JPS59128390A - セフアロスポリン誘導体及び該誘導体を含有する薬剤 - Google Patents
セフアロスポリン誘導体及び該誘導体を含有する薬剤Info
- Publication number
- JPS59128390A JPS59128390A JP23455382A JP23455382A JPS59128390A JP S59128390 A JPS59128390 A JP S59128390A JP 23455382 A JP23455382 A JP 23455382A JP 23455382 A JP23455382 A JP 23455382A JP S59128390 A JPS59128390 A JP S59128390A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- substance
- cephalosporin
- derivative
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000000034 method Methods 0.000 abstract description 5
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- 125000000217 alkyl group Chemical group 0.000 abstract description 2
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- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- XTKVNQKOTKPCKM-UHFFFAOYSA-N methyl hippurate Chemical compound COC(=O)CNC(=O)C1=CC=CC=C1 XTKVNQKOTKPCKM-UHFFFAOYSA-N 0.000 description 1
- 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- QAXZWHGWYSJAEI-UHFFFAOYSA-N n,n-dimethylformamide;ethanol Chemical compound CCO.CN(C)C=O QAXZWHGWYSJAEI-UHFFFAOYSA-N 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- RNVCVTLRINQCPJ-UHFFFAOYSA-N o-toluidine Chemical compound CC1=CC=CC=C1N RNVCVTLRINQCPJ-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical class O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000004992 toluidines Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23455382A JPS59128390A (ja) | 1982-12-29 | 1982-12-29 | セフアロスポリン誘導体及び該誘導体を含有する薬剤 |
| DE8383307940T DE3379404D1 (en) | 1982-12-29 | 1983-12-23 | Cephalosporin derivatives |
| EP83307940A EP0113245B1 (en) | 1982-12-29 | 1983-12-23 | Cephalosporin derivatives |
| CA000444436A CA1254884A (en) | 1982-12-29 | 1983-12-29 | Derivatives of substituted cephalosporanic acid and antibiotics comprising the same |
| US06/864,574 US4758558A (en) | 1982-12-29 | 1986-05-19 | N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives having antibiotic utility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23455382A JPS59128390A (ja) | 1982-12-29 | 1982-12-29 | セフアロスポリン誘導体及び該誘導体を含有する薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59128390A true JPS59128390A (ja) | 1984-07-24 |
| JPH021836B2 JPH021836B2 (enrdf_load_stackoverflow) | 1990-01-12 |
Family
ID=16972822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP23455382A Granted JPS59128390A (ja) | 1982-12-29 | 1982-12-29 | セフアロスポリン誘導体及び該誘導体を含有する薬剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59128390A (enrdf_load_stackoverflow) |
-
1982
- 1982-12-29 JP JP23455382A patent/JPS59128390A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH021836B2 (enrdf_load_stackoverflow) | 1990-01-12 |
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