JPS55105682A - Production of thienylimidazoles - Google Patents

Production of thienylimidazoles

Info

Publication number
JPS55105682A
JPS55105682A JP15216879A JP15216879A JPS55105682A JP S55105682 A JPS55105682 A JP S55105682A JP 15216879 A JP15216879 A JP 15216879A JP 15216879 A JP15216879 A JP 15216879A JP S55105682 A JPS55105682 A JP S55105682A
Authority
JP
Japan
Prior art keywords
compound
formula
halogen
lower alkyl
organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15216879A
Other languages
Japanese (ja)
Other versions
JPS5713550B2 (en
Inventor
Kazuhiko Araki
Tetsuya Tawara
Masami Shiraki
Hideo Matsuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP15216879A priority Critical patent/JPS55105682A/en
Publication of JPS55105682A publication Critical patent/JPS55105682A/en
Publication of JPS5713550B2 publication Critical patent/JPS5713550B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: A specific thienodiazepin is hydrolyzed and the product is made to react with a nitrite salt, when necessary, further subjected to organic sulfonylation to give a thienylimidazole, an intermediate of tranquillizer, hypnotic and others.
CONSTITUTION: The compound of formula I (R1WR4 are H, lower alkyl, or R1 and R2 may incorporate to form 3W5C alkylene; R is H, halogen) is hydrolyzed in the presence of a hydrohalogenic acid. Then, an alkali metal nitrite is added to the reaction mixture and the reaction is effected at room temperature or with heat to give the compound of formula II (Z is halogen, hydroxyl). Or the compound of formula II with Z of hydroxyl group is subjected to halogenation or organic sulfonylation and converted to the compound of formula II with Z of halogen or organic sulfonyl. The compound of formula II is useful as a synthetic intermediate of the compound of formula III (R5 is lower alkyl; R6 is H, lower alkyl) that is useful as medicine.
COPYRIGHT: (C)1980,JPO&Japio
JP15216879A 1979-11-24 1979-11-24 Production of thienylimidazoles Granted JPS55105682A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15216879A JPS55105682A (en) 1979-11-24 1979-11-24 Production of thienylimidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15216879A JPS55105682A (en) 1979-11-24 1979-11-24 Production of thienylimidazoles

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP9333772A Division JPS5521750B2 (en) 1972-08-08 1972-09-16

Publications (2)

Publication Number Publication Date
JPS55105682A true JPS55105682A (en) 1980-08-13
JPS5713550B2 JPS5713550B2 (en) 1982-03-17

Family

ID=15534511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15216879A Granted JPS55105682A (en) 1979-11-24 1979-11-24 Production of thienylimidazoles

Country Status (1)

Country Link
JP (1) JPS55105682A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01294676A (en) * 1988-05-23 1989-11-28 Yoshitomi Pharmaceut Ind Ltd Thienylazole compound
US5760032A (en) * 1994-06-01 1998-06-02 Yoshitomi Pharmaceutical Industries, Ltd. Thienylazole compound and thienotriazolodiazepine compound

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01294676A (en) * 1988-05-23 1989-11-28 Yoshitomi Pharmaceut Ind Ltd Thienylazole compound
US5760032A (en) * 1994-06-01 1998-06-02 Yoshitomi Pharmaceutical Industries, Ltd. Thienylazole compound and thienotriazolodiazepine compound

Also Published As

Publication number Publication date
JPS5713550B2 (en) 1982-03-17

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