JPS57209270A - Proline derivative - Google Patents
Proline derivativeInfo
- Publication number
- JPS57209270A JPS57209270A JP56094002A JP9400281A JPS57209270A JP S57209270 A JPS57209270 A JP S57209270A JP 56094002 A JP56094002 A JP 56094002A JP 9400281 A JP9400281 A JP 9400281A JP S57209270 A JPS57209270 A JP S57209270A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- amino acid
- cyclohexanecarbonyl
- sarcosine
- glycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003147 proline derivatives Chemical class 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 t-butanecarbonyl Chemical group 0.000 abstract 3
- 239000004471 Glycine Substances 0.000 abstract 2
- 108010077895 Sarcosine Proteins 0.000 abstract 2
- 229940043230 sarcosine Drugs 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 206010031127 Orthostatic hypotension Diseases 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- NKLCHDQGUHMCGL-UHFFFAOYSA-N cyclohexylidenemethanone Chemical group O=C=C1CCCCC1 NKLCHDQGUHMCGL-UHFFFAOYSA-N 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D2205/00—Indexing scheme relating to details of means for transferring or converting the output of a sensing member
- G01D2205/70—Position sensors comprising a moving target with particular shapes, e.g. of soft magnetic targets
- G01D2205/77—Specific profiles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56094002A JPS57209270A (en) | 1981-06-19 | 1981-06-19 | Proline derivative |
| AT0558581A AT377496B (de) | 1981-06-19 | 1981-12-29 | Vorrichtung zum anwickeln einer warenbahn auf eine neu eingelegte wickelhuelse in einer doppeltragwalzen-wickelmaschine |
| GB08215345A GB2102412B (en) | 1981-06-19 | 1982-05-26 | Proline derivatives and process for producing the same |
| ZA823779A ZA823779B (en) | 1981-06-19 | 1982-05-28 | Proline derivatives and process for producing the same |
| CA000404054A CA1235120A (en) | 1981-06-19 | 1982-05-28 | Proline derivatives and process for producing the same |
| IL65954A IL65954A (en) | 1981-06-19 | 1982-06-02 | Proline derivatives and process for producing them |
| IT67772/82A IT1157053B (it) | 1981-06-19 | 1982-06-16 | Derivati della prolina e procedimento per la loro preparazione |
| SU823450352A SU1316556A3 (ru) | 1981-06-19 | 1982-06-16 | Способ получени производных пролина или их фармацевтически приемлемых солей |
| NO821997A NO156408C (no) | 1981-06-19 | 1982-06-16 | Analogifremgangsmte for fremstilling av terapeutisk aktive l-prolinderivater. |
| FI822171A FI75804C (fi) | 1981-06-19 | 1982-06-16 | Foerfarande foer framstaellning av terapeutiskt aktivt prolinderivat. |
| MX193189A MX155724A (es) | 1981-06-19 | 1982-06-16 | Procedimiento para la preparacion de derivados de prolina |
| MX010799A MX171888B (es) | 1981-06-19 | 1982-06-16 | Procedimiento para la preparacion de derivados de prolina |
| DK273082A DK156054C (da) | 1981-06-19 | 1982-06-17 | Analogifremgangsmaade til fremstilling af n-(3-acylthio-2-methylpropanoyl)-prolinforbindelser eller salte heraf |
| HU821976A HU188177B (en) | 1981-06-19 | 1982-06-17 | Process for producing new proline derivatives |
| CH3751/82A CH651825A5 (de) | 1981-06-19 | 1982-06-17 | Prolinderivate sowie verfahren fuer ihre herstellung. |
| BE0/208378A BE893553A (fr) | 1981-06-19 | 1982-06-17 | Derives de la proline et procede pour les preparer |
| SE8203814A SE453595B (sv) | 1981-06-19 | 1982-06-18 | Prolinderivat |
| NL8202472A NL193282C (nl) | 1981-06-19 | 1982-06-18 | Bloeddrukverlagend prolinederivaat en werkwijze voor het bereiden van een bloeddrukverlagend geneesmiddel. |
| ES513277A ES513277A0 (es) | 1981-06-19 | 1982-06-18 | Un procedimiento para producir derivados de prolina. |
| PT75076A PT75076B (en) | 1981-06-19 | 1982-06-18 | Proline derivatives and process for producing the same |
| DE19823222779 DE3222779A1 (de) | 1981-06-19 | 1982-06-18 | Prolinderivate und verfahren zu deren herstellung |
| KR8202740A KR890000769B1 (ko) | 1981-06-19 | 1982-06-19 | 프롤린 유도체의 제법 |
| AT0238582A AT390619B (de) | 1981-06-19 | 1982-06-21 | Verfahren zur herstellung von neuen prolinderivaten |
| FR8210796A FR2508040B1 (fr) | 1981-06-19 | 1982-06-21 | Derives de proline, leur procede de preparation et medicament les contenant |
| SU823514502A SU1272982A3 (ru) | 1981-06-19 | 1982-11-25 | Способ получени производных пролина или их фармацевтически приемлемых солей |
| ES520582A ES520582A0 (es) | 1981-06-19 | 1983-03-14 | Un procedimiento para producir derivados de prolina. |
| AT0362883A AT386603B (de) | 1981-06-19 | 1983-10-11 | Verfahren zur herstellung von neuen prolinderivaten |
| KR1019880015389A KR890000770B1 (ko) | 1981-06-19 | 1988-11-22 | 프롤린 유도체의 제법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56094002A JPS57209270A (en) | 1981-06-19 | 1981-06-19 | Proline derivative |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62063596A Division JPS6345252A (ja) | 1987-03-18 | 1987-03-18 | プロリン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57209270A true JPS57209270A (en) | 1982-12-22 |
| JPS6313433B2 JPS6313433B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-03-25 |
Family
ID=14098203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56094002A Granted JPS57209270A (en) | 1981-06-19 | 1981-06-19 | Proline derivative |
Country Status (5)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
| RU2269514C9 (ru) * | 1995-06-07 | 2006-05-27 | Джи-Пи-Ай Эн-Ай-Эл Холдингз, Инк. | Ингибиторы ферментативной активности ротамазы, являющиеся малыми молекулами |
| CZ20021432A3 (cs) * | 1999-10-28 | 2002-10-16 | Sankyo Company Limited | Benzamidové deriváty |
| PL375713A1 (en) | 2002-08-19 | 2005-12-12 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| HUE069590T2 (hu) | 2019-01-18 | 2025-03-28 | Astrazeneca Ab | PCSK9-gátló 6'-[[(1s,3s)-3-[[5-(difluormetoxi)-2-pirimidinil]amino]ciklopentil]amino][1(2h ),3'-bipiridin]-2-on és alkalmazására szolgáló eljárások |
| CN115819270B (zh) * | 2021-09-17 | 2025-03-21 | 洛阳中科生物芯片技术有限公司 | 金刚烷胺半抗原、金刚烷胺抗原、制备方法以及金刚烷胺单克隆抗体及金刚烷胺检测试剂盒 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR73585B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1978-09-11 | 1984-03-26 | Univ Miami | |
| ZA802420B (en) * | 1979-05-18 | 1981-04-29 | Squibb & Sons Inc | Aminoacyl derivatives of mercaptoacyl amino acids |
| PT70158A1 (en) * | 1980-03-03 | 1982-03-01 | Univ Miami | Process for preparing anti-hypertensive agents |
-
1981
- 1981-06-19 JP JP56094002A patent/JPS57209270A/ja active Granted
-
1982
- 1982-05-28 ZA ZA823779A patent/ZA823779B/xx unknown
- 1982-06-17 BE BE0/208378A patent/BE893553A/fr not_active IP Right Cessation
- 1982-06-21 AT AT0238582A patent/AT390619B/de not_active IP Right Cessation
- 1982-11-25 SU SU823514502A patent/SU1272982A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| SU1272982A3 (ru) | 1986-11-23 |
| ZA823779B (en) | 1984-01-25 |
| JPS6313433B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-03-25 |
| BE893553A (fr) | 1982-12-17 |
| ATA238582A (de) | 1989-11-15 |
| AT390619B (de) | 1990-06-11 |
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