JPS57209270A - Proline derivative - Google Patents

Proline derivative

Info

Publication number
JPS57209270A
JPS57209270A JP56094002A JP9400281A JPS57209270A JP S57209270 A JPS57209270 A JP S57209270A JP 56094002 A JP56094002 A JP 56094002A JP 9400281 A JP9400281 A JP 9400281A JP S57209270 A JPS57209270 A JP S57209270A
Authority
JP
Japan
Prior art keywords
compound
amino acid
cyclohexanecarbonyl
sarcosine
glycine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56094002A
Other languages
English (en)
Other versions
JPS6313433B2 (ja
Inventor
Sadao Tanaka
Kiyonori Kuromaru
Yasuo Fujimura
Isao Matsunaga
Noriko Obata
Jiyunichirou Aono
Yoshikazu Hinohara
Hideki Nakano
Masafumi Fukushima
Hiroyuki Nahata
Kazunari Sakai
Shunichi Hata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP56094002A priority Critical patent/JPS57209270A/ja
Priority to AT0558581A priority patent/AT377496B/de
Priority to GB08215345A priority patent/GB2102412B/en
Priority to ZA823779A priority patent/ZA823779B/xx
Priority to CA000404054A priority patent/CA1235120A/en
Priority to IL65954A priority patent/IL65954A/xx
Priority to IT67772/82A priority patent/IT1157053B/it
Priority to FI822171A priority patent/FI75804C/fi
Priority to SU823450352A priority patent/SU1316556A3/ru
Priority to MX193189A priority patent/MX155724A/es
Priority to MX010799A priority patent/MX171888B/es
Priority to NO821997A priority patent/NO156408C/no
Priority to DK273082A priority patent/DK156054C/da
Priority to HU821976A priority patent/HU188177B/hu
Priority to BE0/208378A priority patent/BE893553A/fr
Priority to CH3751/82A priority patent/CH651825A5/de
Priority to SE8203814A priority patent/SE453595B/sv
Priority to DE19823222779 priority patent/DE3222779A1/de
Priority to NL8202472A priority patent/NL193282C/nl
Priority to ES513277A priority patent/ES513277A0/es
Priority to PT75076A priority patent/PT75076B/pt
Priority to KR8202740A priority patent/KR890000769B1/ko
Priority to FR8210796A priority patent/FR2508040B1/fr
Priority to AT0238582A priority patent/AT390619B/de
Priority to SU823514502A priority patent/SU1272982A3/ru
Publication of JPS57209270A publication Critical patent/JPS57209270A/ja
Priority to ES520582A priority patent/ES8403868A1/es
Priority to AT0362883A priority patent/AT386603B/de
Publication of JPS6313433B2 publication Critical patent/JPS6313433B2/ja
Priority to KR1019880015389A priority patent/KR890000770B1/ko
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D2205/00—Indexing scheme relating to details of means for transferring or converting the output of a sensing member
    • G01D2205/70—Position sensors comprising a moving target with particular shapes, e.g. of soft magnetic targets
    • G01D2205/77—Specific profiles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP56094002A 1981-06-19 1981-06-19 Proline derivative Granted JPS57209270A (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
JP56094002A JPS57209270A (en) 1981-06-19 1981-06-19 Proline derivative
AT0558581A AT377496B (de) 1981-06-19 1981-12-29 Vorrichtung zum anwickeln einer warenbahn auf eine neu eingelegte wickelhuelse in einer doppeltragwalzen-wickelmaschine
GB08215345A GB2102412B (en) 1981-06-19 1982-05-26 Proline derivatives and process for producing the same
ZA823779A ZA823779B (en) 1981-06-19 1982-05-28 Proline derivatives and process for producing the same
CA000404054A CA1235120A (en) 1981-06-19 1982-05-28 Proline derivatives and process for producing the same
IL65954A IL65954A (en) 1981-06-19 1982-06-02 Proline derivatives and process for producing them
IT67772/82A IT1157053B (it) 1981-06-19 1982-06-16 Derivati della prolina e procedimento per la loro preparazione
FI822171A FI75804C (fi) 1981-06-19 1982-06-16 Foerfarande foer framstaellning av terapeutiskt aktivt prolinderivat.
SU823450352A SU1316556A3 (ru) 1981-06-19 1982-06-16 Способ получени производных пролина или их фармацевтически приемлемых солей
MX193189A MX155724A (es) 1981-06-19 1982-06-16 Procedimiento para la preparacion de derivados de prolina
MX010799A MX171888B (es) 1981-06-19 1982-06-16 Procedimiento para la preparacion de derivados de prolina
NO821997A NO156408C (no) 1981-06-19 1982-06-16 AnalogifremgangsmŸte for fremstilling av terapeutisk aktive l-prolinderivater.
CH3751/82A CH651825A5 (de) 1981-06-19 1982-06-17 Prolinderivate sowie verfahren fuer ihre herstellung.
HU821976A HU188177B (en) 1981-06-19 1982-06-17 Process for producing new proline derivatives
BE0/208378A BE893553A (fr) 1981-06-19 1982-06-17 Derives de la proline et procede pour les preparer
DK273082A DK156054C (da) 1981-06-19 1982-06-17 Analogifremgangsmaade til fremstilling af n-(3-acylthio-2-methylpropanoyl)-prolinforbindelser eller salte heraf
SE8203814A SE453595B (sv) 1981-06-19 1982-06-18 Prolinderivat
DE19823222779 DE3222779A1 (de) 1981-06-19 1982-06-18 Prolinderivate und verfahren zu deren herstellung
NL8202472A NL193282C (nl) 1981-06-19 1982-06-18 Bloeddrukverlagend prolinederivaat en werkwijze voor het bereiden van een bloeddrukverlagend geneesmiddel.
ES513277A ES513277A0 (es) 1981-06-19 1982-06-18 Un procedimiento para producir derivados de prolina.
PT75076A PT75076B (en) 1981-06-19 1982-06-18 Proline derivatives and process for producing the same
KR8202740A KR890000769B1 (ko) 1981-06-19 1982-06-19 프롤린 유도체의 제법
FR8210796A FR2508040B1 (fr) 1981-06-19 1982-06-21 Derives de proline, leur procede de preparation et medicament les contenant
AT0238582A AT390619B (de) 1981-06-19 1982-06-21 Verfahren zur herstellung von neuen prolinderivaten
SU823514502A SU1272982A3 (ru) 1981-06-19 1982-11-25 Способ получени производных пролина или их фармацевтически приемлемых солей
ES520582A ES8403868A1 (es) 1981-06-19 1983-03-14 Un procedimiento para producir derivados de prolina.
AT0362883A AT386603B (de) 1981-06-19 1983-10-11 Verfahren zur herstellung von neuen prolinderivaten
KR1019880015389A KR890000770B1 (ko) 1981-06-19 1988-11-22 프롤린 유도체의 제법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56094002A JPS57209270A (en) 1981-06-19 1981-06-19 Proline derivative

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP62063596A Division JPS6345252A (ja) 1987-03-18 1987-03-18 プロリン誘導体

Publications (2)

Publication Number Publication Date
JPS57209270A true JPS57209270A (en) 1982-12-22
JPS6313433B2 JPS6313433B2 (ja) 1988-03-25

Family

ID=14098203

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56094002A Granted JPS57209270A (en) 1981-06-19 1981-06-19 Proline derivative

Country Status (5)

Country Link
JP (1) JPS57209270A (ja)
AT (1) AT390619B (ja)
BE (1) BE893553A (ja)
SU (1) SU1272982A3 (ja)
ZA (1) ZA823779B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2362998T3 (es) 2002-08-19 2011-07-18 Pfizer Inc. Terapia de combinación para enfermedades hiperproliferativas.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
CN115819270A (zh) * 2021-09-17 2023-03-21 洛阳中科生物芯片技术有限公司 金刚烷胺半抗原、金刚烷胺抗原、制备方法以及金刚烷胺单克隆抗体及金刚烷胺检测试剂盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR73585B (ja) * 1978-09-11 1984-03-26 Univ Miami
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
PT70158A1 (en) * 1980-03-03 1982-03-01 Univ Miami Process for preparing anti-hypertensive agents

Also Published As

Publication number Publication date
ATA238582A (de) 1989-11-15
ZA823779B (en) 1984-01-25
JPS6313433B2 (ja) 1988-03-25
SU1272982A3 (ru) 1986-11-23
AT390619B (de) 1990-06-11
BE893553A (fr) 1982-12-17

Similar Documents

Publication Publication Date Title
EP0073143B1 (en) Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
EP0048763B1 (en) Sulfur-containing acylamino acids
DD201777A5 (de) Verfahren zum herstellen von neuen peptiden
EP0143746A2 (de) Substituierte 5-Amino-4-hydroxyvalerylderivate
DK0397420T3 (da) Enzymatisk fjernelse af en aminoterminal proteinsekvens
RU96101161A (ru) Новые пептидные производные
KR890014578A (ko) 펩타이드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물
PH25508A (en) Substituted quinazoline derivatives for use in gastrointestinal diseases
EP0215410A3 (en) Retro-inverso hexapeptide neurotensin analogs, process for their preparation and pharmaceutical compositions containing them
NZ337303A (en) Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates
JPS62270552A (ja) 新規ペプチド化合物
NZ214653A (en) 6-thioxanthine derivatives and pharmaceutical compositions
JPS57209270A (en) Proline derivative
RU94046091A (ru) Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения
EP0374098A2 (de) Retrovirale Proteasehemmer
MXPA02005537A (es) Nuevos acidos (aminopropil)metilfosfinicos.
EP0144290A2 (de) Substituierte Aethylendiaminderivate
US4500467A (en) Benzoylthio compounds, their preparation and their use as drugs
HU896606D0 (en) Process for the preparation of aminoacid derivatives inhibiting enzymes and pharmaceutical compositions thereof
CA1051802A (en) Amino acid derivatives and a process for the preparation thereof
EP0322633B1 (en) Mercapto-acylamino acid antihypertensives
JPH06500326A (ja) Ｎ―（メルカプトアルキル）尿素およびカルバミン酸塩
US5741781A (en) Mercaptoalkanoyldipeptide compounds
ES8403868A1 (es) Un procedimiento para producir derivados de prolina.
JPS5615256A (en) Novel tetrapeptide derivative