FR2428632A1 - Derives d'imidazole pour le traitement des thromboses - Google Patents

Derives d'imidazole pour le traitement des thromboses

Info

Publication number
FR2428632A1
FR2428632A1 FR7915130A FR7915130A FR2428632A1 FR 2428632 A1 FR2428632 A1 FR 2428632A1 FR 7915130 A FR7915130 A FR 7915130A FR 7915130 A FR7915130 A FR 7915130A FR 2428632 A1 FR2428632 A1 FR 2428632A1
Authority
FR
France
Prior art keywords
thromboses
treatment
imidazole derivatives
substituted
phenylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7915130A
Other languages
English (en)
Other versions
FR2428632B1 (fr
Inventor
Kinji Iizuka
Kenji Akahane
Yukio Kamijo
Denichi Momose
Yukiyoshi Ajisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Publication of FR2428632A1 publication Critical patent/FR2428632A1/fr
Application granted granted Critical
Publication of FR2428632B1 publication Critical patent/FR2428632B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention se rapporte à des N-(alcoyl- omega -substitués-phénylalcoyl) imidazoles, des N-alcoyl- omega -substitué phényl)-imidazoles et des N-(phénylalcoyl)-imidazole substitués sur le phényle. Ce composé est de formule générale :
FR7915130A 1978-06-13 1979-06-13 Derives d'imidazole pour le traitement des thromboses Granted FR2428632A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7127378A JPS55313A (en) 1978-06-13 1978-06-13 Imidazole derivative

Publications (2)

Publication Number Publication Date
FR2428632A1 true FR2428632A1 (fr) 1980-01-11
FR2428632B1 FR2428632B1 (fr) 1983-07-01

Family

ID=13455935

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7915130A Granted FR2428632A1 (fr) 1978-06-13 1979-06-13 Derives d'imidazole pour le traitement des thromboses
FR8213351A Expired FR2517303B1 (fr) 1978-06-13 1982-07-30 Derives d'imidazole

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8213351A Expired FR2517303B1 (fr) 1978-06-13 1982-07-30 Derives d'imidazole

Country Status (8)

Country Link
US (1) US4226878A (fr)
JP (1) JPS55313A (fr)
CA (1) CA1136634A (fr)
CH (1) CH649537A5 (fr)
DE (1) DE2923815A1 (fr)
FR (2) FR2428632A1 (fr)
GB (1) GB2025946B (fr)
IT (1) IT1162642B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495614A1 (fr) * 1980-12-05 1982-06-11 Shionogi & Co Procede de preparation de composes de 1-benzylimidazole, nouveaux produits ainsi obtenus et leur utilisation comme fongicides et pour le traitement antimycose des etres humains ou des animaux
EP0234350A2 (fr) * 1986-02-26 1987-09-02 A. Nattermann & Cie. GmbH Procédé pour la préparation d'aldehydes d'imidazolylthiophène
EP0340153A1 (fr) * 1988-03-31 1989-11-02 Schering Aktiengesellschaft Imidazoles N-substitués, procédé de leur préparation et leur utilisation en médicaments
EP0344577A2 (fr) * 1988-06-01 1989-12-06 Eisai Co., Ltd. Dérivés d'acide buténoique ou propénoique
US5177089A (en) * 1988-06-01 1993-01-05 Eisai Co., Ltd. Butenoic or propenoic acid derivative

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425354A (en) 1977-08-26 1984-01-10 Burroughs Wellcome Co. Imidazole derivatives and salts thereof, their synthesis, and intermediates, and pharmaceutical formulations
GB2010813B (en) * 1977-10-19 1982-07-28 Wellcome Found Imidazole derivatives and salts thereof their synthesis and intermediates and pharmaceutical formulations
US4405634A (en) * 1977-10-19 1983-09-20 Burroughs Wellcome Co. Imidazole derivatives for treating myocardial infarction
DK157860C (da) * 1979-06-07 1990-07-30 Shionogi & Co Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf
US4430445A (en) 1979-07-19 1984-02-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel basic imidazolylmethylstyrene compound, its polymer, a process for the preparation thereof and a use as ion exchange resin
JPS5756464A (en) * 1980-09-22 1982-04-05 Ono Pharmaceut Co Ltd Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2
JPS6040541Y2 (ja) * 1981-01-16 1985-12-06 株式会社東芝 エスカレ−タ等の欄干
JPS57131769A (en) * 1981-02-10 1982-08-14 Kissei Pharmaceut Co Ltd 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate, its preparation and drug containing the same
US4444775A (en) * 1981-06-22 1984-04-24 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridines
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
JPS5855466A (ja) * 1981-09-28 1983-04-01 Kissei Pharmaceut Co Ltd 新規な１，３−二置換イミダゾ−ル誘導体及びその製造方法
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
NZ205247A (en) * 1982-08-14 1987-03-31 Wellcome Found Imidazoles and pharmaceutical compositions
US4701343A (en) * 1982-09-24 1987-10-20 Energy Conversion Devices, Inc. Method of depositing thin films using microwave energy
US4470986A (en) * 1982-12-21 1984-09-11 Ciba-Geigy Corporation Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
DE3306196A1 (de) * 1983-02-23 1984-08-23 A. Nattermann & Cie GmbH, 5000 Köln Verfahren zur herstellung von imidazolylbenzaldehyden
DE3306195A1 (de) * 1983-02-23 1984-08-23 A. Nattermann & Cie GmbH, 5000 Köln Verfahren zur herstellung von 6-(4-(1-imidazolyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazinen
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
US4562199A (en) * 1983-08-11 1985-12-31 Thorogood Peter B Imidazole derivatives, compositions and use
US4795657A (en) * 1984-04-13 1989-01-03 Energy Conversion Devices, Inc. Method of fabricating a programmable array
DE3424944A1 (de) * 1984-07-06 1986-02-06 Hoechst Ag, 6230 Frankfurt Neue imidazolyverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
DE3786030T2 (de) 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole Ester.
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4837333A (en) * 1987-05-14 1989-06-06 G. D. Searle & Co. Substituted alkylidene imidazoles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
US4851526A (en) * 1987-09-04 1989-07-25 Schering A.G. 1-(4-Substituted phenyl)-1H-imidazoles compounds
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
EP0733366B1 (fr) * 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Compositions pharmaceutiques comprenant des imidazoles comme antagonistes d'angiotensine II et des diurétiques
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
CA1338238C (fr) 1988-01-07 1996-04-09 David John Carini Imidazoles bloquant les recepteurs de l'angiotensine ii et combinaisons de ces imidazoles avec des diuretiques et des anti-inflammatoires non steroidiens
JP2753498B2 (ja) * 1988-07-22 1998-05-20 山九株式会社 吊上げ機用のフック装置
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
WO1991000281A2 (fr) 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Imidazoles a substitution aryle a anneau fusionne
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
JP2542274B2 (ja) * 1990-06-08 1996-10-09 富士レビオ株式会社 ３―［４―（１―イミダゾリルメチル）フェニル］―２―プロペン―１―アル及びその製造方法
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
DE4220983A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate
US5359073A (en) * 1992-11-24 1994-10-25 G. D. Searle & Co. Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists
RU2109736C1 (ru) * 1992-12-17 1998-04-27 Санкио Компани Лимитед Производные бифенила и способ их получения
US5262426A (en) * 1993-01-22 1993-11-16 G. D. Searle & Co. N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine compounds as PAF antagonists
US5360907A (en) * 1993-06-14 1994-11-01 G.D. Searle & Co. Pyrrolo[3,2-B]pyridinylalkyl benzamide derivatives
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
JP4778515B2 (ja) 2005-08-24 2011-09-21 テイカ製薬株式会社 角膜疾患治療剤
WO2009105140A2 (fr) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Inhibiteurs de métalloenzymes utilisant des fractions de liaison à un métal en combinaison avec des fractions de ciblage
WO2011059053A1 (fr) 2009-11-13 2011-05-19 東レ株式会社 Agent de traitement ou de prévention du diabète
CN106432189A (zh) * 2016-09-21 2017-02-22 安徽省逸欣铭医药科技有限公司 苯丙烯酰胺衍生物及其制备方法和医药用途
WO2023274257A1 (fr) * 2021-07-01 2023-01-05 诸葛国琴 Composé imidazole et intermédiaire et leur utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2299807A1 (fr) * 1975-02-05 1976-09-03 Rohm & Haas Produits et composit
DE2845406A1 (de) * 1977-10-19 1979-05-03 Wellcome Found 1-arylalkylimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende formulierungen
FR2416012A1 (fr) * 1978-02-01 1979-08-31 Wellcome Found Derives de l'imidazole et medicament contenant ces substances

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6574940D0 (pt) * 1964-11-27 1973-08-07 Merck & Co Inc Processo para fazer acidos fenil-aceticos
DE1542690C3 (de) * 1965-07-22 1981-08-20 Basf Ag, 6700 Ludwigshafen Verwendung von Imidazolderivaten als Insektizidsynergisten

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2299807A1 (fr) * 1975-02-05 1976-09-03 Rohm & Haas Produits et composit
DE2845406A1 (de) * 1977-10-19 1979-05-03 Wellcome Found 1-arylalkylimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende formulierungen
FR2416012A1 (fr) * 1978-02-01 1979-08-31 Wellcome Found Derives de l'imidazole et medicament contenant ces substances

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495614A1 (fr) * 1980-12-05 1982-06-11 Shionogi & Co Procede de preparation de composes de 1-benzylimidazole, nouveaux produits ainsi obtenus et leur utilisation comme fongicides et pour le traitement antimycose des etres humains ou des animaux
EP0234350A2 (fr) * 1986-02-26 1987-09-02 A. Nattermann & Cie. GmbH Procédé pour la préparation d'aldehydes d'imidazolylthiophène
EP0234350A3 (fr) * 1986-02-26 1989-07-05 A. Nattermann & Cie. GmbH Procédé pour la préparation d'aldehydes d'imidazolylthiophène
EP0340153A1 (fr) * 1988-03-31 1989-11-02 Schering Aktiengesellschaft Imidazoles N-substitués, procédé de leur préparation et leur utilisation en médicaments
EP0344577A2 (fr) * 1988-06-01 1989-12-06 Eisai Co., Ltd. Dérivés d'acide buténoique ou propénoique
EP0344577A3 (fr) * 1988-06-01 1992-03-25 Eisai Co., Ltd. Dérivés d'acide buténoique ou propénoique
US5177089A (en) * 1988-06-01 1993-01-05 Eisai Co., Ltd. Butenoic or propenoic acid derivative
US5607953A (en) * 1988-06-01 1997-03-04 Eisai Co., Ltd. Butenoic or propenoic acid derivative

Also Published As

Publication number Publication date
JPS622585B2 (fr) 1987-01-20
GB2025946A (en) 1980-01-30
CA1136634A (fr) 1982-11-30
FR2428632B1 (fr) 1983-07-01
IT7949367A0 (it) 1979-06-11
CH649537A5 (de) 1985-05-31
IT1162642B (it) 1987-04-01
US4226878A (en) 1980-10-07
DE2923815C2 (fr) 1989-11-23
GB2025946B (en) 1982-12-08
FR2517303A1 (fr) 1983-06-03
JPS55313A (en) 1980-01-05
FR2517303B1 (fr) 1986-03-28
DE2923815A1 (de) 1980-01-10

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