JPS5980663A - ジヒドロピリジン類 - Google Patents

ジヒドロピリジン類

Info

Publication number
JPS5980663A
JPS5980663A JP58163103A JP16310383A JPS5980663A JP S5980663 A JPS5980663 A JP S5980663A JP 58163103 A JP58163103 A JP 58163103A JP 16310383 A JP16310383 A JP 16310383A JP S5980663 A JPS5980663 A JP S5980663A
Authority
JP
Japan
Prior art keywords
alkyl
aryl
compound
chlorophenyl
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58163103A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6222985B2 (en, 2012
Inventor
サイモン・フレイザ−・キンプベル
ピ−タ−・エドワ−ド・クロス
ジヨン・ケンドリツク・スタツプス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of JPS5980663A publication Critical patent/JPS5980663A/ja
Publication of JPS6222985B2 publication Critical patent/JPS6222985B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Peptides Or Proteins (AREA)
JP58163103A 1982-09-04 1983-09-05 ジヒドロピリジン類 Granted JPS5980663A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8225246 1982-09-04
GB8225246 1982-09-04

Publications (2)

Publication Number Publication Date
JPS5980663A true JPS5980663A (ja) 1984-05-10
JPS6222985B2 JPS6222985B2 (en, 2012) 1987-05-20

Family

ID=10532690

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58163103A Granted JPS5980663A (ja) 1982-09-04 1983-09-05 ジヒドロピリジン類

Country Status (25)

Country Link
US (1) US4539322A (en, 2012)
EP (1) EP0106462B1 (en, 2012)
JP (1) JPS5980663A (en, 2012)
KR (1) KR880000180B1 (en, 2012)
AT (1) ATE39112T1 (en, 2012)
AU (1) AU542454B2 (en, 2012)
CA (1) CA1205470A (en, 2012)
CS (1) CS242881B2 (en, 2012)
DD (1) DD215544A5 (en, 2012)
DE (1) DE3378632D1 (en, 2012)
DK (1) DK161700C (en, 2012)
ES (2) ES8604200A1 (en, 2012)
FI (1) FI80262C (en, 2012)
GR (1) GR78985B (en, 2012)
HU (1) HU191092B (en, 2012)
IE (1) IE55904B1 (en, 2012)
IL (1) IL69627A (en, 2012)
NO (1) NO160259C (en, 2012)
NZ (1) NZ205472A (en, 2012)
PH (1) PH19166A (en, 2012)
PL (2) PL139499B1 (en, 2012)
PT (1) PT77283B (en, 2012)
SU (2) SU1364237A3 (en, 2012)
YU (2) YU43659B (en, 2012)
ZA (1) ZA836514B (en, 2012)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62252762A (ja) * 1986-01-21 1987-11-04 Nippon Shinyaku Co Ltd ピログルタミド誘導体

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
GB8415386D0 (en) * 1984-06-15 1984-07-18 Pfizer Ltd Therapeutic agents
GR851819B (en, 2012) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
GB8421039D0 (en) * 1984-08-17 1984-09-19 Wyeth John & Brother Ltd Heterocyclic compounds
IT1204421B (it) * 1986-06-27 1989-03-01 Boehringer Biochemia Srl 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
GB8527698D0 (en) * 1985-11-09 1985-12-11 Pfizer Ltd Dihydropyridine antiischaemic & antihypertensive agents
DE3621104A1 (de) * 1986-06-24 1988-01-07 Heumann Pharma Gmbh & Co 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
IT1197012B (it) * 1986-07-29 1988-11-25 Boehringer Biochemia Srl 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
US4855001A (en) * 1987-02-10 1989-08-08 Lord Corporation Structural adhesive formulations and bonding method employing same
GB8712747D0 (en) * 1987-05-30 1987-07-01 Pfizer Ltd Therapeutic agents
EP0711554A4 (en) * 1993-07-28 1997-07-23 Nippon Shinyaku Co Ltd ANTIDEPRESSANT
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
US5700801A (en) * 1994-12-23 1997-12-23 Karl Thomae, Gmbh Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
EE9700141A (et) * 1994-12-23 1997-12-15 Dr. Karl Thomae Gmbh Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod
RU2126001C1 (ru) * 1995-01-10 1999-02-10 Самдзин Фармасьютикал Ко., Лтд Производные пиперазина и фармацевтическая композиция на их основе
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
FR2829766A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
WO2022175384A1 (en) * 2021-02-17 2022-08-25 Fundación Universidad Católica De Valencia San Vicente Mártir Small-molecule agents with antiviral activity against rna viruses

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1307256A (en) * 1970-09-15 1973-02-14 Science Union & Cie Piperazine derivatives and a process for their preparation
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3943140A (en) * 1972-09-30 1976-03-09 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2658183A1 (de) * 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4177278A (en) * 1977-04-05 1979-12-04 Bayer Aktiengesellschaft 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
JPS5547656A (en) * 1978-09-29 1980-04-04 Dainippon Pharmaceut Co Ltd 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62252762A (ja) * 1986-01-21 1987-11-04 Nippon Shinyaku Co Ltd ピログルタミド誘導体

Also Published As

Publication number Publication date
CA1205470A (en) 1986-06-03
ES8604200A1 (es) 1986-01-16
KR840006236A (ko) 1984-11-22
YU43659B (en) 1989-10-31
CS242881B2 (en) 1986-05-15
PL139499B1 (en) 1987-01-31
PT77283A (en) 1983-10-01
DK161700C (da) 1992-01-06
ES525241A0 (es) 1986-01-16
DK398383A (da) 1984-03-05
US4539322A (en) 1985-09-03
NO160259B (no) 1988-12-19
EP0106462A3 (en) 1984-05-30
CS639583A2 (en) 1985-08-15
DK161700B (da) 1991-08-05
YU178583A (en) 1986-10-31
IL69627A0 (en) 1983-12-30
AU542454B2 (en) 1985-02-21
SU1378782A3 (ru) 1988-02-28
KR880000180B1 (ko) 1988-03-12
FI80262C (fi) 1990-05-10
DD215544A5 (de) 1984-11-14
AU1865883A (en) 1984-03-08
EP0106462B1 (en) 1988-12-07
FI833117A0 (fi) 1983-09-01
PT77283B (en) 1986-05-19
HU191092B (en) 1987-01-28
PL250618A1 (en) 1985-07-30
IE55904B1 (en) 1991-02-14
GR78985B (en, 2012) 1984-10-02
IL69627A (en) 1986-08-31
ATE39112T1 (de) 1988-12-15
PH19166A (en) 1986-01-16
DE3378632D1 (en) 1989-01-12
ES8602760A1 (es) 1985-12-01
FI80262B (fi) 1990-01-31
NO160259C (no) 1989-03-29
YU43598B (en) 1989-08-31
YU179985A (en) 1986-10-31
JPS6222985B2 (en, 2012) 1987-05-20
EP0106462A2 (en) 1984-04-25
FI833117A7 (fi) 1984-03-05
NZ205472A (en) 1985-08-16
PL243621A1 (en) 1985-05-07
NO833159L (no) 1984-03-05
ZA836514B (en) 1984-07-25
DK398383D0 (da) 1983-09-01
ES532038A0 (es) 1985-12-01
SU1364237A3 (ru) 1987-12-30
IE832058L (en) 1984-03-04
PL143900B1 (en) 1988-03-31

Similar Documents

Publication Publication Date Title
JPS5980663A (ja) ジヒドロピリジン類
US4656181A (en) Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
USRE38257E1 (en) Piperdine derivatives and hypotensives containing the same
US5874447A (en) 4-Phenylpiperidine compounds for treating depression
EP0094159B1 (en) Dihydropyridine derivatives, their production and use
US4430333A (en) Dihydropyridine anti-ischaemic and antihypertensive agents
US4822798A (en) Circulation-active 4-phenyl-6-substituted dihydropyrimidines
JPH0542431B2 (en, 2012)
JPS6025424B2 (ja) １，４‐ジヒドロピリジンカルボン酸アラルキルエステル
US5589486A (en) N-hydroxyalkyl-substituted 1,2,3,6-tetrahydro-pyridine and piperidine derivatives
JPS6185362A (ja) 新規ジアリール化合物
US5001134A (en) Piperidines, processes of preparation and medications containing them
US4894460A (en) Basic esters exhibiting an antagonistic activity to calcium, process for the preparation thereof and pharmaceutical compositions therefrom
DE3512995A1 (de) Dihydropyridinyldicarbonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
JP3058746B2 (ja) 置換ｎ−フェニルピペリジン
US4569933A (en) Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
CA1231950A (fr) Procede d'obtention de nouveaux derives substitues du 2,5-diamino 1,4-diazole et des compositions pharmaceutiques en renfermant
HU208422B (en) Process for producing 1-//diaryl-methoxy/-alkyl/-pyrrolidine- and 1-//diaryl-methoxy/-alkyl/-piperidine derivatives
JPS611685A (ja) ジヒドロピリジン類
CH654837A5 (de) Cyclische dihydropyridylimidatester, verfahren zu ihrer herstellung und pharmazeutische mittel.
KR870001681B1 (ko) 히단토인 유도체의 제조방법
US4547502A (en) Dihydropyridines and their use in treating cardiac conditions and hypertension
US4029790A (en) 1-Benzoyl-2 or 4 [2-(4-phenyl-piperazino)-ethyl]-piperidines
JPS5916876A (ja) カルシウムに拮抗する塩基性エステル、その製造法およびそれを有効成分とする医薬
JPS62501972A (ja) 新規ピペラジン誘導体