JPS5877823A - 酵母ｂ型肝炎表面抗原粒子及びワクチン - Google Patents

酵母ｂ型肝炎表面抗原粒子及びワクチン

Info

Publication number
JPS5877823A
JPS5877823A JP57135279A JP13527982A JPS5877823A JP S5877823 A JPS5877823 A JP S5877823A JP 57135279 A JP57135279 A JP 57135279A JP 13527982 A JP13527982 A JP 13527982A JP S5877823 A JPS5877823 A JP S5877823A
Authority
JP
Japan
Prior art keywords
yeast
dna
hbsag
antigen
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57135279A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0526798B2 (enExample
Inventor
ウイリアム・ジエ−・ラツタ−
パブロ・デ−・テ−・ヴアレンツエラ
ベンジヤミン・デ−・ホ−ル
グスタヴ・アムメ−ラ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
University of California
University of California Berkeley
Original Assignee
University of Washington
University of California
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23113710&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5877823(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Washington, University of California, University of California Berkeley filed Critical University of Washington
Publication of JPS5877823A publication Critical patent/JPS5877823A/ja
Publication of JPH0526798B2 publication Critical patent/JPH0526798B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP57135279A 1981-08-04 1982-08-04 酵母ｂ型肝炎表面抗原粒子及びワクチン Granted JPS5877823A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28991581A 1981-08-04 1981-08-04
US289915 1981-08-04

Publications (2)

Publication Number Publication Date
JPS5877823A true JPS5877823A (ja) 1983-05-11
JPH0526798B2 JPH0526798B2 (enExample) 1993-04-19

Family

ID=23113710

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57135279A Granted JPS5877823A (ja) 1981-08-04 1982-08-04 酵母ｂ型肝炎表面抗原粒子及びワクチン

Country Status (12)

Country Link
EP (1) EP0072318B1 (enExample)
JP (1) JPS5877823A (enExample)
AT (1) ATE123225T1 (enExample)
CA (1) CA1341642C (enExample)
DE (2) DE3280468T2 (enExample)
DK (2) DK163931C (enExample)
ES (1) ES514712A0 (enExample)
GR (1) GR76274B (enExample)
HK (1) HK64591A (enExample)
IE (1) IE65996B1 (enExample)
PT (1) PT75374B (enExample)
SG (1) SG58191G (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58109427A (ja) * 1981-08-31 1983-06-29 ジエネンテツク・インコ−ポレ−テツド 酵母菌中でのｂ型肝炎表面抗原の製造
JPS5971694A (ja) * 1982-09-08 1984-04-23 スミスクライン・バイオロジカルス・ソシエテ・アノニム 肝炎ｂ型ウイルスワクチン
JPS60104020A (ja) * 1983-10-14 1985-06-08 メルク　エンド　カムパニー　インコーポレーテツド Ａ型肝炎‐タンパク質サブユニツト抗原
JPS62208288A (ja) * 1986-01-31 1987-09-12 メルク　エンド　カムパニ−　インコ−ポレ−テツド 酵母内でｂ型肝炎ウイルス蛋白を生産する方法
JPS62286930A (ja) * 1986-06-05 1987-12-12 Handai Biseibutsubiyou Kenkyukai フラビウイルス抗原
JPS6322098A (ja) * 1986-06-18 1988-01-29 Handai Biseibutsubiyou Kenkyukai Ｂ型肝炎ウイルス抗原とその製造法
JPS63501611A (ja) * 1985-10-04 1988-06-23 ジ・アップジョン・カンパニ− 偽狂犬病ウイルス蛋白質
JPH0227990A (ja) * 1988-05-13 1990-01-30 Phillips Petroleum Co メチロトロフィック酵母におけるＢ型肝炎ＳおよびＰｒｅＳ↓２タンパク質の発現
JPH02501107A (ja) * 1986-11-01 1990-04-19 ブリティッシュ　バイオーテクノロジー　リミテッド 微粒子ハイブリッドｈｉｖ抗原
JPH07106141B2 (ja) * 1985-08-15 1995-11-15 アムジエン 酵母細胞から外来遺伝子生成物の発現を増進させるための培地および方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58146281A (ja) * 1981-10-19 1983-08-31 Suntory Ltd 酵母細胞の形質転換法
DE3381619D1 (de) * 1982-08-16 1990-07-05 Chemo Sero Therapeut Res Inst Pendelvektor.
US4876197A (en) * 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
CA1341116C (en) * 1983-02-22 2000-10-17 Rae Lyn Burke Yeast expression systems with vectors having gapdh or pyk promoters and synthesis or foreign protein
JPS6078999A (ja) * 1983-10-05 1985-05-04 Chemo Sero Therapeut Res Inst ＨＢｓ抗原の精製方法
DE3587759T2 (de) * 1984-05-11 1994-07-07 Chiron Corp., Emeryville, Calif. Erhöhte Hefetranskription unter Verwendung einer Hybridkonstruktion der Promotorregion.
DE3585578D1 (de) * 1984-06-18 1992-04-16 Chiron Corp Hepatitisoberflaechenantigenpartikelvakzin.
US4624918A (en) * 1984-07-09 1986-11-25 Genentech, Inc. Purification process for hepatitis surface antigen and product thereof
US4722840A (en) * 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
EP0175261B1 (en) * 1984-09-12 1991-12-11 Chiron Corporation Hybrid particle immunogens
DE3689899T2 (de) * 1985-04-08 1994-09-15 Amgen Verfahren und hybridpromotor zur steuerung der exogenen gentranskription.
US4649192A (en) * 1985-05-30 1987-03-10 Smith Kline-Rit Method for the isolation and purification of hepatitis B surface antigen using polysorbate
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
JPH0789951B2 (ja) * 1986-06-18 1995-10-04 財団法人阪大微生物病研究会 遺伝子発現産物の精製法
IL79740A0 (en) * 1986-08-17 1986-11-30 Yeda Res & Dev Hepatitis vaccine
EP0280470B1 (en) * 1987-02-27 1993-07-07 Merck & Co. Inc. Method of purifying recombinant pres-1/s-2/s hepatitis b antigen from yeast
US5026828A (en) * 1987-02-27 1991-06-25 Merck & Co., Inc. Method of purifying recombinant pres-1/S-2/S/S hepatitis B antigen from yeast
CA1341074C (en) * 1987-06-22 2000-08-08 Hans A. Thoma Hbv surface antigen particles, prepared by recombinant dna processes, composed of different epitopes, selected from the pre-s and s-peptides as a new vaccine
US5011915A (en) * 1987-10-26 1991-04-30 Merck & Co., Inc. Process for purifying recombinant hepatitis antigens
EP0491077A1 (en) * 1990-12-19 1992-06-24 Medeva Holdings B.V. A composition used as a therapeutic agent against chronic viral hepatic diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55104887A (en) * 1978-12-22 1980-08-11 Biogen Nv Rearranged dna molecule and method
JPS5739784A (en) * 1980-04-22 1982-03-05 Pasteur Institut Conversion of cell culture
JPH0314840A (ja) * 1988-12-28 1991-01-23 Kureha Chem Ind Co Ltd 弗化ビニリデン系ポリマー二軸冷延伸フィルムおよびその製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2270892A1 (en) * 1974-05-14 1975-12-12 Inst Francais D Immunologie Vaccines from attenuated viruses - which have been serially incubated with yeast cells, especially Saccharomyces cerevisiae
IE52036B1 (en) * 1979-05-24 1987-05-27 Univ California Non-passageable viruses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55104887A (en) * 1978-12-22 1980-08-11 Biogen Nv Rearranged dna molecule and method
JPS5739784A (en) * 1980-04-22 1982-03-05 Pasteur Institut Conversion of cell culture
JPH0314840A (ja) * 1988-12-28 1991-01-23 Kureha Chem Ind Co Ltd 弗化ビニリデン系ポリマー二軸冷延伸フィルムおよびその製造方法

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58109427A (ja) * 1981-08-31 1983-06-29 ジエネンテツク・インコ−ポレ−テツド 酵母菌中でのｂ型肝炎表面抗原の製造
JPS5971694A (ja) * 1982-09-08 1984-04-23 スミスクライン・バイオロジカルス・ソシエテ・アノニム 肝炎ｂ型ウイルスワクチン
JPH02116A (ja) * 1982-09-08 1990-01-05 Smith Kline Rit 肝炎ｂ型ウイルスワクチン
JPH02231084A (ja) * 1982-09-08 1990-09-13 Smithkline Biologicals Sa 肝炎ｂ型ウィルスワクチン用組換型ｄｎａ分子
JPS60104020A (ja) * 1983-10-14 1985-06-08 メルク　エンド　カムパニー　インコーポレーテツド Ａ型肝炎‐タンパク質サブユニツト抗原
JPH07106141B2 (ja) * 1985-08-15 1995-11-15 アムジエン 酵母細胞から外来遺伝子生成物の発現を増進させるための培地および方法
JPS63501611A (ja) * 1985-10-04 1988-06-23 ジ・アップジョン・カンパニ− 偽狂犬病ウイルス蛋白質
JPS62208288A (ja) * 1986-01-31 1987-09-12 メルク　エンド　カムパニ−　インコ−ポレ−テツド 酵母内でｂ型肝炎ウイルス蛋白を生産する方法
JPS62286930A (ja) * 1986-06-05 1987-12-12 Handai Biseibutsubiyou Kenkyukai フラビウイルス抗原
JPS6322098A (ja) * 1986-06-18 1988-01-29 Handai Biseibutsubiyou Kenkyukai Ｂ型肝炎ウイルス抗原とその製造法
JPH02501107A (ja) * 1986-11-01 1990-04-19 ブリティッシュ　バイオーテクノロジー　リミテッド 微粒子ハイブリッドｈｉｖ抗原
JPH0227990A (ja) * 1988-05-13 1990-01-30 Phillips Petroleum Co メチロトロフィック酵母におけるＢ型肝炎ＳおよびＰｒｅＳ↓２タンパク質の発現

Also Published As

Publication number Publication date
ES8400877A1 (es) 1983-11-16
HK64591A (en) 1991-08-23
EP0072318A2 (en) 1983-02-16
DE3280468D1 (de) 1995-07-06
ATE123225T1 (de) 1995-06-15
PT75374A (en) 1982-09-01
CA1341642C (en) 2023-02-21
SG58191G (en) 1993-02-19
EP0072318B1 (en) 1990-05-30
DK163931C (da) 1992-09-14
JPH0526798B2 (enExample) 1993-04-19
DK347682A (da) 1983-02-05
DK163931B (da) 1992-04-21
PT75374B (en) 1985-12-13
EP0072318A3 (en) 1983-03-16
DE3280468T2 (de) 1995-12-07
DE3280186D1 (de) 1990-07-05
ES514712A0 (es) 1983-11-16
GR76274B (enExample) 1984-08-04
DK114791D0 (da) 1991-06-14
DK114791A (da) 1991-06-14
IE65996B1 (en) 1995-11-29
DK169152B1 (da) 1994-08-29

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