JPS5498788A - Preparation of piperazine derivative and its acid addition salt - Google Patents

Preparation of piperazine derivative and its acid addition salt

Info

Publication number
JPS5498788A
JPS5498788A JP196178A JP196178A JPS5498788A JP S5498788 A JPS5498788 A JP S5498788A JP 196178 A JP196178 A JP 196178A JP 196178 A JP196178 A JP 196178A JP S5498788 A JPS5498788 A JP S5498788A
Authority
JP
Japan
Prior art keywords
formula
derivative
piperazine derivative
acid addition
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP196178A
Other languages
Japanese (ja)
Other versions
JPS6034549B2 (en
Inventor
Butsushiyu Norubeeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP53001961A priority Critical patent/JPS6034549B2/en
Publication of JPS5498788A publication Critical patent/JPS5498788A/en
Publication of JPS6034549B2 publication Critical patent/JPS6034549B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To obtain a piperazine derivative and its acid addition salt having an antitussive action, e.g. Eprazinon, by reacting a piperazine derivative with a propiophenone derivative.
CONSTITUTION: A piperazine derivative of formula I: (R is lower alkyl group) is reacted with a propiophenone derivative of formula II: (A is tertiary amino group which may be removed easily in reaction with the compound of formula I) in the presence of an organic solvent, e.g. benzene or toluene, at a temperature around the boiling point for 3W20 hr to give a compound of formula III. The compound of formula I is obtained by reacting a 2-phenyl-2-alkoxyethyl bromide with anhydrous piperazine under heating and refluxing.
COPYRIGHT: (C)1979,JPO&Japio
JP53001961A 1978-01-13 1978-01-13 Method for producing piperazine derivatives and acid addition salts thereof Expired JPS6034549B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53001961A JPS6034549B2 (en) 1978-01-13 1978-01-13 Method for producing piperazine derivatives and acid addition salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53001961A JPS6034549B2 (en) 1978-01-13 1978-01-13 Method for producing piperazine derivatives and acid addition salts thereof

Publications (2)

Publication Number Publication Date
JPS5498788A true JPS5498788A (en) 1979-08-03
JPS6034549B2 JPS6034549B2 (en) 1985-08-09

Family

ID=11516176

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53001961A Expired JPS6034549B2 (en) 1978-01-13 1978-01-13 Method for producing piperazine derivatives and acid addition salts thereof

Country Status (1)

Country Link
JP (1) JPS6034549B2 (en)

Also Published As

Publication number Publication date
JPS6034549B2 (en) 1985-08-09

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