JPS55115863A - Guanidinobenzoic acid derivative and its preparation - Google Patents
Guanidinobenzoic acid derivative and its preparationInfo
- Publication number
- JPS55115863A JPS55115863A JP2257279A JP2257279A JPS55115863A JP S55115863 A JPS55115863 A JP S55115863A JP 2257279 A JP2257279 A JP 2257279A JP 2257279 A JP2257279 A JP 2257279A JP S55115863 A JPS55115863 A JP S55115863A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- acid addition
- acid derivative
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A guanidinobenzoic acid derivative of formula I (Z is carbon- carbon covalent bond; methylene, vinylene, etc.; R1 and R2 are H or lower alkyl groups), or its acid addition salt.
EXAMPLE: p-( p-Guanidinobenzoyloxy )-N, N-dimethyl-phenylacetamido-methanesulfonate.
USE: Remedies for acute pancreatitis, or hemorrhagic diseases as an aptiplasmin, having powerful inhibitory actions against proteolytic enzyme trypsin or plasmin at a low concentration, and high water solubility, usable for administration as an aqueous or physiological salt solution.
PROCESS: An acid addition salt of a compound of formula II (X is halogen) is reacted with a compound of formula III in an inert solvent in the presence of a dehydrohalogenating agent at -20°C to room temperature for 1W5hr to give the title derivative of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2257279A JPS55115863A (en) | 1979-03-01 | 1979-03-01 | Guanidinobenzoic acid derivative and its preparation |
GB8003854A GB2044760B (en) | 1979-03-01 | 1980-02-05 | Guanidinobenzoic acid derivatives |
DE19803005580 DE3005580A1 (en) | 1979-03-01 | 1980-02-14 | GUANIDINOBENZOESAE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES |
US06/123,609 US4283418A (en) | 1979-03-01 | 1980-02-22 | Guanidinobenzoic acid derivatives and process for their preparation |
FR8004573A FR2450251A1 (en) | 1979-03-01 | 1980-02-29 | GUANIDINOBENZOIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2257279A JPS55115863A (en) | 1979-03-01 | 1979-03-01 | Guanidinobenzoic acid derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55115863A true JPS55115863A (en) | 1980-09-06 |
JPS6141510B2 JPS6141510B2 (en) | 1986-09-16 |
Family
ID=12086580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2257279A Granted JPS55115863A (en) | 1979-03-01 | 1979-03-01 | Guanidinobenzoic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55115863A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008546850A (en) * | 2006-07-26 | 2008-12-25 | テバ ファーマシューティカル インダストリーズ リミティド | Method for synthesizing O-desmethylvenlafaxine |
JP2010229141A (en) * | 2010-05-19 | 2010-10-14 | Sumitomo Chemical Co Ltd | Method for producing camostat hydrochloride |
WO2016148135A1 (en) * | 2015-03-16 | 2016-09-22 | 武田薬品工業株式会社 | Therapeutic agent |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02183730A (en) * | 1989-01-09 | 1990-07-18 | Sanyo Electric Co Ltd | Cooker |
-
1979
- 1979-03-01 JP JP2257279A patent/JPS55115863A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008546850A (en) * | 2006-07-26 | 2008-12-25 | テバ ファーマシューティカル インダストリーズ リミティド | Method for synthesizing O-desmethylvenlafaxine |
JP2010229141A (en) * | 2010-05-19 | 2010-10-14 | Sumitomo Chemical Co Ltd | Method for producing camostat hydrochloride |
WO2016148135A1 (en) * | 2015-03-16 | 2016-09-22 | 武田薬品工業株式会社 | Therapeutic agent |
Also Published As
Publication number | Publication date |
---|---|
JPS6141510B2 (en) | 1986-09-16 |
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