PL143900B1 - Method of obtaining new derivatives of dihydropyridine - Google Patents
Method of obtaining new derivatives of dihydropyridine Download PDFInfo
- Publication number
- PL143900B1 PL143900B1 PL1983250618A PL25061883A PL143900B1 PL 143900 B1 PL143900 B1 PL 143900B1 PL 1983250618 A PL1983250618 A PL 1983250618A PL 25061883 A PL25061883 A PL 25061883A PL 143900 B1 PL143900 B1 PL 143900B1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Peptides Or Proteins (AREA)
Claims (3)
1. Zastrzezenia patentowe 1. * Sposób wytwarzania nowych pochodnych dihydropirydyny o ogólnym wzorze 1, w którym R oznacza grupe fenylowa ewentualnie podstawiona 1 lub 2 podstawnikami, takimi Jak atom 1 2 chlorowca lub grupa trój fiuorometylowa, grupe naftylowa lub grupe tiazolilowa, R i R sa Jednakowe lub rózne 1 oznaczaja grupe C2-C4-alkilowa lub 2-metoksyetylowa, a Y oznacza grupe -/CH2/2-, -/CHg/^-, -CHgCH/CILj/- lub -CHgC/CILj/g-, oraz farmakologicznie dopuszczal¬ nych soli addycyjnych tych zwiazków z kwasami, znamienny tym, ze ze zwiazku o 1 2 ogólnym wzorze 2, w którym R, R , R i Y maja wyzej podane znaczenie, a Q oznacza grupe zabezpieczajaca, taka Jak grupa benzylowa, 4-chlorobenzylowa lub tritylowa, odszczepla sie te grupe zabezpieczajaca, po czym powstaly zwiazek o wzorze 1 ewentualnie przeprowadza sie w farmakologicznie dopuszczalna sól dzialajac odpowiednim kwasem*
2. * Sposób wedlug zastrz*l, znamienny tym, ze w przypadku gdy Q oznacza grupe benzylowa lub 4-chlorobenzylowa, to wówczas te grupy odszczepla sie przez uwodornie¬ nie, a w przypadku gdy Q oznacza grupe tritylowa, to odszczepla sie ja za pomoca kwasu*
3. * Sposób wedlug zastrz*l, znamienny t y m, ze jako substrat stosuje sie zwiazek o wzorze 2, w którym R oznacza grupe 2-chlorofenylowa, 2-trójfluorometylofenylowa, 2,3-dwuchlorofetiylowa, 3,5-dwuchlorofenylowa, 2,6-dwuchlorofenylowa, i-naftylowa, 3-chlo- 1 2 rofenylowa lub 2-fluorofenylowa, R oznacza CLU, a R oznacza C2H5*113 900 C^CHjN NCaCHjOCHjCC^CCaCjHs + RCHO + CH3 i etanol, lodowaty kwas octowy, i ogrzewanie C-CHCOOCH, I 3 NH2 H R C^OOCs^^COOCjHs CH3-^N ^CHjOCHjCHjN^^NCHjCjHj; H Schemat 5 CH3OOC H C u CH3 NH2 CHO + I + /COOC2H5 CH2 o' ^HjOCHjCHjN^-CfCeHs), H^ CHaOOC^YCOOCjHj CH3ANJLcH2OCH2CH2N WcjLU H w HCl H. CH3OOC y^Ycooc2h5 CH3^N ^CHjOCHjCHjN^^NH H \_v Schemat 6143 900 CH300Cy CH3^N ^^OC^CHjN^^N-CHj ZwiazekC r CO Z CH300CV~YCOOCH,CH, CH3^ N ^^CHjOCHjCHjN NH H Zwiazek B Schemat 1 CH3C0C=CH -f + C02CH3 CH COOCjHj _ avjaz6kc C NH^ XCH20(CH2)2-N^^N-CH2H^-Z Schemat 2 CH300Cnj^Y(XX)CH2CH3 H2/Pd/Cr H R CH300C y^COOCH^ CH3 N^ CH20Y-~f/^NH Schemat 3 Cl CH2C CH2CO2C2H5 + H0CH2CH2Nv_Jl-CH2C6H5 6 NaH/THF O C6H5CH2N ^NCHjCHjOCHjC^CC^CjHs Schemat 4143 900 H R R^OOCy^COOR2 HjC^N^^OL-O-Y-N^^NH WzóM H R tfOOCYY0001*2 CH,^ N "^ CH2 OYN^~\-Q Wzór 2 R'OOC H C CH3 NH2 Wzór 3 R R1OOC yCH r CH3 0 Wzór 5 /COOR2 CH2 1 c o' XCH2OYN NQ Wzór** COOR2 CH A ^ NH2 CH2OYN NQ Wzór6 N ' Wzór! Cl^^Cl CF3 Wzór8 Wzór 10 Wzór 11 Cl Cl Wzór 9 Cl Wzór 12 :Xc CHaOOCY^YCOOCjHj ch3An ^ch2och2ch2 n; ,nh H r~\ Wzór 13 N^S Wzór 14 Wzór 15 PL PL PL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8225246 | 1982-09-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL250618A1 PL250618A1 (en) | 1985-07-30 |
| PL143900B1 true PL143900B1 (en) | 1988-03-31 |
Family
ID=10532690
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1983243621A PL139499B1 (en) | 1982-09-04 | 1983-09-02 | Method of obtaining new derivatives of dihydropyridine |
| PL1983250618A PL143900B1 (en) | 1982-09-04 | 1983-09-02 | Method of obtaining new derivatives of dihydropyridine |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1983243621A PL139499B1 (en) | 1982-09-04 | 1983-09-02 | Method of obtaining new derivatives of dihydropyridine |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4539322A (pl) |
| EP (1) | EP0106462B1 (pl) |
| JP (1) | JPS5980663A (pl) |
| KR (1) | KR880000180B1 (pl) |
| AT (1) | ATE39112T1 (pl) |
| AU (1) | AU542454B2 (pl) |
| CA (1) | CA1205470A (pl) |
| CS (1) | CS242881B2 (pl) |
| DD (1) | DD215544A5 (pl) |
| DE (1) | DE3378632D1 (pl) |
| DK (1) | DK161700C (pl) |
| ES (2) | ES8604200A1 (pl) |
| FI (1) | FI80262C (pl) |
| GR (1) | GR78985B (pl) |
| HU (1) | HU191092B (pl) |
| IE (1) | IE55904B1 (pl) |
| IL (1) | IL69627A (pl) |
| NO (1) | NO160259C (pl) |
| NZ (1) | NZ205472A (pl) |
| PH (1) | PH19166A (pl) |
| PL (2) | PL139499B1 (pl) |
| PT (1) | PT77283B (pl) |
| SU (2) | SU1364237A3 (pl) |
| YU (2) | YU43659B (pl) |
| ZA (1) | ZA836514B (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568677A (en) * | 1983-07-23 | 1986-02-04 | Pfizer Inc. | 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents |
| GB8415386D0 (en) * | 1984-06-15 | 1984-07-18 | Pfizer Ltd | Therapeutic agents |
| GB8421039D0 (en) * | 1984-08-17 | 1984-09-19 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| GR851819B (pl) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
| IT1204421B (it) * | 1986-06-27 | 1989-03-01 | Boehringer Biochemia Srl | 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono |
| GB8527698D0 (en) * | 1985-11-09 | 1985-12-11 | Pfizer Ltd | Dihydropyridine antiischaemic & antihypertensive agents |
| JP2513197B2 (ja) * | 1986-01-21 | 1996-07-03 | 日本新薬株式会社 | ピログルタミド誘導体 |
| DE3621104A1 (de) * | 1986-06-24 | 1988-01-07 | Heumann Pharma Gmbh & Co | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| IT1197012B (it) * | 1986-07-29 | 1988-11-25 | Boehringer Biochemia Srl | 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
| US4855001A (en) * | 1987-02-10 | 1989-08-08 | Lord Corporation | Structural adhesive formulations and bonding method employing same |
| GB8712747D0 (en) * | 1987-05-30 | 1987-07-01 | Pfizer Ltd | Therapeutic agents |
| CA2168265C (en) * | 1993-07-28 | 1999-02-23 | Kiyoshi Kimura | Antidepressant |
| DE4410822A1 (de) * | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
| EE9700141A (et) * | 1994-12-23 | 1997-12-15 | Dr. Karl Thomae Gmbh | Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod |
| US5700801A (en) * | 1994-12-23 | 1997-12-23 | Karl Thomae, Gmbh | Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| US6756389B2 (en) * | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
| WO2022175384A1 (en) * | 2021-02-17 | 2022-08-25 | Fundación Universidad Católica De Valencia San Vicente Mártir | Small-molecule agents with antiviral activity against rna viruses |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1307256A (en) * | 1970-09-15 | 1973-02-14 | Science Union & Cie | Piperazine derivatives and a process for their preparation |
| DE2218644C3 (de) * | 1972-04-18 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2248150A1 (de) * | 1972-09-30 | 1974-04-04 | Bayer Ag | Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US3946027A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
| US3946028A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
| US3943140A (en) * | 1972-09-30 | 1976-03-09 | Bayer Aktiengesellschaft | 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives |
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
| DE2658183A1 (de) * | 1976-12-22 | 1978-07-06 | Bayer Ag | In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4177278A (en) * | 1977-04-05 | 1979-12-04 | Bayer Aktiengesellschaft | 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use |
| US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
| JPS5547656A (en) * | 1978-09-29 | 1980-04-04 | Dainippon Pharmaceut Co Ltd | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
| SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
-
1983
- 1983-08-24 PH PH29436A patent/PH19166A/en unknown
- 1983-08-26 AT AT83304954T patent/ATE39112T1/de not_active IP Right Cessation
- 1983-08-26 DE DE8383304954T patent/DE3378632D1/de not_active Expired
- 1983-08-26 EP EP83304954A patent/EP0106462B1/en not_active Expired
- 1983-08-30 ES ES525241A patent/ES8604200A1/es not_active Expired
- 1983-09-01 FI FI833117A patent/FI80262C/fi not_active IP Right Cessation
- 1983-09-01 DK DK398383A patent/DK161700C/da not_active IP Right Cessation
- 1983-09-01 YU YU1785/83A patent/YU43659B/xx unknown
- 1983-09-01 IE IE2058/83A patent/IE55904B1/en not_active IP Right Cessation
- 1983-09-01 US US06/528,507 patent/US4539322A/en not_active Expired - Fee Related
- 1983-09-02 DD DD83254486A patent/DD215544A5/de not_active IP Right Cessation
- 1983-09-02 AU AU18658/83A patent/AU542454B2/en not_active Ceased
- 1983-09-02 GR GR72365A patent/GR78985B/el unknown
- 1983-09-02 IL IL69627A patent/IL69627A/xx not_active IP Right Cessation
- 1983-09-02 NZ NZ205472A patent/NZ205472A/en unknown
- 1983-09-02 HU HU833077A patent/HU191092B/hu not_active IP Right Cessation
- 1983-09-02 NO NO833159A patent/NO160259C/no unknown
- 1983-09-02 CS CS836395A patent/CS242881B2/cs unknown
- 1983-09-02 PL PL1983243621A patent/PL139499B1/pl unknown
- 1983-09-02 PL PL1983250618A patent/PL143900B1/pl unknown
- 1983-09-02 CA CA000435935A patent/CA1205470A/en not_active Expired
- 1983-09-02 ZA ZA836514A patent/ZA836514B/xx unknown
- 1983-09-02 SU SU833641411A patent/SU1364237A3/ru active
- 1983-09-02 PT PT77283A patent/PT77283B/pt not_active IP Right Cessation
- 1983-09-03 KR KR1019830004157A patent/KR880000180B1/ko not_active IP Right Cessation
- 1983-09-05 JP JP58163103A patent/JPS5980663A/ja active Granted
-
1984
- 1984-04-30 ES ES532038A patent/ES532038A0/es active Granted
- 1984-06-11 SU SU843750492A patent/SU1378782A3/ru active
-
1985
- 1985-11-19 YU YU1799/85A patent/YU43598B/xx unknown
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