JPS5746964A - Novel method of producing 4-benzazonine derivative - Google Patents

Novel method of producing 4-benzazonine derivative

Info

Publication number
JPS5746964A
JPS5746964A JP12301980A JP12301980A JPS5746964A JP S5746964 A JPS5746964 A JP S5746964A JP 12301980 A JP12301980 A JP 12301980A JP 12301980 A JP12301980 A JP 12301980A JP S5746964 A JPS5746964 A JP S5746964A
Authority
JP
Japan
Prior art keywords
formula
derivative
tetrahydronaphthalene
hydroxy
benzazonine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12301980A
Other languages
Japanese (ja)
Inventor
Osamu Futsukaichi
Ichihiro Hayashi
Yoshio Miyamura
Keiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Iyakuhin Kogyo Co Ltd
Original Assignee
Nihon Iyakuhin Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Iyakuhin Kogyo Co Ltd filed Critical Nihon Iyakuhin Kogyo Co Ltd
Priority to JP12301980A priority Critical patent/JPS5746964A/en
Publication of JPS5746964A publication Critical patent/JPS5746964A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: The ring closure of a tetrahydronaphthalene derivative is conducted in the presence of an acid acceptor to readily produce the titled compound having important pharmacological activities such as analgesic, antitussive and so on under relatively mild conditions with industrial advantage.
CONSTITUTION: A tetrahydronaphthalene derivative of formula I (R1, R2 are H, lower alkyl; R3 is H, hydroxy, alkoxy; one of X and Y is halogen and the other is amino, lower alkylamino) is used as a raw material to effect the cyclization reaction in the presence of an acid acceptor, preferably potassium or sodium carbonate at room temperature to 100°C to produce a compound of formula II (R4 is H, lower alkyl). An example of the starting material of formula I is 1-(2-methylaminoethyl)- 1-methyl-3-bromomethyl-7-hydroxy-1,2,3,4-tetrahydronaphthalene.
COPYRIGHT: (C)1982,JPO&Japio
JP12301980A 1980-09-05 1980-09-05 Novel method of producing 4-benzazonine derivative Pending JPS5746964A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12301980A JPS5746964A (en) 1980-09-05 1980-09-05 Novel method of producing 4-benzazonine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12301980A JPS5746964A (en) 1980-09-05 1980-09-05 Novel method of producing 4-benzazonine derivative

Publications (1)

Publication Number Publication Date
JPS5746964A true JPS5746964A (en) 1982-03-17

Family

ID=14850206

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12301980A Pending JPS5746964A (en) 1980-09-05 1980-09-05 Novel method of producing 4-benzazonine derivative

Country Status (1)

Country Link
JP (1) JPS5746964A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6316905A (en) * 1986-07-09 1988-01-23 Satoo Tsukamoto Four-claw chuck
US4833244A (en) * 1985-04-22 1989-05-23 Hoechst-Rouseel Pharmaceuticals Inc. Ethanobenzazepines
JPH0537405U (en) * 1991-10-22 1993-05-21 豊和工業株式会社 Power check with drawbar

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833244A (en) * 1985-04-22 1989-05-23 Hoechst-Rouseel Pharmaceuticals Inc. Ethanobenzazepines
JPS6316905A (en) * 1986-07-09 1988-01-23 Satoo Tsukamoto Four-claw chuck
JPH0217284B2 (en) * 1986-07-09 1990-04-20 Satoo Tsukamoto
JPH0537405U (en) * 1991-10-22 1993-05-21 豊和工業株式会社 Power check with drawbar

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