ES8101622A1 - Un procedimiento para la produccion de un derivado de antra-ciclina - Google Patents

Un procedimiento para la produccion de un derivado de antra-ciclina

Info

Publication number
ES8101622A1
ES8101622A1 ES488209A ES488209A ES8101622A1 ES 8101622 A1 ES8101622 A1 ES 8101622A1 ES 488209 A ES488209 A ES 488209A ES 488209 A ES488209 A ES 488209A ES 8101622 A1 ES8101622 A1 ES 8101622A1
Authority
ES
Spain
Prior art keywords
group
preparation
anthracycline derivatives
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488209A
Other languages
English (en)
Other versions
ES488209A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1170279A external-priority patent/JPS55104299A/ja
Priority claimed from JP11025579A external-priority patent/JPS5634695A/ja
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8101622A1 publication Critical patent/ES8101622A1/es
Publication of ES488209A0 publication Critical patent/ES488209A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE LA ANTRACICLINA. CONSISTE EN INTRODUCIR UN GRUPO ALQUILOXIETILO, TETRAHIDROFURANILO, TETRAHIDROPIRANILO, E-EMETOXITETRAHIDROPIRANILO O 6-ACETOXIMETILTETRAHIDROPIRANILO EN EL GRUPO HIDROXILO DE LA POSICION C-4'' DE UN DERIVADO DE LA ANTRACICLINA DE FORMULA (I), POR REACCION CON DIHIDROFURANO, DIHIDROPIRANO O UN ALQUIL, VINIL-ETER O LOS DERIVADOS CORRESPONDIENTES, EN UN DISOLVENTE ORGANICO INERTE Y EN PRESENCIA DE UN CATALIZADOR ACIDO. SE OBTIENE EL DERIVADO DE LA ANTRACICLINA, DEL QUE OPCIONALMENTE SE ELIMINA EL GRUPO ALCANCILO O FENILACETILO DE LA POSICION C-14 POR DESACILACION HIDROLITICA. *FORMULA* ACTIVIDAD ANTITUMORAL.
ES488209A 1979-02-03 1980-02-01 Un procedimiento para la produccion de un derivado de antra-ciclina Granted ES488209A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1170279A JPS55104299A (en) 1979-02-03 1979-02-03 Anthracycline compounds and their preparation
JP11025579A JPS5634695A (en) 1979-08-31 1979-08-31 Novel anthracycline derivative and its preparation

Publications (2)

Publication Number Publication Date
ES8101622A1 true ES8101622A1 (es) 1980-12-16
ES488209A0 ES488209A0 (es) 1980-12-16

Family

ID=26347196

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488209A Granted ES488209A0 (es) 1979-02-03 1980-02-01 Un procedimiento para la produccion de un derivado de antra-ciclina

Country Status (11)

Country Link
EP (1) EP0014853B1 (es)
AR (1) AR226694A1 (es)
AT (1) AT369384B (es)
AU (1) AU518278B2 (es)
CA (1) CA1136618A (es)
DE (1) DE3063557D1 (es)
DK (1) DK160616C (es)
ES (1) ES488209A0 (es)
FI (1) FI68057C (es)
NZ (1) NZ192758A (es)
PH (1) PH18200A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative
JPS6016998A (ja) * 1983-07-07 1985-01-28 Microbial Chem Res Found アントラサイクリン誘導体の製造方法
GB2169286A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxy-4'-halodoxorubicin-14-esters
GB2169285A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxydoxorubicin-14-esters
GB2169284A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Epidoxorubicin-14-esters
US4889926A (en) * 1987-06-12 1989-12-26 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Method for the synthesis of (2"R)-4'-O-tetra-hydropyranyladriamycim using 14-chloro-daunomycin as an intermediate
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates
US5776458A (en) * 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
IT1282379B1 (it) * 1996-04-24 1998-03-20 Mini Ricerca Scient Tecnolog Disaccaridi di antracicline antitumorali.
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
EP2376088B1 (en) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituted-2-amino-purine nucleoside phosphoramidates
TW201031675A (en) 2008-12-23 2010-09-01 Pharmasset Inc Synthesis of purine nucleosides
UY33311A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidatos de nucleosidos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52148064A (en) * 1976-05-31 1977-12-08 Microbial Chem Res Found Antitumors
GB1561507A (en) * 1976-11-17 1980-02-20 Farmaceutici Italia Snthracycline disaccharides
JPS5430146A (en) * 1977-08-05 1979-03-06 Microbial Chem Res Found Novel anthracycline derivatives and their preparation

Also Published As

Publication number Publication date
FI68057B (fi) 1985-03-29
PH18200A (en) 1985-04-25
FI800298A (fi) 1980-08-04
EP0014853A1 (en) 1980-09-03
AR226694A1 (es) 1982-08-13
FI68057C (fi) 1985-07-10
EP0014853B1 (en) 1983-06-01
CA1136618A (en) 1982-11-30
AU518278B2 (en) 1981-09-24
DK160616C (da) 1991-09-02
ATA51180A (de) 1982-05-15
DE3063557D1 (en) 1983-07-07
DK11480A (da) 1980-08-04
NZ192758A (en) 1982-03-09
DK160616B (da) 1991-04-02
ES488209A0 (es) 1980-12-16
AU5489580A (en) 1980-08-07
AT369384B (de) 1982-12-27

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