JPS55115863A - Guanidinobenzoic acid derivative and its preparation - Google Patents

Guanidinobenzoic acid derivative and its preparation

Info

Publication number
JPS55115863A
JPS55115863A JP2257279A JP2257279A JPS55115863A JP S55115863 A JPS55115863 A JP S55115863A JP 2257279 A JP2257279 A JP 2257279A JP 2257279 A JP2257279 A JP 2257279A JP S55115863 A JPS55115863 A JP S55115863A
Authority
JP
Japan
Prior art keywords
formula
compound
acid addition
acid derivative
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2257279A
Other languages
Japanese (ja)
Other versions
JPS6141510B2 (en
Inventor
Setsuo Fujii
Takeshi Watanabe
Seiji Shioda
Itsuo Okumoto
Naohiro Kayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP2257279A priority Critical patent/JPS55115863A/en
Priority to GB8003854A priority patent/GB2044760B/en
Priority to DE19803005580 priority patent/DE3005580A1/en
Priority to US06/123,609 priority patent/US4283418A/en
Priority to FR8004573A priority patent/FR2450251A1/en
Publication of JPS55115863A publication Critical patent/JPS55115863A/en
Publication of JPS6141510B2 publication Critical patent/JPS6141510B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A guanidinobenzoic acid derivative of formula I (Z is carbon- carbon covalent bond; methylene, vinylene, etc.; R1 and R2 are H or lower alkyl groups), or its acid addition salt.
EXAMPLE: p-( p-Guanidinobenzoyloxy )-N, N-dimethyl-phenylacetamido-methanesulfonate.
USE: Remedies for acute pancreatitis, or hemorrhagic diseases as an aptiplasmin, having powerful inhibitory actions against proteolytic enzyme trypsin or plasmin at a low concentration, and high water solubility, usable for administration as an aqueous or physiological salt solution.
PROCESS: An acid addition salt of a compound of formula II (X is halogen) is reacted with a compound of formula III in an inert solvent in the presence of a dehydrohalogenating agent at -20°C to room temperature for 1W5hr to give the title derivative of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP2257279A 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation Granted JPS55115863A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2257279A JPS55115863A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation
GB8003854A GB2044760B (en) 1979-03-01 1980-02-05 Guanidinobenzoic acid derivatives
DE19803005580 DE3005580A1 (en) 1979-03-01 1980-02-14 GUANIDINOBENZOESAE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES
US06/123,609 US4283418A (en) 1979-03-01 1980-02-22 Guanidinobenzoic acid derivatives and process for their preparation
FR8004573A FR2450251A1 (en) 1979-03-01 1980-02-29 GUANIDINOBENZOIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2257279A JPS55115863A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS55115863A true JPS55115863A (en) 1980-09-06
JPS6141510B2 JPS6141510B2 (en) 1986-09-16

Family

ID=12086580

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2257279A Granted JPS55115863A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS55115863A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008546850A (en) * 2006-07-26 2008-12-25 テバ ファーマシューティカル インダストリーズ リミティド Method for synthesizing O-desmethylvenlafaxine
JP2010229141A (en) * 2010-05-19 2010-10-14 Sumitomo Chemical Co Ltd Method for producing camostat hydrochloride
WO2016148135A1 (en) * 2015-03-16 2016-09-22 武田薬品工業株式会社 Therapeutic agent

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02183730A (en) * 1989-01-09 1990-07-18 Sanyo Electric Co Ltd Cooker

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008546850A (en) * 2006-07-26 2008-12-25 テバ ファーマシューティカル インダストリーズ リミティド Method for synthesizing O-desmethylvenlafaxine
JP2010229141A (en) * 2010-05-19 2010-10-14 Sumitomo Chemical Co Ltd Method for producing camostat hydrochloride
WO2016148135A1 (en) * 2015-03-16 2016-09-22 武田薬品工業株式会社 Therapeutic agent

Also Published As

Publication number Publication date
JPS6141510B2 (en) 1986-09-16

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