JPS59172417A - リボフラビン酪酸エステル含有軟カプセル - Google Patents
リボフラビン酪酸エステル含有軟カプセルInfo
- Publication number
- JPS59172417A JPS59172417A JP4710983A JP4710983A JPS59172417A JP S59172417 A JPS59172417 A JP S59172417A JP 4710983 A JP4710983 A JP 4710983A JP 4710983 A JP4710983 A JP 4710983A JP S59172417 A JPS59172417 A JP S59172417A
- Authority
- JP
- Japan
- Prior art keywords
- riboflavin butyrate
- forming agent
- film
- pigment
- tocopherol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 22
- MJNIWUJSIGSWKK-BBANNHEPSA-N Riboflavin butyrate Chemical compound CCCC(=O)OC[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)CN1C2=CC(C)=C(C)C=C2N=C2C1=NC(=O)NC2=O MJNIWUJSIGSWKK-BBANNHEPSA-N 0.000 title claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 16
- 239000011732 tocopherol Substances 0.000 claims abstract description 13
- 229930003799 tocopherol Natural products 0.000 claims abstract description 13
- 239000000049 pigment Substances 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 4
- 235000019149 tocopherols Nutrition 0.000 claims description 7
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract description 7
- 235000010384 tocopherol Nutrition 0.000 abstract description 6
- 229960001295 tocopherol Drugs 0.000 abstract description 6
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract description 5
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 abstract description 4
- -1 tocopherol compound Chemical class 0.000 abstract description 3
- 206010003210 Arteriosclerosis Diseases 0.000 abstract description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 abstract description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract description 2
- 235000013734 beta-carotene Nutrition 0.000 abstract description 2
- 239000011648 beta-carotene Substances 0.000 abstract description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 abstract description 2
- 229960002747 betacarotene Drugs 0.000 abstract description 2
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 238000000354 decomposition reaction Methods 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 210000005259 peripheral blood Anatomy 0.000 abstract description 2
- 239000011886 peripheral blood Substances 0.000 abstract description 2
- 238000007540 photo-reduction reaction Methods 0.000 abstract description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 235000012756 tartrazine Nutrition 0.000 abstract 1
- 239000004149 tartrazine Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229960000984 tocofersolan Drugs 0.000 description 3
- 239000002076 α-tocopherol Substances 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 229940087168 alpha tocopherol Drugs 0.000 description 2
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 description 1
- SEBIKDIMAPSUBY-JAUCNNNOSA-N Crocin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C=CC=C(/C)C(=O)OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O SEBIKDIMAPSUBY-JAUCNNNOSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 244000111489 Gardenia augusta Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002168 ethanoic acid esters Chemical class 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- KINGXFAMZNIVNL-SXQDSXCISA-N safflor yellow A Natural products OC[C@@H]1O[C@H]2[C@H](OC3=C2C(=O)C(=C(O)C=Cc4ccc(O)cc4)C(=O)[C@]3(O)[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H]1O KINGXFAMZNIVNL-SXQDSXCISA-N 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4710983A JPS59172417A (ja) | 1983-03-23 | 1983-03-23 | リボフラビン酪酸エステル含有軟カプセル |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4710983A JPS59172417A (ja) | 1983-03-23 | 1983-03-23 | リボフラビン酪酸エステル含有軟カプセル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59172417A true JPS59172417A (ja) | 1984-09-29 |
| JPH0237890B2 JPH0237890B2 (enrdf_load_stackoverflow) | 1990-08-28 |
Family
ID=12766008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4710983A Granted JPS59172417A (ja) | 1983-03-23 | 1983-03-23 | リボフラビン酪酸エステル含有軟カプセル |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59172417A (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6187620A (ja) * | 1984-10-05 | 1986-05-06 | Nisshin Kagaku Kk | ビタミンｂ↓２酪酸エステルソフトカプセル用透明配合薬剤 |
| JPS6425715A (en) * | 1987-04-13 | 1989-01-27 | Ono Pharmaceutical Co | Novel pharmaceutical containing esters or amides as active ingredient |
| JPH04193825A (ja) * | 1990-11-26 | 1992-07-13 | Nippon Eranko Kk | 硬質ゼラチンカプセル |
| WO2000050029A1 (fr) * | 1999-02-23 | 2000-08-31 | Chugai Seiyaku Kabushiki Kaisha | Preparations de capsules molles jonctionnees contenant des derives dihydrobenzofuranes |
| WO2002013819A1 (fr) * | 2000-08-16 | 2002-02-21 | Chugai Seiyaku Kabushiki Kaisha | Preparations pour capsules molles sans raccord contenant des derives de dihydrobenzofuranne |
| FR2837670A1 (fr) * | 2002-03-26 | 2003-10-03 | Longechaud Veronique Fernandez | Capsules en gelatine contenant de l'huil de son riz pure ou enrichie de toute composition chimique ou naturelle a usage de complement nutritionnel |
| US7713523B2 (en) | 2003-09-29 | 2010-05-11 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 and carnitine |
| US8506995B2 (en) * | 1999-03-29 | 2013-08-13 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
| US10166193B2 (en) | 2003-09-29 | 2019-01-01 | Soft Gel Technologies, Inc. | Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene |
| US10314793B2 (en) | 2003-09-29 | 2019-06-11 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
-
1983
- 1983-03-23 JP JP4710983A patent/JPS59172417A/ja active Granted
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6187620A (ja) * | 1984-10-05 | 1986-05-06 | Nisshin Kagaku Kk | ビタミンｂ↓２酪酸エステルソフトカプセル用透明配合薬剤 |
| JPS6425715A (en) * | 1987-04-13 | 1989-01-27 | Ono Pharmaceutical Co | Novel pharmaceutical containing esters or amides as active ingredient |
| JPH04193825A (ja) * | 1990-11-26 | 1992-07-13 | Nippon Eranko Kk | 硬質ゼラチンカプセル |
| WO2000050029A1 (fr) * | 1999-02-23 | 2000-08-31 | Chugai Seiyaku Kabushiki Kaisha | Preparations de capsules molles jonctionnees contenant des derives dihydrobenzofuranes |
| US8506995B2 (en) * | 1999-03-29 | 2013-08-13 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
| WO2002013819A1 (fr) * | 2000-08-16 | 2002-02-21 | Chugai Seiyaku Kabushiki Kaisha | Preparations pour capsules molles sans raccord contenant des derives de dihydrobenzofuranne |
| FR2837670A1 (fr) * | 2002-03-26 | 2003-10-03 | Longechaud Veronique Fernandez | Capsules en gelatine contenant de l'huil de son riz pure ou enrichie de toute composition chimique ou naturelle a usage de complement nutritionnel |
| US7713523B2 (en) | 2003-09-29 | 2010-05-11 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 and carnitine |
| US10166193B2 (en) | 2003-09-29 | 2019-01-01 | Soft Gel Technologies, Inc. | Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene |
| US10166192B2 (en) | 2003-09-29 | 2019-01-01 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| US10314793B2 (en) | 2003-09-29 | 2019-06-11 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0237890B2 (enrdf_load_stackoverflow) | 1990-08-28 |
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