JPS55139369A - Preparation of 1,4-di-substituted piperazine - Google Patents
Preparation of 1,4-di-substituted piperazineInfo
- Publication number
- JPS55139369A JPS55139369A JP4427779A JP4427779A JPS55139369A JP S55139369 A JPS55139369 A JP S55139369A JP 4427779 A JP4427779 A JP 4427779A JP 4427779 A JP4427779 A JP 4427779A JP S55139369 A JPS55139369 A JP S55139369A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkali metal
- cyclopropiophenone
- reacting
- hydrogen halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound by reacting 1-(2-phenyl-2-alkoxyethyl)- piperazine, etc. with cyclopropiophenone in the presence of an alkali metal sulfite, a hydrogen halide, and an alkali metal carbonate.
CONSTITUTION: The compound II is prepared by reacting a compound I (R is H or alkyl) with cyclopropiophenone in the presence of an alkali metal sulfite, a hydrogen halide, and an alkali metal carbonate, pref. in water or in an organic solvent (e.g. alcohol, ether, aromatic hydrocarbon, etc.) at a temperature between room temperature and the boiling point of the reaction mixture, for several to 24 hr.
EFFECT: The objective compound can be obtained in high purity and yield, with a simple and economical process.
USE: An antitussive (the compound II wherein R is ethyl, is known as "Eprazinone"), etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4427779A JPS55139369A (en) | 1979-04-13 | 1979-04-13 | Preparation of 1,4-di-substituted piperazine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4427779A JPS55139369A (en) | 1979-04-13 | 1979-04-13 | Preparation of 1,4-di-substituted piperazine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55139369A true JPS55139369A (en) | 1980-10-31 |
Family
ID=12687005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4427779A Pending JPS55139369A (en) | 1979-04-13 | 1979-04-13 | Preparation of 1,4-di-substituted piperazine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55139369A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5422380A (en) * | 1977-07-21 | 1979-02-20 | Asahi Chem Ind Co Ltd | Preparation of substituted pipebrazine |
-
1979
- 1979-04-13 JP JP4427779A patent/JPS55139369A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5422380A (en) * | 1977-07-21 | 1979-02-20 | Asahi Chem Ind Co Ltd | Preparation of substituted pipebrazine |
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