JPS55115865A - Guanidinobenzoic acid derivative and its preparation - Google Patents

Guanidinobenzoic acid derivative and its preparation

Info

Publication number
JPS55115865A
JPS55115865A JP2257179A JP2257179A JPS55115865A JP S55115865 A JPS55115865 A JP S55115865A JP 2257179 A JP2257179 A JP 2257179A JP 2257179 A JP2257179 A JP 2257179A JP S55115865 A JPS55115865 A JP S55115865A
Authority
JP
Japan
Prior art keywords
compound
formula
preparation
pyridine
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2257179A
Other languages
Japanese (ja)
Other versions
JPS6237032B2 (en
Inventor
Setsuo Fujii
Takeshi Watanabe
Seiji Shioda
Itsuo Okumoto
Naohiro Kayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP2257179A priority Critical patent/JPS55115865A/en
Priority to GB8003854A priority patent/GB2044760B/en
Priority to DE19803005580 priority patent/DE3005580A1/en
Priority to US06/123,609 priority patent/US4283418A/en
Priority to FR8004573A priority patent/FR2450251A1/en
Publication of JPS55115865A publication Critical patent/JPS55115865A/en
Publication of JPS6237032B2 publication Critical patent/JPS6237032B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 and R2 are H or lower alkyl groups) or its acid addition salt.
EXAMPLE: p-(p-Guanidinobenzoyloxy)-N,N-dimethylbenzenesulfonamide.
USE: Remedies for acute pancreatitis or antiplasmin, effective against hemorrhagic diseases.
PROCESS: A compound of formula II (X is halogen) is reacted with a compound of formula III in an inert solvent, e.g. pyridine, in the presence of a dehydrohalogenating agent, e.g. triethylamine or pyridine, at -20°C to room temperature for 1W5hr to give the compound of formula I. The starting compound of formula II can be obtained by reacting p-quanidinobenzoic acid with thionyl chloride under heating.
COPYRIGHT: (C)1980,JPO&Japio
JP2257179A 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation Granted JPS55115865A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2257179A JPS55115865A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation
GB8003854A GB2044760B (en) 1979-03-01 1980-02-05 Guanidinobenzoic acid derivatives
DE19803005580 DE3005580A1 (en) 1979-03-01 1980-02-14 GUANIDINOBENZOESAE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES
US06/123,609 US4283418A (en) 1979-03-01 1980-02-22 Guanidinobenzoic acid derivatives and process for their preparation
FR8004573A FR2450251A1 (en) 1979-03-01 1980-02-29 GUANIDINOBENZOIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2257179A JPS55115865A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS55115865A true JPS55115865A (en) 1980-09-06
JPS6237032B2 JPS6237032B2 (en) 1987-08-10

Family

ID=12086555

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2257179A Granted JPS55115865A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS55115865A (en)

Also Published As

Publication number Publication date
JPS6237032B2 (en) 1987-08-10

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