 A JPS60118196 A JP S60118196A JP 58227750 A JP58227750 A JP 58227750A JP 22775083 A JP22775083 A JP 22775083A JP S60118196 A JPS60118196 A JP S60118196A
Authority
JP
Japan
Prior art keywords
medium
interferon
gene
ion source
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58227750A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0515435B2 (enExample
Inventor
Kazuaki Kitano
北野　一昭
Shigeru Fujimoto
茂 藤本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP58227750A priority Critical patent/JPS60118196A/ja
Priority to US06/674,598 priority patent/US4656131A/en
Priority to EP84114368A priority patent/EP0144064B1/en
Priority to AT84114368T priority patent/ATE44047T1/de
Priority to DE8484114368T priority patent/DE3478699D1/de
Priority to KR1019840007522A priority patent/KR920006868B1/ko
Priority to CA000468911A priority patent/CA1256814A/en
Priority to CN 85102303 priority patent/CN1014903B/zh
Publication of JPS60118196A publication Critical patent/JPS60118196A/ja
Publication of JPH0515435B2 publication Critical patent/JPH0515435B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP58227750A 1983-11-30 1983-11-30 インタ−フェロンの製造法 Granted JPS60118196A (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP58227750A JPS60118196A (ja) 1983-11-30 1983-11-30 インタ−フェロンの製造法
US06/674,598 US4656131A (en) 1983-11-30 1984-11-26 Method for producing interferons
EP84114368A EP0144064B1 (en) 1983-11-30 1984-11-28 Method for producing interferons
AT84114368T ATE44047T1 (de) 1983-11-30 1984-11-28 Verfahren zur herstellung von interferonen.
DE8484114368T DE3478699D1 (en) 1983-11-30 1984-11-28 Method for producing interferons
KR1019840007522A KR920006868B1 (ko) 1983-11-30 1984-11-29 인터페론의 제조방법
CA000468911A CA1256814A (en) 1983-11-30 1984-11-29 Method for producing interferons
CN 85102303 CN1014903B (zh) 1983-11-30 1985-04-01 生产干扰素的方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58227750A JPS60118196A (ja) 1983-11-30 1983-11-30 インタ−フェロンの製造法

Publications (2)

Publication Number Publication Date
JPS60118196A true JPS60118196A (ja) 1985-06-25
JPH0515435B2 JPH0515435B2 (enExample) 1993-03-01

Family

ID=16865782

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58227750A Granted JPS60118196A (ja) 1983-11-30 1983-11-30 インタ−フェロンの製造法

Country Status (7)

Country Link
US (1) US4656131A (enExample)
EP (1) EP0144064B1 (enExample)
JP (1) JPS60118196A (enExample)
KR (1) KR920006868B1 (enExample)
AT (1) ATE44047T1 (enExample)
CA (1) CA1256814A (enExample)
DE (1) DE3478699D1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519909A (ja) * 2007-03-02 2010-06-10 ワイス エルエルシー ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855238A (en) 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
FI90990C (fi) * 1984-12-18 1994-04-25 Boehringer Ingelheim Int Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi
US5523215A (en) * 1985-03-28 1996-06-04 Chiron Corporation Enhanced purification and expression of insoluble recombinant proteins
EP0200417B1 (en) * 1985-04-30 1992-10-21 Takeda Chemical Industries, Ltd. Production of protein
DE3532134A1 (de) * 1985-09-10 1987-03-12 Basf Ag Verfahren zur herstellung von proteinen bestimmter n-terminaler struktur mit hilfe von prokaryonten
US5210029A (en) * 1985-10-03 1993-05-11 Takeda Chemical Industries, Ltd. Method of producing interleukin-2
DE3642096A1 (de) * 1986-12-10 1988-06-16 Boehringer Ingelheim Int Pferde-(gamma)-interferon
US5177011A (en) * 1988-08-18 1993-01-05 Calgene, Inc. Plant elongation factor promoters, coding sequences and uses
AU4210389A (en) * 1988-08-18 1990-03-23 Calgene, Inc. Plant elongation factor, promoters, coding sequences and uses
US5508192A (en) * 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US5264365A (en) * 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
ATE195142T1 (de) * 1991-02-26 2000-08-15 Zeneca Ltd Fermentationsverfahren zur herstellung von peptiden durch einen wirt
EP0625991B1 (en) * 1992-02-10 1999-04-28 Interferon Sciences, Inc. Improved alpha interferon composition and method for its production from human peripheral blood leukocytes
US5676942A (en) * 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof
US5487986A (en) * 1994-03-10 1996-01-30 Genzyme Corporation Method for increasing plasmid yield
US5814485A (en) * 1995-06-06 1998-09-29 Chiron Corporation Production of interferon-β (IFN-β) in E. coli
US20030108997A1 (en) * 2001-09-20 2003-06-12 Mahr Klaus Di. Optimizing temperature shifting in high cell density fermentations
JP4149253B2 (ja) * 2002-12-17 2008-09-10 忠行 今中 微生物の低温培養方法
RU2631001C2 (ru) * 2010-08-30 2017-09-15 Ф.Хоффманн-Ля Рош Аг Способ получения полипептида

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065156A (en) * 1961-08-29 1962-11-20 Organon Electrolytic ph regulator
JPS57194787A (en) * 1981-05-28 1982-11-30 Ajinomoto Co Inc Culture medium for animal cell
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
US4450103A (en) * 1982-03-01 1984-05-22 Cetus Corporation Process for recovering human IFN-β from a transformed microorganism
JPS59181224A (ja) * 1983-03-29 1984-10-15 Sumitomo Chem Co Ltd 安定なインタ−フエロン製剤の製法
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519909A (ja) * 2007-03-02 2010-06-10 ワイス エルエルシー ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用

Also Published As

Publication number Publication date
US4656131A (en) 1987-04-07
ATE44047T1 (de) 1989-06-15
EP0144064B1 (en) 1989-06-14
KR850003735A (ko) 1985-06-26
KR920006868B1 (ko) 1992-08-21
CA1256814A (en) 1989-07-04
EP0144064A3 (en) 1986-10-08
DE3478699D1 (en) 1989-07-20
EP0144064A2 (en) 1985-06-12
JPH0515435B2 (enExample) 1993-03-01

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