JPS5498788A - Preparation of piperazine derivative and its acid addition salt - Google Patents
Preparation of piperazine derivative and its acid addition saltInfo
- Publication number
- JPS5498788A JPS5498788A JP196178A JP196178A JPS5498788A JP S5498788 A JPS5498788 A JP S5498788A JP 196178 A JP196178 A JP 196178A JP 196178 A JP196178 A JP 196178A JP S5498788 A JPS5498788 A JP S5498788A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- piperazine derivative
- acid addition
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain a piperazine derivative and its acid addition salt having an antitussive action, e.g. Eprazinon, by reacting a piperazine derivative with a propiophenone derivative.
CONSTITUTION: A piperazine derivative of formula I: (R is lower alkyl group) is reacted with a propiophenone derivative of formula II: (A is tertiary amino group which may be removed easily in reaction with the compound of formula I) in the presence of an organic solvent, e.g. benzene or toluene, at a temperature around the boiling point for 3W20 hr to give a compound of formula III. The compound of formula I is obtained by reacting a 2-phenyl-2-alkoxyethyl bromide with anhydrous piperazine under heating and refluxing.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53001961A JPS6034549B2 (en) | 1978-01-13 | 1978-01-13 | Method for producing piperazine derivatives and acid addition salts thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53001961A JPS6034549B2 (en) | 1978-01-13 | 1978-01-13 | Method for producing piperazine derivatives and acid addition salts thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5498788A true JPS5498788A (en) | 1979-08-03 |
JPS6034549B2 JPS6034549B2 (en) | 1985-08-09 |
Family
ID=11516176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53001961A Expired JPS6034549B2 (en) | 1978-01-13 | 1978-01-13 | Method for producing piperazine derivatives and acid addition salts thereof |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6034549B2 (en) |
-
1978
- 1978-01-13 JP JP53001961A patent/JPS6034549B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6034549B2 (en) | 1985-08-09 |
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