JPS5746964A - Novel method of producing 4-benzazonine derivative - Google Patents
Novel method of producing 4-benzazonine derivativeInfo
- Publication number
- JPS5746964A JPS5746964A JP12301980A JP12301980A JPS5746964A JP S5746964 A JPS5746964 A JP S5746964A JP 12301980 A JP12301980 A JP 12301980A JP 12301980 A JP12301980 A JP 12301980A JP S5746964 A JPS5746964 A JP S5746964A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- tetrahydronaphthalene
- hydroxy
- benzazonine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: The ring closure of a tetrahydronaphthalene derivative is conducted in the presence of an acid acceptor to readily produce the titled compound having important pharmacological activities such as analgesic, antitussive and so on under relatively mild conditions with industrial advantage.
CONSTITUTION: A tetrahydronaphthalene derivative of formula I (R1, R2 are H, lower alkyl; R3 is H, hydroxy, alkoxy; one of X and Y is halogen and the other is amino, lower alkylamino) is used as a raw material to effect the cyclization reaction in the presence of an acid acceptor, preferably potassium or sodium carbonate at room temperature to 100°C to produce a compound of formula II (R4 is H, lower alkyl). An example of the starting material of formula I is 1-(2-methylaminoethyl)- 1-methyl-3-bromomethyl-7-hydroxy-1,2,3,4-tetrahydronaphthalene.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12301980A JPS5746964A (en) | 1980-09-05 | 1980-09-05 | Novel method of producing 4-benzazonine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12301980A JPS5746964A (en) | 1980-09-05 | 1980-09-05 | Novel method of producing 4-benzazonine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5746964A true JPS5746964A (en) | 1982-03-17 |
Family
ID=14850206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12301980A Pending JPS5746964A (en) | 1980-09-05 | 1980-09-05 | Novel method of producing 4-benzazonine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5746964A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6316905A (en) * | 1986-07-09 | 1988-01-23 | Satoo Tsukamoto | Four-claw chuck |
US4833244A (en) * | 1985-04-22 | 1989-05-23 | Hoechst-Rouseel Pharmaceuticals Inc. | Ethanobenzazepines |
JPH0537405U (en) * | 1991-10-22 | 1993-05-21 | 豊和工業株式会社 | Power check with drawbar |
-
1980
- 1980-09-05 JP JP12301980A patent/JPS5746964A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4833244A (en) * | 1985-04-22 | 1989-05-23 | Hoechst-Rouseel Pharmaceuticals Inc. | Ethanobenzazepines |
JPS6316905A (en) * | 1986-07-09 | 1988-01-23 | Satoo Tsukamoto | Four-claw chuck |
JPH0217284B2 (en) * | 1986-07-09 | 1990-04-20 | Satoo Tsukamoto | |
JPH0537405U (en) * | 1991-10-22 | 1993-05-21 | 豊和工業株式会社 | Power check with drawbar |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5746964A (en) | Novel method of producing 4-benzazonine derivative | |
JPS57195767A (en) | Novel trisazo compound and production thereof | |
ES8506586A1 (en) | Meta- and para-isopropenyl-alpha,alpha-dimethylbenzylamine. | |
JPS5758662A (en) | Production of o-nitrophenyl-beta-hydroxyethylsulfide | |
JPS5716882A (en) | Production of benzo-heteroring derivative | |
JPS578222A (en) | Production of low terminal-carboxyl content polyester | |
ES456325A1 (en) | Quinoline carboxalic acid esters | |
JPS52100473A (en) | Novel azimidebenzamide derivative and its production | |
JPS5742689A (en) | Novel indole derivative and its preparation | |
JPS55111468A (en) | Preparation of n-benzyl-tetrahydro isoquinoline derivative | |
JPS5759883A (en) | Production of chromone-3-carboxylic acid | |
JPS57144253A (en) | Preparation of crude aminoalkylthiol | |
JPS5473797A (en) | Pyride 3.2.1-jk carbazole derivative | |
JPS51125239A (en) | Process for preparing new bytyrophenone derivatives | |
JPS55105682A (en) | Production of thienylimidazoles | |
JPS5639064A (en) | Preparation of substance sf-1836 and intermediate of substance sf-1836 | |
JPS54128599A (en) | Pyrrolobenzazepin derivative | |
JPS55127331A (en) | Preparation of 4-methyl-2,4-bis(p-substituted-oxyphenyl) pent-1-ene | |
JPS57169480A (en) | Production of indole derivative | |
JPS5618971A (en) | Alpha-halogeno-beta-benzosulfimidopropionitrile and its preparation | |
JPS5663981A (en) | Flavan derivative and its acid addition salt | |
JPS5620556A (en) | Production of alpha-halogeno-beta-alanine | |
JPS56152470A (en) | Production of 2-benzothiazolinone derivative | |
JPS5683473A (en) | Cyclopent b indole derivative | |
JPS56133249A (en) | Production of amine |