JPS5476532A - Preparation of guanidino-fatty acid derivative - Google Patents
Preparation of guanidino-fatty acid derivativeInfo
- Publication number
- JPS5476532A JPS5476532A JP14268677A JP14268677A JPS5476532A JP S5476532 A JPS5476532 A JP S5476532A JP 14268677 A JP14268677 A JP 14268677A JP 14268677 A JP14268677 A JP 14268677A JP S5476532 A JPS5476532 A JP S5476532A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- addition salt
- formula
- acid addition
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound for medical use in simple procedures and handling, by reacting an acid addition salt of guanidinocaproic acid with ethyl p-hydroxybenzoate in the presence of a condensing agent in an anhydrous inert solvent.
CONSTITUTION: An acid addition salt, e.g. guanidinocaproic acid hydrochloride, of a compound of formula I: (n is 4W6) is reacted with a compound, e.g. ethyl p-hydroxybenzoate, etc., of formula II: (X is H, halogen, alkyl, nitro, alkoxy, or alkoxycarbonyl group) in the presence of a condensing agent, e.g. N, N'-dicylo- hexylcarbodiimide, etc., which can be easily handled, in an anhydrous is inexpensive and suitable, and inert solvent, e.g. pyridine to give an acid addition salt, e.g. p-ethoxy-carbonylphenyl ester of guanidio-caproic acid, etc., of an guanidio fatty acid derivative of formula III.
USE: Remedies for acute pancreatitis. Strong inhibitory actions on trypsin and kallikrein.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14268677A JPS5476532A (en) | 1977-11-30 | 1977-11-30 | Preparation of guanidino-fatty acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14268677A JPS5476532A (en) | 1977-11-30 | 1977-11-30 | Preparation of guanidino-fatty acid derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5476532A true JPS5476532A (en) | 1979-06-19 |
| JPS5734828B2 JPS5734828B2 (en) | 1982-07-26 |
Family
ID=15321157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14268677A Granted JPS5476532A (en) | 1977-11-30 | 1977-11-30 | Preparation of guanidino-fatty acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5476532A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58177960A (en) * | 1982-04-13 | 1983-10-18 | Toho Iyaku Kenkyusho:Kk | Preparation of 6-guanidinocaproic acid-p-ethoxy- carbonylphenyl ester or its salt |
| JPS6061557A (en) * | 1983-09-14 | 1985-04-09 | Nitto Boseki Co Ltd | Production of arginyl-p-nitroanilide |
| US6388122B1 (en) | 1996-04-10 | 2002-05-14 | Ono Pharmaceutical Co., Ltd. | Tryptase inhibitor and novel guanidino derivatives |
| CN114714707A (en) * | 2022-05-11 | 2022-07-08 | 刘泽杰 | Breathable high-elasticity mask fabric and preparation method thereof |
-
1977
- 1977-11-30 JP JP14268677A patent/JPS5476532A/en active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58177960A (en) * | 1982-04-13 | 1983-10-18 | Toho Iyaku Kenkyusho:Kk | Preparation of 6-guanidinocaproic acid-p-ethoxy- carbonylphenyl ester or its salt |
| JPS6061557A (en) * | 1983-09-14 | 1985-04-09 | Nitto Boseki Co Ltd | Production of arginyl-p-nitroanilide |
| JPS6332348B2 (en) * | 1983-09-14 | 1988-06-29 | Nitto Boseki Co Ltd | |
| US6388122B1 (en) | 1996-04-10 | 2002-05-14 | Ono Pharmaceutical Co., Ltd. | Tryptase inhibitor and novel guanidino derivatives |
| CN114714707A (en) * | 2022-05-11 | 2022-07-08 | 刘泽杰 | Breathable high-elasticity mask fabric and preparation method thereof |
| CN114714707B (en) * | 2022-05-11 | 2024-04-12 | 苏州西铁牛电子商务有限公司 | Breathable high-elastic mask fabric and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5734828B2 (en) | 1982-07-26 |
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