ES465135A1 - Procedimiento para la preparacion de nuevos derivados de he-lebrigenina. - Google Patents

Procedimiento para la preparacion de nuevos derivados de he-lebrigenina.

Info

Publication number
ES465135A1
ES465135A1 ES465135A ES465135A ES465135A1 ES 465135 A1 ES465135 A1 ES 465135A1 ES 465135 A ES465135 A ES 465135A ES 465135 A ES465135 A ES 465135A ES 465135 A1 ES465135 A1 ES 465135A1
Authority
ES
Spain
Prior art keywords
radical
substituted
hellebrigenin
alkoxyalkoxy
acyl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465135A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of ES465135A1 publication Critical patent/ES465135A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento para la preparación de nuevos derivados de helerigenina de la fórmula general***(Ver fórmula)en la que R es un radical alquenilo C2-C6un radical halogenoalcohilo-C1-C6un radical cicloalcohilo-C3-C6un radical alcohilo-C3-C18un radical alcohilo-C3-C10 sustituido con un grupo carbalcoxi-C2-C5 o con un grupo carboxies un radical alcoxialcohilo-C2-C6un radical alcoxialcohilo-C2-C6 sustituido con un grupo carboxies un radical feniloun radical fenilo sustituido con grupos nitro.
ES465135A 1976-12-17 1977-12-16 Procedimiento para la preparacion de nuevos derivados de he-lebrigenina. Expired ES465135A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52759/76A GB1577633A (en) 1976-12-17 1976-12-17 Acyl derivatives of hellebrigenin

Publications (1)

Publication Number Publication Date
ES465135A1 true ES465135A1 (es) 1978-10-01

Family

ID=10465185

Family Applications (2)

Application Number Title Priority Date Filing Date
ES465135A Expired ES465135A1 (es) 1976-12-17 1977-12-16 Procedimiento para la preparacion de nuevos derivados de he-lebrigenina.
ES465136A Expired ES465136A1 (es) 1976-12-17 1977-12-16 Procedimiento para la preparacion de nuevos derivados de he-lebrigenina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES465136A Expired ES465136A1 (es) 1976-12-17 1977-12-16 Procedimiento para la preparacion de nuevos derivados de he-lebrigenina

Country Status (15)

Country Link
JP (1) JPS591279B2 (es)
AT (1) AT372391B (es)
BE (1) BE861968A (es)
CH (1) CH639107A5 (es)
DD (1) DD133151A5 (es)
DE (1) DE2755122C2 (es)
ES (2) ES465135A1 (es)
FI (1) FI58135C (es)
FR (1) FR2374336A1 (es)
GB (1) GB1577633A (es)
HU (1) HU176767B (es)
IT (1) IT1113251B (es)
PL (1) PL110178B1 (es)
SU (2) SU751328A3 (es)
ZA (1) ZA777494B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61158784U (es) * 1985-03-25 1986-10-01
EP1108702A1 (en) * 1999-12-13 2001-06-20 Kvaerner Process Technology Limited Process for the co-production of aliphatic diols and cyclic ethers
WO2010102673A1 (en) * 2009-03-13 2010-09-16 Unibioscreen S.A. Hellebrin and hellebrigenin derivatives
SG10201503290TA (en) * 2010-04-27 2015-06-29 Pharma Mar Sa Anticancer steroidal lactones unsaturated in position 7 (8)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1901484A1 (de) * 1969-01-14 1970-10-29 Hoechst Ag Herzwirksame Oxyester von Steroid-Cardenoliden und -Bufandienoliden und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
ZA777494B (en) 1979-02-28
DE2755122A1 (de) 1978-06-22
FI773814A (fi) 1978-06-18
AT372391B (de) 1983-09-26
IT1113251B (it) 1986-01-20
DE2755122C2 (de) 1983-06-30
DD133151A5 (de) 1978-12-13
ATA903877A (de) 1983-02-15
CH639107A5 (de) 1983-10-31
JPS5395956A (en) 1978-08-22
SU795487A3 (ru) 1981-01-07
JPS591279B2 (ja) 1984-01-11
FR2374336B1 (es) 1980-11-07
ES465136A1 (es) 1979-01-01
FI58135B (fi) 1980-08-29
SU751328A3 (ru) 1980-07-23
BE861968A (fr) 1978-06-16
PL110178B1 (en) 1980-07-31
FI58135C (fi) 1980-12-10
PL203030A1 (pl) 1979-03-26
HU176767B (en) 1981-05-28
FR2374336A1 (fr) 1978-07-13
GB1577633A (en) 1980-10-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991220