KR870003787A - 포스피노-탄화수소-8족 금속복합체 화합물을 함유하는 약학적 조성물 - Google Patents
포스피노-탄화수소-8족 금속복합체 화합물을 함유하는 약학적 조성물 Download PDFInfo
- Publication number
- KR870003787A KR870003787A KR1019860008963A KR860008963A KR870003787A KR 870003787 A KR870003787 A KR 870003787A KR 1019860008963 A KR1019860008963 A KR 1019860008963A KR 860008963 A KR860008963 A KR 860008963A KR 870003787 A KR870003787 A KR 870003787A
- Authority
- KR
- South Korea
- Prior art keywords
- sub
- iii
- hydrocarbon
- pharmaceutical compositions
- metal complex
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- -1 metal complex compounds Chemical class 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 3
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical group [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910002651 NO3 Inorganic materials 0.000 claims abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052785 arsenic Inorganic materials 0.000 claims abstract 2
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 claims abstract 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims abstract 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical group [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 abstract 1
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical group [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- MILUBEOXRNEUHS-UHFFFAOYSA-N iridium(3+) Chemical compound [Ir+3] MILUBEOXRNEUHS-UHFFFAOYSA-N 0.000 abstract 1
- 150000002736 metal compounds Chemical class 0.000 abstract 1
- WXHIJDCHNDBCNY-UHFFFAOYSA-N palladium dihydride Chemical compound [PdH2] WXHIJDCHNDBCNY-UHFFFAOYSA-N 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000004565 tumor cell growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0033—Iridium compounds
- C07F15/004—Iridium compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
- C07F15/0066—Palladium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0073—Rhodium compounds
- C07F15/008—Rhodium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/04—Nickel compounds
- C07F15/045—Nickel compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/06—Cobalt compounds
- C07F15/065—Cobalt compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 제암제로 사용되는 하기식의 포스피노-탄화수소-8족 금속복합체 화합물을 함유하는 약학적 조성물 및 약학적 허용단체 또는 희석제.상기식에서 D1=D2=포스포터스 또는 D1=포스터스 D2=비소 ; A=(CH2)2, (CH2)3또는 시스-CH=CH ; X1=X2(둘모두 존재할 경우)=할로 또는 니트레이토 또는 X1+X2=퍼옥소 ; Y (존재할 경우)=할라드, 니트레이트, 퍼클로레이트, 트리플레이트 또는 테트라할로페레이트(Ⅲ) ; n=0, 1 또는 2 ; M=Fe(Ⅱ), Fe(Ⅲ), Co(Ⅱ), Rh(Ⅰ), Rh(Ⅲ), Ir(Ⅰ), Ir(Ⅲ), Ni(Ⅱ) 또는 Pd(Ⅱ)이다.
- 제1항에 있어서, 조성물은 비경구적 투여를 위해 용량유니트로 사용되는 것을 특징으로 하는 조성물.
- 제1항의 화합물은 공지된 방법에 미리 제조되는 것을 특징으로 하는 화합물의 제조방법.
- 제3항에 있어서, 하기식으로 표현되는 TNO3, TNO6, TNO9, TNO15, TNO18, TNO21 및 TNO23 화합물을 제조하는 방법.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8502929 | 1985-10-25 | ||
| NL8502929A NL8502929A (nl) | 1985-10-25 | 1985-10-25 | Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR870003787A true KR870003787A (ko) | 1987-05-04 |
Family
ID=19846766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860008963A KR870003787A (ko) | 1985-10-25 | 1986-10-25 | 포스피노-탄화수소-8족 금속복합체 화합물을 함유하는 약학적 조성물 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4831170A (ko) |
| EP (1) | EP0227127B1 (ko) |
| JP (1) | JPS62161795A (ko) |
| KR (1) | KR870003787A (ko) |
| CN (3) | CN86107219A (ko) |
| AT (1) | ATE63122T1 (ko) |
| AU (1) | AU601954B2 (ko) |
| CA (1) | CA1269395A (ko) |
| DE (1) | DE3679045D1 (ko) |
| DK (1) | DK511786A (ko) |
| ES (1) | ES2039199T3 (ko) |
| FI (1) | FI85861C (ko) |
| GR (1) | GR3001910T3 (ko) |
| HU (2) | HU203557B (ko) |
| IL (1) | IL80416A0 (ko) |
| NL (1) | NL8502929A (ko) |
| NO (1) | NO172585B (ko) |
| NZ (1) | NZ218072A (ko) |
| PT (1) | PT83612B (ko) |
| YU (1) | YU45802B (ko) |
| ZA (1) | ZA868162B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010015755A (ko) * | 1997-10-15 | 2001-02-26 | 폴락스 바이오파르마큐티칼스 인코포레이티드 | 비소 화합물을 이용하여 1차 신형성 질환 및 전이성신형성 질환을 치료하는 조성물 및 방법 |
| JP5015451B2 (ja) * | 2005-04-18 | 2012-08-29 | 日本化学工業株式会社 | ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤 |
| WO2009081366A1 (en) * | 2007-12-20 | 2009-07-02 | Richard John Bowen | Palladium and platinum phosphine complexes and their use as anti-tumour agents |
| WO2009104167A1 (en) * | 2008-02-22 | 2009-08-27 | Mintek | A substance or composition for the treatment of cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3084179A (en) * | 1959-02-27 | 1963-04-02 | Ici Ltd | Phosphorous-containing-ligand stabilized transition metal compounds |
| US3345392A (en) * | 1964-03-24 | 1967-10-03 | American Cyanamid Co | Organophosphorus-copper complex compounds |
| GB1085762A (en) * | 1965-04-30 | 1967-10-04 | Ici Ltd | Complex organic iridium compounds and their use as catalysts |
| FR2116905A5 (fr) * | 1970-12-10 | 1972-07-21 | Inst Francais Du Petrole | Nouveaux coordinats bidentes,leur fabrication et leurs applications |
| US3939188A (en) * | 1972-03-24 | 1976-02-17 | Exxon Research And Engineering Company | Preparation of zerovalent phosphine substituted rhodium compounds and their use in the selective carbonylation of olefins |
| US3954821A (en) * | 1975-06-30 | 1976-05-04 | E. I. Du Pont De Nemours And Company | Carbon dioxide complexes of Rh, Ir, Ni, Pd, and Pt |
| US4268454A (en) * | 1978-12-21 | 1981-05-19 | Allied Chemical Corporation | Anionic group VIII metal hydride catalysts |
| US4302401A (en) * | 1980-01-23 | 1981-11-24 | Exxon Research & Engineering Co. | Tetraalkyl phosphonium substituted phosphine and amine transition metal complexes |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| CA1238854A (en) * | 1984-02-01 | 1988-07-05 | David T. Hill | ANTITUMOR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING TUMORS EMPLOYING ¬.alpha.,W- BIS(DISUBSTITUTEDPHOSPHINO)HYDROCARBON| DIGOLD (I) DIGOLD (III), DISILVER (I) AND DICOPPER (I) DERIVATIVES |
| CA1244764A (en) * | 1984-06-04 | 1988-11-15 | Randall K. Johnson | Tumor cell growth-inhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes |
-
1985
- 1985-10-25 NL NL8502929A patent/NL8502929A/nl not_active Application Discontinuation
-
1986
- 1986-10-23 AT AT86201853T patent/ATE63122T1/de not_active IP Right Cessation
- 1986-10-23 ES ES198686201853T patent/ES2039199T3/es not_active Expired - Lifetime
- 1986-10-23 EP EP86201853A patent/EP0227127B1/en not_active Expired - Lifetime
- 1986-10-23 DE DE8686201853T patent/DE3679045D1/de not_active Expired - Fee Related
- 1986-10-24 FI FI864327A patent/FI85861C/fi not_active IP Right Cessation
- 1986-10-24 US US06/922,655 patent/US4831170A/en not_active Expired - Fee Related
- 1986-10-24 HU HU903471A patent/HU203557B/hu not_active IP Right Cessation
- 1986-10-24 CA CA000521403A patent/CA1269395A/en not_active Expired - Fee Related
- 1986-10-24 NO NO864270A patent/NO172585B/no unknown
- 1986-10-24 DK DK511786A patent/DK511786A/da not_active Application Discontinuation
- 1986-10-24 YU YU181786A patent/YU45802B/sh unknown
- 1986-10-24 PT PT83612A patent/PT83612B/pt not_active IP Right Cessation
- 1986-10-24 IL IL80416A patent/IL80416A0/xx unknown
- 1986-10-24 HU HU864487A patent/HU200609B/hu not_active IP Right Cessation
- 1986-10-25 JP JP61252843A patent/JPS62161795A/ja active Pending
- 1986-10-25 CN CN198686107219A patent/CN86107219A/zh active Pending
- 1986-10-25 KR KR1019860008963A patent/KR870003787A/ko not_active Application Discontinuation
- 1986-10-27 ZA ZA868162A patent/ZA868162B/xx unknown
- 1986-10-27 AU AU64413/86A patent/AU601954B2/en not_active Ceased
- 1986-10-28 NZ NZ218072A patent/NZ218072A/en unknown
-
1991
- 1991-03-16 CN CN91101598A patent/CN1057962A/zh active Pending
- 1991-05-03 GR GR91400587T patent/GR3001910T3/el unknown
-
1992
- 1992-05-28 CN CN92104058A patent/CN1067430A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HU903471D0 (en) | 1990-12-28 |
| EP0227127A2 (en) | 1987-07-01 |
| NO864270D0 (no) | 1986-10-24 |
| NZ218072A (en) | 1990-12-21 |
| HUT44263A (en) | 1988-02-29 |
| FI85861C (fi) | 1992-06-10 |
| DK511786A (da) | 1987-04-26 |
| NO864270L (no) | 1987-04-27 |
| EP0227127B1 (en) | 1991-05-02 |
| GR3001910T3 (en) | 1992-11-23 |
| ZA868162B (en) | 1987-06-24 |
| HU200609B (en) | 1990-07-28 |
| PT83612A (en) | 1986-11-01 |
| CN86107219A (zh) | 1987-05-27 |
| CN1067430A (zh) | 1992-12-30 |
| FI85861B (fi) | 1992-02-28 |
| NL8502929A (nl) | 1987-05-18 |
| AU6441386A (en) | 1987-05-21 |
| FI864327A (fi) | 1987-04-26 |
| IL80416A0 (en) | 1987-01-30 |
| YU45802B (sh) | 1992-07-20 |
| ES2039199T3 (es) | 1993-09-16 |
| JPS62161795A (ja) | 1987-07-17 |
| HU203557B (en) | 1991-08-28 |
| FI864327A0 (fi) | 1986-10-24 |
| YU181786A (en) | 1988-02-29 |
| US4831170A (en) | 1989-05-16 |
| NO172585B (no) | 1993-05-03 |
| PT83612B (pt) | 1989-05-31 |
| CA1269395A (en) | 1990-05-22 |
| ATE63122T1 (de) | 1991-05-15 |
| CN1057962A (zh) | 1992-01-22 |
| AU601954B2 (en) | 1990-09-27 |
| DK511786D0 (da) | 1986-10-24 |
| DE3679045D1 (de) | 1991-06-06 |
| EP0227127A3 (en) | 1988-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |