JPS55313A - Imidazole derivative - Google Patents

Imidazole derivative

Info

Publication number
JPS55313A
JPS55313A JP7127378A JP7127378A JPS55313A JP S55313 A JPS55313 A JP S55313A JP 7127378 A JP7127378 A JP 7127378A JP 7127378 A JP7127378 A JP 7127378A JP S55313 A JPS55313 A JP S55313A
Authority
JP
Japan
Prior art keywords
formula
imidazole derivative
imidazole
imidazolylmethyl
thromboxane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7127378A
Other languages
English (en)
Other versions
JPS622585B2 (ja
Inventor
Kinji Iizuka
Kenji Akaha
Yukio Kamijo
Denichi Momose
Yukiyoshi Ajisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Ono Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd, Ono Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Priority to JP7127378A priority Critical patent/JPS55313A/ja
Priority to CA000329283A priority patent/CA1136634A/en
Priority to GB7920268A priority patent/GB2025946B/en
Priority to IT49367/79A priority patent/IT1162642B/it
Priority to DE19792923815 priority patent/DE2923815A1/de
Priority to FR7915130A priority patent/FR2428632A1/fr
Priority to US06/048,112 priority patent/US4226878A/en
Priority to CH5544/79A priority patent/CH649537A5/de
Publication of JPS55313A publication Critical patent/JPS55313A/ja
Priority to FR8213351A priority patent/FR2517303B1/fr
Publication of JPS622585B2 publication Critical patent/JPS622585B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
JP7127378A 1978-06-13 1978-06-13 Imidazole derivative Granted JPS55313A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP7127378A JPS55313A (en) 1978-06-13 1978-06-13 Imidazole derivative
CA000329283A CA1136634A (en) 1978-06-13 1979-06-07 Process for production of imidazole derivatives
GB7920268A GB2025946B (en) 1978-06-13 1979-06-11 Imidazole derivative
IT49367/79A IT1162642B (it) 1978-06-13 1979-06-11 Derivati di imidazolo composizioni farmaceutiche che li contengono e relativo procedimento di applicazione
DE19792923815 DE2923815A1 (de) 1978-06-13 1979-06-12 Neue imidazolderivate und sie enthaltende pharmazeutische zusammensetzungen
FR7915130A FR2428632A1 (fr) 1978-06-13 1979-06-13 Derives d'imidazole pour le traitement des thromboses
US06/048,112 US4226878A (en) 1978-06-13 1979-06-13 Imidazole derivative
CH5544/79A CH649537A5 (de) 1978-06-13 1979-06-13 Imidazolderivate.
FR8213351A FR2517303B1 (fr) 1978-06-13 1982-07-30 Derives d'imidazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7127378A JPS55313A (en) 1978-06-13 1978-06-13 Imidazole derivative

Publications (2)

Publication Number Publication Date
JPS55313A true JPS55313A (en) 1980-01-05
JPS622585B2 JPS622585B2 (ja) 1987-01-20

Family

ID=13455935

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7127378A Granted JPS55313A (en) 1978-06-13 1978-06-13 Imidazole derivative

Country Status (8)

Country Link
US (1) US4226878A (ja)
JP (1) JPS55313A (ja)
CA (1) CA1136634A (ja)
CH (1) CH649537A5 (ja)
DE (1) DE2923815A1 (ja)
FR (2) FR2428632A1 (ja)
GB (1) GB2025946B (ja)
IT (1) IT1162642B (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57120571U (ja) * 1981-01-16 1982-07-27
JPS57131769A (en) * 1981-02-10 1982-08-14 Kissei Pharmaceut Co Ltd 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate, its preparation and drug containing the same
WO2007023877A1 (ja) * 2005-08-24 2007-03-01 Teika Pharmaceutical Co., Ltd. 角膜疾患治療剤
WO2011059053A1 (ja) 2009-11-13 2011-05-19 東レ株式会社 糖尿病の治療または予防薬

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425354A (en) 1977-08-26 1984-01-10 Burroughs Wellcome Co. Imidazole derivatives and salts thereof, their synthesis, and intermediates, and pharmaceutical formulations
GB2010813B (en) * 1977-10-19 1982-07-28 Wellcome Found Imidazole derivatives and salts thereof their synthesis and intermediates and pharmaceutical formulations
US4405634A (en) * 1977-10-19 1983-09-20 Burroughs Wellcome Co. Imidazole derivatives for treating myocardial infarction
DK157860C (da) * 1979-06-07 1990-07-30 Shionogi & Co Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf
US4430445A (en) 1979-07-19 1984-02-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel basic imidazolylmethylstyrene compound, its polymer, a process for the preparation thereof and a use as ion exchange resin
JPS5756464A (en) * 1980-09-22 1982-04-05 Ono Pharmaceut Co Ltd Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2
JPS6036427B2 (ja) * 1980-12-05 1985-08-20 塩野義製薬株式会社 １−ベンジルイミダゾ−ル誘導体
US4444775A (en) * 1981-06-22 1984-04-24 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridines
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
JPS5855466A (ja) * 1981-09-28 1983-04-01 Kissei Pharmaceut Co Ltd 新規な１，３−二置換イミダゾ−ル誘導体及びその製造方法
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
ES8503669A1 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
IL69487A (en) * 1982-08-14 1987-01-30 Wellcome Found Imidazole derivatives,their preparation and pharmaceutical compositions containing them
US4701343A (en) * 1982-09-24 1987-10-20 Energy Conversion Devices, Inc. Method of depositing thin films using microwave energy
US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
US4470986A (en) * 1982-12-21 1984-09-11 Ciba-Geigy Corporation Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
DE3306196A1 (de) * 1983-02-23 1984-08-23 A. Nattermann & Cie GmbH, 5000 Köln Verfahren zur herstellung von imidazolylbenzaldehyden
DE3306195A1 (de) * 1983-02-23 1984-08-23 A. Nattermann & Cie GmbH, 5000 Köln Verfahren zur herstellung von 6-(4-(1-imidazolyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazinen
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
US4562199A (en) * 1983-08-11 1985-12-31 Thorogood Peter B Imidazole derivatives, compositions and use
US4795657A (en) * 1984-04-13 1989-01-03 Energy Conversion Devices, Inc. Method of fabricating a programmable array
DE3424944A1 (de) * 1984-07-06 1986-02-06 Hoechst Ag, 6230 Frankfurt Neue imidazolyverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3606105A1 (de) * 1986-02-26 1987-08-27 Nattermann A & Cie Verfahren zur herstellung von imidazolyl-thiophenaldehyden
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
EP0239306B1 (en) 1986-03-27 1993-06-02 Merck Frosst Canada Inc. Tetrahydrocarbazole esters
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4837333A (en) * 1987-05-14 1989-06-06 G. D. Searle & Co. Substituted alkylidene imidazoles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
US4851526A (en) * 1987-09-04 1989-07-25 Schering A.G. 1-(4-Substituted phenyl)-1H-imidazoles compounds
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
EP0733366B1 (en) * 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5177089A (en) * 1988-06-01 1993-01-05 Eisai Co., Ltd. Butenoic or propenoic acid derivative
FI892362A (fi) * 1988-06-01 1989-12-02 Eisai Co Ltd Buten- eller propensyraderivat.
JP2753498B2 (ja) * 1988-07-22 1998-05-20 山九株式会社 吊上げ機用のフック装置
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
JP2568315B2 (ja) 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
JP2542274B2 (ja) * 1990-06-08 1996-10-09 富士レビオ株式会社 ３―［４―（１―イミダゾリルメチル）フェニル］―２―プロペン―１―アル及びその製造方法
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
DE4220983A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate
US5359073A (en) * 1992-11-24 1994-10-25 G. D. Searle & Co. Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists
TW259786B (ja) * 1992-12-17 1995-10-11 Sankyo Co
US5262426A (en) * 1993-01-22 1993-11-16 G. D. Searle & Co. N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine compounds as PAF antagonists
US5360907A (en) * 1993-06-14 1994-11-01 G.D. Searle & Co. Pyrrolo[3,2-B]pyridinylalkyl benzamide derivatives
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
EP2234608A2 (en) 2007-12-11 2010-10-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN106432189A (zh) * 2016-09-21 2017-02-22 安徽省逸欣铭医药科技有限公司 苯丙烯酰胺衍生物及其制备方法和医药用途
CN115557898A (zh) * 2021-07-01 2023-01-03 诸葛国琴 一种咪唑类化合物、其中间体及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6574940D0 (pt) * 1964-11-27 1973-08-07 Merck & Co Inc Processo para fazer acidos fenil-aceticos
DE1542690C3 (de) * 1965-07-22 1981-08-20 Basf Ag, 6700 Ludwigshafen Verwendung von Imidazolderivaten als Insektizidsynergisten
US4085209A (en) * 1975-02-05 1978-04-18 Rohm And Haas Company Preparation and safening effect of 1-substituted imidazole metal salt complexes
IE47749B1 (en) * 1977-10-19 1984-06-13 Wellcome Found Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57120571U (ja) * 1981-01-16 1982-07-27
JPS6040541Y2 (ja) * 1981-01-16 1985-12-06 株式会社東芝 エスカレ−タ等の欄干
JPS57131769A (en) * 1981-02-10 1982-08-14 Kissei Pharmaceut Co Ltd 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate, its preparation and drug containing the same
JPH0234941B2 (ja) * 1981-02-10 1990-08-07 Kitsusei Yakuhin Kogyo Kk
WO2007023877A1 (ja) * 2005-08-24 2007-03-01 Teika Pharmaceutical Co., Ltd. 角膜疾患治療剤
US8318739B2 (en) 2005-08-24 2012-11-27 Teika Pharmaceutical Co., Ltd. Remedy for corneal diseases
WO2011059053A1 (ja) 2009-11-13 2011-05-19 東レ株式会社 糖尿病の治療または予防薬
US9492422B2 (en) 2009-11-13 2016-11-15 Toray Industries, Inc. Therapeutic or prophylactic agent for diabetes

Also Published As

Publication number Publication date
FR2428632A1 (fr) 1980-01-11
GB2025946A (en) 1980-01-30
FR2428632B1 (ja) 1983-07-01
GB2025946B (en) 1982-12-08
FR2517303A1 (fr) 1983-06-03
DE2923815C2 (ja) 1989-11-23
IT7949367A0 (it) 1979-06-11
IT1162642B (it) 1987-04-01
CA1136634A (en) 1982-11-30
FR2517303B1 (fr) 1986-03-28
CH649537A5 (de) 1985-05-31
US4226878A (en) 1980-10-07
DE2923815A1 (de) 1980-01-10
JPS622585B2 (ja) 1987-01-20

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