JPS5867699A - プラスミド - Google Patents
プラスミドInfo
- Publication number
- JPS5867699A JPS5867699A JP56165511A JP16551181A JPS5867699A JP S5867699 A JPS5867699 A JP S5867699A JP 56165511 A JP56165511 A JP 56165511A JP 16551181 A JP16551181 A JP 16551181A JP S5867699 A JPS5867699 A JP S5867699A
- Authority
- JP
- Japan
- Prior art keywords
- plasmid
- dna
- coryneform bacteria
- molecular weight
- producing coryneform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013612 plasmid Substances 0.000 title claims abstract description 37
- 108091008146 restriction endonucleases Proteins 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 238000003776 cleavage reaction Methods 0.000 claims description 10
- 244000005700 microbiome Species 0.000 claims description 10
- 230000007017 scission Effects 0.000 claims description 10
- 241000186226 Corynebacterium glutamicum Species 0.000 abstract description 15
- 241000186031 Corynebacteriaceae Species 0.000 abstract description 12
- 238000000246 agarose gel electrophoresis Methods 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 4
- 239000006228 supernatant Substances 0.000 abstract description 4
- 238000012270 DNA recombination Methods 0.000 abstract description 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract description 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 2
- 239000000047 product Substances 0.000 abstract description 2
- 238000005199 ultracentrifugation Methods 0.000 abstract description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N Glutamine Chemical compound OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 4
- 230000004544 DNA amplification Effects 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 description 22
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 20
- 238000000034 method Methods 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000002609 medium Substances 0.000 description 11
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 10
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 229940049906 glutamate Drugs 0.000 description 9
- 229930195712 glutamate Natural products 0.000 description 9
- 241000186216 Corynebacterium Species 0.000 description 8
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 8
- 229960002989 glutamic acid Drugs 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 239000004472 Lysine Substances 0.000 description 5
- 229960002685 biotin Drugs 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 239000004202 carbamide Substances 0.000 description 5
- 238000012258 culturing Methods 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 241000186146 Brevibacterium Species 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 235000013922 glutamic acid Nutrition 0.000 description 4
- 239000004220 glutamic acid Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 241000186063 Arthrobacter Species 0.000 description 3
- 235000019766 L-Lysine Nutrition 0.000 description 3
- 239000001888 Peptone Substances 0.000 description 3
- 108010080698 Peptones Proteins 0.000 description 3
- 239000011543 agarose gel Substances 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 239000013611 chromosomal DNA Substances 0.000 description 3
- 241000186254 coryneform bacterium Species 0.000 description 3
- 238000001493 electron microscopy Methods 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 235000019319 peptone Nutrition 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 201000004283 Shwachman-Diamond syndrome Diseases 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 238000000432 density-gradient centrifugation Methods 0.000 description 2
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000012262 fermentative production Methods 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 235000018977 lysine Nutrition 0.000 description 2
- 229960000274 lysozyme Drugs 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 235000010335 lysozyme Nutrition 0.000 description 2
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 229960000344 thiamine hydrochloride Drugs 0.000 description 2
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 2
- 239000011747 thiamine hydrochloride Substances 0.000 description 2
- 241001156739 Actinobacteria <phylum> Species 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 108020004638 Circular DNA Proteins 0.000 description 1
- 241000186145 Corynebacterium ammoniagenes Species 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001646716 Escherichia coli K-12 Species 0.000 description 1
- 102100034003 FAU ubiquitin-like and ribosomal protein S30 Human genes 0.000 description 1
- 241000606766 Haemophilus parainfluenzae Species 0.000 description 1
- 101000732045 Homo sapiens FAU ubiquitin-like and ribosomal protein S30 Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241000144155 Microbacterium ammoniaphilum Species 0.000 description 1
- 241000203720 Pimelobacter simplex Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241000187561 Rhodococcus erythropolis Species 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- 241000319304 [Brevibacterium] flavum Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- SDIXRDNYIMOKSG-UHFFFAOYSA-L disodium methyl arsenate Chemical compound [Na+].[Na+].C[As]([O-])([O-])=O SDIXRDNYIMOKSG-UHFFFAOYSA-L 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000003544 thiamines Chemical class 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56165511A JPS5867699A (ja) | 1981-10-16 | 1981-10-16 | プラスミド |
| DE8282109562T DE3279371D1 (en) | 1981-10-16 | 1982-10-15 | Plasmid |
| EP19820109562 EP0077548B1 (en) | 1981-10-16 | 1982-10-15 | Plasmid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56165511A JPS5867699A (ja) | 1981-10-16 | 1981-10-16 | プラスミド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5867699A true JPS5867699A (ja) | 1983-04-22 |
| JPS6411280B2 JPS6411280B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-02-23 |
Family
ID=15813777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56165511A Granted JPS5867699A (ja) | 1981-10-16 | 1981-10-16 | プラスミド |
Country Status (3)
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58105999A (ja) * | 1981-12-17 | 1983-06-24 | Kyowa Hakko Kogyo Co Ltd | 新規ベクタ−プラスミド |
| JPS58126789A (ja) * | 1981-12-29 | 1983-07-28 | Kyowa Hakko Kogyo Co Ltd | レースレオニンの製造法 |
| JPS6062994A (ja) * | 1983-08-24 | 1985-04-11 | Ajinomoto Co Inc | 発酵法によるｌ−リジンの製造法 |
| JPS61152289A (ja) * | 1984-12-27 | 1986-07-10 | Ajinomoto Co Inc | プラスミド及びそれを有する細菌 |
| JPH0195785A (ja) * | 1987-10-08 | 1989-04-13 | Mitsubishi Petrochem Co Ltd | プラスミドｐＢＹ５０３ |
| US5547864A (en) * | 1993-01-13 | 1996-08-20 | Ajinomoto Co., Inc. | Coryneform bacteria deficient in a cell surface protein |
| WO2008114721A1 (ja) | 2007-03-14 | 2008-09-25 | Ajinomoto Co., Inc. | Ｌ－グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| WO2009028582A1 (ja) | 2007-08-29 | 2009-03-05 | Research Institute Of Innovative Technology For The Earth | イソプロパノール生産能を有する形質転換体 |
| WO2009031565A1 (ja) | 2007-09-04 | 2009-03-12 | Ajinomoto Co., Inc. | アミノ酸生産微生物及びアミノ酸の製造法 |
| WO2009088049A1 (ja) | 2008-01-10 | 2009-07-16 | Ajinomoto Co., Inc. | 発酵法による目的物質の製造法 |
| WO2009131040A1 (ja) | 2008-04-25 | 2009-10-29 | 財団法人地球環境産業技術研究機構 | イソプロパノール生産能を有するコリネ型細菌の形質転換体 |
| WO2009154122A1 (ja) | 2008-06-17 | 2009-12-23 | 財団法人地球環境産業技術研究機構 | Ｄ－キシロース利用機能が向上したコリネ型細菌形質転換体 |
| WO2010113832A1 (ja) | 2009-03-30 | 2010-10-07 | 財団法人地球環境産業技術研究機構 | コリネ型細菌形質転換体及びそれを用いるイソブタノールの製造方法 |
| WO2012033112A1 (ja) | 2010-09-08 | 2012-03-15 | グリーンフェノール・高機能フェノール樹脂製造技術研究組合 | コリネ型細菌形質転換体及びそれを用いるフェノールの製造方法 |
| WO2012063862A1 (ja) | 2010-11-10 | 2012-05-18 | グリーンフェノール・高機能フェノール樹脂製造技術研究組合 | コリネ型細菌形質転換体及びそれを用いるフェノールの製造方法 |
| WO2012063860A1 (ja) | 2010-11-10 | 2012-05-18 | グリーンフェノール・高機能フェノール樹脂製造技術研究組合 | コリネ型細菌形質転換体及びそれを用いるフェノールの製造方法 |
| WO2012067174A1 (ja) | 2010-11-18 | 2012-05-24 | グリーンフェノール・高機能フェノール樹脂製造技術研究組合 | コリネ型細菌形質転換体及びそれを用いるフェノールの製造方法 |
| WO2012090978A1 (ja) | 2010-12-28 | 2012-07-05 | 公益財団法人地球環境産業技術研究機構 | コリネ型細菌形質転換体及びそれを用いるアニリンの製造方法 |
| WO2013027709A1 (ja) | 2011-08-22 | 2013-02-28 | 公益財団法人地球環境産業技術研究機構 | コリネ型細菌形質転換体及びそれを用いるバリンの製造方法 |
| WO2013069634A1 (ja) | 2011-11-11 | 2013-05-16 | 味の素株式会社 | 発酵法による目的物質の製造法 |
| WO2014007273A1 (ja) | 2012-07-03 | 2014-01-09 | 株式会社ジナリス | 有用微生物および目的物質の製造方法 |
| EP2949660A1 (en) | 2004-12-28 | 2015-12-02 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing l-glutamic acid |
| US10704063B2 (en) | 2015-05-19 | 2020-07-07 | Lucite International Uk Limited | Process for the biological production of methacrylic acid and derivatives thereof |
| US10961526B2 (en) | 2016-03-28 | 2021-03-30 | Research Institute Of Innovative Technology For The Earth | Transformant, and method for producing protocatechuic acid or salt thereof using same |
| US10988743B2 (en) | 2016-02-26 | 2021-04-27 | Research Institute Of Innovative Technology For The Earth | Coryneform bacterial transformant and method for producing 4-aminobenzoic acid or salt thereof using same |
| WO2024033603A1 (en) | 2022-08-08 | 2024-02-15 | Mitsubishi Chemical UK Limited | Process for the biological production of methacrylic acid and derivatives thereof |
| US11981951B2 (en) | 2016-11-23 | 2024-05-14 | Mitsubishi Chemical UK Limited | Process for the production of methyl methacrylate |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5236831A (en) * | 1981-12-29 | 1993-08-17 | Kiowa Hakko Kogyo Co., Ltd. | Amino acid synthesis in corynebacteria using E. coli genes |
| US4601983A (en) * | 1983-06-15 | 1986-07-22 | Ajinomoto Co., Inc. | Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine |
| GB2165546B (en) * | 1984-08-21 | 1989-05-17 | Asahi Chemical Ind | A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom |
| JPS61268185A (ja) * | 1984-12-27 | 1986-11-27 | Asahi Chem Ind Co Ltd | グルタミン酸デヒドロゲナ−ゼ産生遺伝子を含むｄｎａ断片 |
| JPH0755155B2 (ja) * | 1986-09-10 | 1995-06-14 | 協和醗酵工業株式会社 | アミノ酸の製造法 |
| JPH0728749B2 (ja) * | 1986-09-22 | 1995-04-05 | 協和醗酵工業株式会社 | Ｌ−アルギニンの製造法 |
| SK285201B6 (sk) * | 1996-12-05 | 2006-08-03 | Ajinomoto Co., Inc. | Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7 |
| US6255086B1 (en) | 1999-02-01 | 2001-07-03 | Ajinomoto Co., Inc. | Carbamoyl-phosphate synthetase gene of coryneform bacteria and method for producing L-arginine |
| US20030124685A1 (en) * | 1999-02-01 | 2003-07-03 | Yoko Kuwabara | Carbamoyl-phosphate synthetase gene of coryneform bacteria and method for producing l-arginine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56160997A (en) * | 1980-05-16 | 1981-12-11 | Ajinomoto Co Inc | Preparation of l-lysine by fermenaition method |
| GB2076853B (en) * | 1980-04-17 | 1983-12-21 | Ajinomoto Kk | L-glutamic acid producing microorganisms |
| JPS57186496A (en) * | 1981-05-11 | 1982-11-16 | Ajinomoto Co Inc | Preparation of l-threonine by fermentation |
| JPS58893A (ja) * | 1981-06-25 | 1983-01-06 | Ajinomoto Co Inc | 発酵法によるｌ−イソロイシンの製造法 |
-
1981
- 1981-10-16 JP JP56165511A patent/JPS5867699A/ja active Granted
-
1982
- 1982-10-15 EP EP19820109562 patent/EP0077548B1/en not_active Expired
- 1982-10-15 DE DE8282109562T patent/DE3279371D1/de not_active Expired
Cited By (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58105999A (ja) * | 1981-12-17 | 1983-06-24 | Kyowa Hakko Kogyo Co Ltd | 新規ベクタ−プラスミド |
| JPS58126789A (ja) * | 1981-12-29 | 1983-07-28 | Kyowa Hakko Kogyo Co Ltd | レースレオニンの製造法 |
| JPS6062994A (ja) * | 1983-08-24 | 1985-04-11 | Ajinomoto Co Inc | 発酵法によるｌ−リジンの製造法 |
| JPS61152289A (ja) * | 1984-12-27 | 1986-07-10 | Ajinomoto Co Inc | プラスミド及びそれを有する細菌 |
| JPH0195785A (ja) * | 1987-10-08 | 1989-04-13 | Mitsubishi Petrochem Co Ltd | プラスミドｐＢＹ５０３ |
| US5547864A (en) * | 1993-01-13 | 1996-08-20 | Ajinomoto Co., Inc. | Coryneform bacteria deficient in a cell surface protein |
| US5681717A (en) * | 1993-01-13 | 1997-10-28 | Ajinomoto Co., Inc. | DNA encoding novel cell surface protein |
| EP2949660A1 (en) | 2004-12-28 | 2015-12-02 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing l-glutamic acid |
| WO2008114721A1 (ja) | 2007-03-14 | 2008-09-25 | Ajinomoto Co., Inc. | Ｌ－グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| EP2657332A1 (en) | 2007-03-14 | 2013-10-30 | Ajinomoto Co., Inc. | Methods for producing an amino acid of the L-glutamic acid family |
| WO2009028582A1 (ja) | 2007-08-29 | 2009-03-05 | Research Institute Of Innovative Technology For The Earth | イソプロパノール生産能を有する形質転換体 |
| WO2009031565A1 (ja) | 2007-09-04 | 2009-03-12 | Ajinomoto Co., Inc. | アミノ酸生産微生物及びアミノ酸の製造法 |
| WO2009088049A1 (ja) | 2008-01-10 | 2009-07-16 | Ajinomoto Co., Inc. | 発酵法による目的物質の製造法 |
| EP2749652A2 (en) | 2008-01-10 | 2014-07-02 | Ajinomoto Co., Inc. | A method for producing a target substance by fermentation |
| WO2009131040A1 (ja) | 2008-04-25 | 2009-10-29 | 財団法人地球環境産業技術研究機構 | イソプロパノール生産能を有するコリネ型細菌の形質転換体 |
| WO2009154122A1 (ja) | 2008-06-17 | 2009-12-23 | 財団法人地球環境産業技術研究機構 | Ｄ－キシロース利用機能が向上したコリネ型細菌形質転換体 |
| WO2010113832A1 (ja) | 2009-03-30 | 2010-10-07 | 財団法人地球環境産業技術研究機構 | コリネ型細菌形質転換体及びそれを用いるイソブタノールの製造方法 |
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| WO2012067174A1 (ja) | 2010-11-18 | 2012-05-24 | グリーンフェノール・高機能フェノール樹脂製造技術研究組合 | コリネ型細菌形質転換体及びそれを用いるフェノールの製造方法 |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP0077548A2 (en) | 1983-04-27 |
| EP0077548A3 (en) | 1984-04-25 |
| JPS6411280B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-02-23 |
| DE3279371D1 (en) | 1989-02-23 |
| EP0077548B1 (en) | 1989-01-18 |
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