JPS591279B2 - 新規ヘレブリゲニンアシル誘導体、その製法及び該誘導体を含有する陽性走心筋作用医薬 - Google Patents

新規ヘレブリゲニンアシル誘導体、その製法及び該誘導体を含有する陽性走心筋作用医薬

Info

Publication number
JPS591279B2
JPS591279B2 JP52152295A JP15229577A JPS591279B2 JP S591279 B2 JPS591279 B2 JP S591279B2 JP 52152295 A JP52152295 A JP 52152295A JP 15229577 A JP15229577 A JP 15229577A JP S591279 B2 JPS591279 B2 JP S591279B2
Authority
JP
Japan
Prior art keywords
group
formula
substituted
alkyl
hellebrigenin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52152295A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5395956A (en
Inventor
オツト−・イザ−ク
クラウス・ポツセルト
ホルスト・ウ−テマン
クラウス・テイ−マ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Publication of JPS5395956A publication Critical patent/JPS5395956A/ja
Publication of JPS591279B2 publication Critical patent/JPS591279B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP52152295A 1976-12-17 1977-12-16 新規ヘレブリゲニンアシル誘導体、その製法及び該誘導体を含有する陽性走心筋作用医薬 Expired JPS591279B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB52759/76A GB1577633A (en) 1976-12-17 1976-12-17 Acyl derivatives of hellebrigenin
GB000052759/76 1976-12-17

Publications (2)

Publication Number Publication Date
JPS5395956A JPS5395956A (en) 1978-08-22
JPS591279B2 true JPS591279B2 (ja) 1984-01-11

Family

ID=10465185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52152295A Expired JPS591279B2 (ja) 1976-12-17 1977-12-16 新規ヘレブリゲニンアシル誘導体、その製法及び該誘導体を含有する陽性走心筋作用医薬

Country Status (15)

Country Link
JP (1) JPS591279B2 (xx)
AT (1) AT372391B (xx)
BE (1) BE861968A (xx)
CH (1) CH639107A5 (xx)
DD (1) DD133151A5 (xx)
DE (1) DE2755122C2 (xx)
ES (2) ES465135A1 (xx)
FI (1) FI58135C (xx)
FR (1) FR2374336A1 (xx)
GB (1) GB1577633A (xx)
HU (1) HU176767B (xx)
IT (1) IT1113251B (xx)
PL (1) PL110178B1 (xx)
SU (2) SU751328A3 (xx)
ZA (1) ZA777494B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61158784U (xx) * 1985-03-25 1986-10-01

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1108702A1 (en) * 1999-12-13 2001-06-20 Kvaerner Process Technology Limited Process for the co-production of aliphatic diols and cyclic ethers
WO2010102673A1 (en) * 2009-03-13 2010-09-16 Unibioscreen S.A. Hellebrin and hellebrigenin derivatives
SG10201503290TA (en) * 2010-04-27 2015-06-29 Pharma Mar Sa Anticancer steroidal lactones unsaturated in position 7 (8)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1901484A1 (de) * 1969-01-14 1970-10-29 Hoechst Ag Herzwirksame Oxyester von Steroid-Cardenoliden und -Bufandienoliden und Verfahren zu ihrer Herstellung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61158784U (xx) * 1985-03-25 1986-10-01

Also Published As

Publication number Publication date
ZA777494B (en) 1979-02-28
DE2755122A1 (de) 1978-06-22
FI773814A (fi) 1978-06-18
AT372391B (de) 1983-09-26
IT1113251B (it) 1986-01-20
ES465135A1 (es) 1978-10-01
DE2755122C2 (de) 1983-06-30
DD133151A5 (de) 1978-12-13
ATA903877A (de) 1983-02-15
CH639107A5 (de) 1983-10-31
JPS5395956A (en) 1978-08-22
SU795487A3 (ru) 1981-01-07
FR2374336B1 (xx) 1980-11-07
ES465136A1 (es) 1979-01-01
FI58135B (fi) 1980-08-29
SU751328A3 (ru) 1980-07-23
BE861968A (fr) 1978-06-16
PL110178B1 (en) 1980-07-31
FI58135C (fi) 1980-12-10
PL203030A1 (pl) 1979-03-26
HU176767B (en) 1981-05-28
FR2374336A1 (fr) 1978-07-13
GB1577633A (en) 1980-10-29

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