JPS55105682A - Production of thienylimidazoles - Google Patents
Production of thienylimidazolesInfo
- Publication number
- JPS55105682A JPS55105682A JP15216879A JP15216879A JPS55105682A JP S55105682 A JPS55105682 A JP S55105682A JP 15216879 A JP15216879 A JP 15216879A JP 15216879 A JP15216879 A JP 15216879A JP S55105682 A JPS55105682 A JP S55105682A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- halogen
- lower alkyl
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: A specific thienodiazepin is hydrolyzed and the product is made to react with a nitrite salt, when necessary, further subjected to organic sulfonylation to give a thienylimidazole, an intermediate of tranquillizer, hypnotic and others.
CONSTITUTION: The compound of formula I (R1WR4 are H, lower alkyl, or R1 and R2 may incorporate to form 3W5C alkylene; R is H, halogen) is hydrolyzed in the presence of a hydrohalogenic acid. Then, an alkali metal nitrite is added to the reaction mixture and the reaction is effected at room temperature or with heat to give the compound of formula II (Z is halogen, hydroxyl). Or the compound of formula II with Z of hydroxyl group is subjected to halogenation or organic sulfonylation and converted to the compound of formula II with Z of halogen or organic sulfonyl. The compound of formula II is useful as a synthetic intermediate of the compound of formula III (R5 is lower alkyl; R6 is H, lower alkyl) that is useful as medicine.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15216879A JPS55105682A (en) | 1979-11-24 | 1979-11-24 | Production of thienylimidazoles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15216879A JPS55105682A (en) | 1979-11-24 | 1979-11-24 | Production of thienylimidazoles |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9333772A Division JPS5521750B2 (en) | 1972-08-08 | 1972-09-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55105682A true JPS55105682A (en) | 1980-08-13 |
JPS5713550B2 JPS5713550B2 (en) | 1982-03-17 |
Family
ID=15534511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15216879A Granted JPS55105682A (en) | 1979-11-24 | 1979-11-24 | Production of thienylimidazoles |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55105682A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01294676A (en) * | 1988-05-23 | 1989-11-28 | Yoshitomi Pharmaceut Ind Ltd | Thienylazole compound |
US5760032A (en) * | 1994-06-01 | 1998-06-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienylazole compound and thienotriazolodiazepine compound |
-
1979
- 1979-11-24 JP JP15216879A patent/JPS55105682A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01294676A (en) * | 1988-05-23 | 1989-11-28 | Yoshitomi Pharmaceut Ind Ltd | Thienylazole compound |
US5760032A (en) * | 1994-06-01 | 1998-06-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienylazole compound and thienotriazolodiazepine compound |
Also Published As
Publication number | Publication date |
---|---|
JPS5713550B2 (en) | 1982-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55105682A (en) | Production of thienylimidazoles | |
JPS55105681A (en) | Production of novel thienyltriazoles | |
JPS5785338A (en) | Fluoromalonic acid derivative and its production | |
JPS5655383A (en) | Amizine derivative and its preparation | |
JPS5753469A (en) | 5-fluorouracil derivative, its preparation and use | |
JPS5683428A (en) | Preparation of 2-substituted resorcinol | |
JPS5746964A (en) | Novel method of producing 4-benzazonine derivative | |
JPS5625166A (en) | 5-fluorouracil derivative | |
JPS55124781A (en) | 1,4-benzdioxanesulfonamide derivative | |
JPS55111468A (en) | Preparation of n-benzyl-tetrahydro isoquinoline derivative | |
JPS5618971A (en) | Alpha-halogeno-beta-benzosulfimidopropionitrile and its preparation | |
JPS5547651A (en) | Production of sulfoxyimine | |
JPS5649398A (en) | Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine | |
JPS5777644A (en) | Liquid crystal ester compound | |
JPS57179174A (en) | Novel aminocyclitol and its preparation | |
JPS5798237A (en) | Novel 2,3-dihydro-indene derivative | |
JPS5547652A (en) | Production of substituted sulfondiimine | |
JPS57171983A (en) | Aminophenyltetrazole derivative and salt thereof | |
JPS57193444A (en) | Sulfonate derivative, its preparation and antilipemic agent containing the same | |
JPS5513226A (en) | Production of beta-(beta-chloroethylsulfonyl) propionic acid derivative | |
JPS577466A (en) | Preparation of indole derivative | |
JPS55145699A (en) | Steroid double salt effective for chemotheraphy | |
JPS5758662A (en) | Production of o-nitrophenyl-beta-hydroxyethylsulfide | |
JPS5643270A (en) | Production of 4-benzoyl-5-hydroxypyrazole | |
JPS5629526A (en) | Preparation of acylcyanide |