JPS55139369A - Preparation of 1,4-di-substituted piperazine - Google Patents

Preparation of 1,4-di-substituted piperazine

Info

Publication number
JPS55139369A
JPS55139369A JP4427779A JP4427779A JPS55139369A JP S55139369 A JPS55139369 A JP S55139369A JP 4427779 A JP4427779 A JP 4427779A JP 4427779 A JP4427779 A JP 4427779A JP S55139369 A JPS55139369 A JP S55139369A
Authority
JP
Japan
Prior art keywords
compound
alkali metal
cyclopropiophenone
reacting
hydrogen halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4427779A
Other languages
Japanese (ja)
Inventor
Kiyonori Yokogoshi
Kunio Nagata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP4427779A priority Critical patent/JPS55139369A/en
Publication of JPS55139369A publication Critical patent/JPS55139369A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound by reacting 1-(2-phenyl-2-alkoxyethyl)- piperazine, etc. with cyclopropiophenone in the presence of an alkali metal sulfite, a hydrogen halide, and an alkali metal carbonate.
CONSTITUTION: The compound II is prepared by reacting a compound I (R is H or alkyl) with cyclopropiophenone in the presence of an alkali metal sulfite, a hydrogen halide, and an alkali metal carbonate, pref. in water or in an organic solvent (e.g. alcohol, ether, aromatic hydrocarbon, etc.) at a temperature between room temperature and the boiling point of the reaction mixture, for several to 24 hr.
EFFECT: The objective compound can be obtained in high purity and yield, with a simple and economical process.
USE: An antitussive (the compound II wherein R is ethyl, is known as "Eprazinone"), etc.
COPYRIGHT: (C)1980,JPO&Japio
JP4427779A 1979-04-13 1979-04-13 Preparation of 1,4-di-substituted piperazine Pending JPS55139369A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4427779A JPS55139369A (en) 1979-04-13 1979-04-13 Preparation of 1,4-di-substituted piperazine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4427779A JPS55139369A (en) 1979-04-13 1979-04-13 Preparation of 1,4-di-substituted piperazine

Publications (1)

Publication Number Publication Date
JPS55139369A true JPS55139369A (en) 1980-10-31

Family

ID=12687005

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4427779A Pending JPS55139369A (en) 1979-04-13 1979-04-13 Preparation of 1,4-di-substituted piperazine

Country Status (1)

Country Link
JP (1) JPS55139369A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5422380A (en) * 1977-07-21 1979-02-20 Asahi Chem Ind Co Ltd Preparation of substituted pipebrazine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5422380A (en) * 1977-07-21 1979-02-20 Asahi Chem Ind Co Ltd Preparation of substituted pipebrazine

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