JPS57176995A - Novel anthracyclinone glycoside and its preparation - Google Patents
Novel anthracyclinone glycoside and its preparationInfo
- Publication number
- JPS57176995A JPS57176995A JP56061766A JP6176681A JPS57176995A JP S57176995 A JPS57176995 A JP S57176995A JP 56061766 A JP56061766 A JP 56061766A JP 6176681 A JP6176681 A JP 6176681A JP S57176995 A JPS57176995 A JP S57176995A
- Authority
- JP
- Japan
- Prior art keywords
- acetyl
- compound
- preparation
- anthracyclinone
- aklavinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930182470 glycoside Natural products 0.000 title abstract 2
- 150000002338 glycosides Chemical class 0.000 title abstract 2
- -1 (monomethyl)amino, dimethylamino Chemical group 0.000 abstract 3
- MDUVOMDREZPQPI-UHFFFAOYSA-N Aklavinone Natural products CCC1(O)CC(O)c2c(O)c3C(=O)C4C(C=CC=C4O)C(=O)c3cc2C1C(=O)OC MDUVOMDREZPQPI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- RACGRCLGVYXIAO-YOKWENHESA-N aklavinone Chemical compound O=C1C2=C(O)C=CC=C2C(=O)C2=C1C(O)=C1[C@@H](O)C[C@@](CC)(O)[C@H](C(=O)OC)C1=C2 RACGRCLGVYXIAO-YOKWENHESA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56061766A JPS57176995A (en) | 1981-04-23 | 1981-04-23 | Novel anthracyclinone glycoside and its preparation |
CA000401265A CA1206472A (en) | 1981-04-23 | 1982-04-20 | Anthracyclinone glycosides and their preparation method |
EP82103319A EP0063776B1 (en) | 1981-04-23 | 1982-04-20 | Novel anthracyclinone glycosides and their preparation method |
US06/370,212 US4418192A (en) | 1981-04-23 | 1982-04-20 | Anthracyclinone trisaccharide compounds |
DE8282103319T DE3266311D1 (en) | 1981-04-23 | 1982-04-20 | Novel anthracyclinone glycosides and their preparation method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56061766A JPS57176995A (en) | 1981-04-23 | 1981-04-23 | Novel anthracyclinone glycoside and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57176995A true JPS57176995A (en) | 1982-10-30 |
Family
ID=13180567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56061766A Pending JPS57176995A (en) | 1981-04-23 | 1981-04-23 | Novel anthracyclinone glycoside and its preparation |
Country Status (5)
Country | Link |
---|---|
US (1) | US4418192A (ja) |
EP (1) | EP0063776B1 (ja) |
JP (1) | JPS57176995A (ja) |
CA (1) | CA1206472A (ja) |
DE (1) | DE3266311D1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0679039U (ja) * | 1993-04-06 | 1994-11-04 | 日本コロムビア株式会社 | 回転ノブ |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5874694A (ja) * | 1981-10-29 | 1983-05-06 | Sanraku Inc | アントラサイクリン誘導体 |
JPS5982395A (ja) * | 1982-11-02 | 1984-05-12 | Microbial Chem Res Found | アントラサイクリン化合物、その製造法およびその用途 |
DE3323025A1 (de) * | 1983-06-25 | 1985-01-10 | Hoechst Ag, 6230 Frankfurt | Anthracyclin-derivate, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika |
FR2551057B1 (fr) * | 1983-08-30 | 1986-07-18 | Hoechst Lab | Nouveaux aglycones utiles pour la preparation des antibiotiques et des antitumoraux de la serie des anthracyclines et leurs procedes de preparation |
DE3524117A1 (de) * | 1985-07-05 | 1987-02-05 | Hoechst Ag | Neue anthracyclin-tetrasaccharide, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatik |
DE3641833A1 (de) * | 1986-12-08 | 1988-06-09 | Behringwerke Ag | Zytostatisch wirksame anthracyclinderivate |
DE3706175A1 (de) * | 1987-02-26 | 1988-09-08 | Behringwerke Ag | Verwendung von lipophilen anthracyclinen zur behandlung "sekundaer" anthracyclin-resistenter tumoren, mittel enthaltend ein lipophiles anthracyclin und verfahren zu seiner herstellung |
US4918172A (en) * | 1987-10-06 | 1990-04-17 | Sanraku Incorporated | Anthracycline antibiotics |
DE3819092A1 (de) * | 1988-06-04 | 1989-12-14 | Behringwerke Ag | Zytostatisch wirksame anthracyclinderivate |
IT1282379B1 (it) * | 1996-04-24 | 1998-03-20 | Mini Ricerca Scient Tecnolog | Disaccaridi di antracicline antitumorali. |
WO2012082635A1 (en) * | 2010-12-13 | 2012-06-21 | Ancora Pharmaceuticals, Inc. | Synthetic oligosaccharide group a streptococcus |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3772269A (en) * | 1969-07-24 | 1973-11-13 | Ici America Inc | Glycoside compositions and process for the preparation thereof |
US4039663A (en) * | 1975-03-19 | 1977-08-02 | Societa' Farmaceutici Italia S.P.A. | Daunomycins, process for their uses and intermediates |
GB1561507A (en) * | 1976-11-17 | 1980-02-20 | Farmaceutici Italia | Snthracycline disaccharides |
US4216208A (en) * | 1978-07-31 | 1980-08-05 | Proter S.P.A. | N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity |
JPS55104225A (en) * | 1979-02-06 | 1980-08-09 | Sanraku Inc | Anthracyclines and their preparation |
JPS55108889A (en) * | 1979-02-15 | 1980-08-21 | Sanraku Inc | 4-o-methylaclacinomycin a and its preparation |
ZA802929B (en) * | 1979-05-22 | 1981-05-27 | Hoffmann La Roche | Novel tetracyclic compounds and process for the preparation thereof |
JPS6023679B2 (ja) * | 1979-07-13 | 1985-06-08 | メルシャン株式会社 | ロドマイシン群抗生物質とその製造法 |
US4318790A (en) * | 1980-03-17 | 1982-03-09 | The Upjohn Company | Photochemical process for preparing N-demethyl-derivatives of nogalamycin |
-
1981
- 1981-04-23 JP JP56061766A patent/JPS57176995A/ja active Pending
-
1982
- 1982-04-20 DE DE8282103319T patent/DE3266311D1/de not_active Expired
- 1982-04-20 US US06/370,212 patent/US4418192A/en not_active Expired - Fee Related
- 1982-04-20 CA CA000401265A patent/CA1206472A/en not_active Expired
- 1982-04-20 EP EP82103319A patent/EP0063776B1/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0679039U (ja) * | 1993-04-06 | 1994-11-04 | 日本コロムビア株式会社 | 回転ノブ |
Also Published As
Publication number | Publication date |
---|---|
DE3266311D1 (en) | 1985-10-24 |
CA1206472A (en) | 1986-06-24 |
EP0063776B1 (en) | 1985-09-18 |
EP0063776A1 (en) | 1982-11-03 |
US4418192A (en) | 1983-11-29 |
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