JPS5350131A - Production of novel amidoxime derivatives and pharmaceutical composition - Google Patents
Production of novel amidoxime derivatives and pharmaceutical compositionInfo
- Publication number
- JPS5350131A JPS5350131A JP10250477A JP10250477A JPS5350131A JP S5350131 A JPS5350131 A JP S5350131A JP 10250477 A JP10250477 A JP 10250477A JP 10250477 A JP10250477 A JP 10250477A JP S5350131 A JPS5350131 A JP S5350131A
- Authority
- JP
- Japan
- Prior art keywords
- production
- pharmaceutical composition
- amidoxime derivatives
- novel
- novel amidoxime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU76CI1682A HU177578B (en) | 1976-08-27 | 1976-08-27 | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5350131A true JPS5350131A (en) | 1978-05-08 |
| JPS6216942B2 JPS6216942B2 (de) | 1987-04-15 |
Family
ID=10994625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10250477A Granted JPS5350131A (en) | 1976-08-27 | 1977-08-26 | Production of novel amidoxime derivatives and pharmaceutical composition |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5350131A (de) |
| AT (1) | AT355554B (de) |
| AU (1) | AU521432B2 (de) |
| BE (1) | BE858134A (de) |
| CA (1) | CA1077506A (de) |
| CH (1) | CH630344A5 (de) |
| CS (1) | CS204008B2 (de) |
| DD (1) | DD132433A5 (de) |
| DE (1) | DE2738589A1 (de) |
| DK (1) | DK150196C (de) |
| ES (1) | ES462346A1 (de) |
| FI (1) | FI68396C (de) |
| FR (1) | FR2362845A1 (de) |
| GB (1) | GB1582029A (de) |
| GR (1) | GR63623B (de) |
| HU (1) | HU177578B (de) |
| IL (1) | IL52804A (de) |
| NL (1) | NL187478C (de) |
| NO (1) | NO144793C (de) |
| PL (1) | PL107628B1 (de) |
| SE (1) | SE435280B (de) |
| SU (1) | SU730296A3 (de) |
| YU (2) | YU202377A (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4849522A (en) * | 1983-11-03 | 1989-07-18 | Merrell Dow Pharmaceuticals | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
| US5212314A (en) * | 1983-11-03 | 1993-05-18 | Merrell Dow Pharmaceuticals Inc. | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
| ZA848428B (en) * | 1983-11-03 | 1985-06-26 | Merrell Pharma Inc | Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones |
| JPH01169445A (ja) * | 1987-12-25 | 1989-07-04 | Fuji Photo Film Co Ltd | 焦点距離切換えカメラ |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HUT54347A (en) * | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| HUT78139A (hu) * | 1995-12-22 | 2000-11-28 | BIOREX Kutató és Fejlesztő Rt. | Készítmény, különösen a bőr öregedési folyamatainak mérséklésére |
| AU766831B2 (en) | 1998-05-11 | 2003-10-23 | Takeda Pharmaceutical Company Limited | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity |
| WO2000007580A2 (en) * | 1998-08-03 | 2000-02-17 | N-Gene Kutató Kft. | Pharmaceutical compositions against autoimmune diseases |
| AU2003202104B8 (en) | 2002-01-11 | 2008-10-02 | Cytrx Corporation | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| US20230416224A1 (en) | 2020-11-19 | 2023-12-28 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
-
1976
- 1976-08-27 HU HU76CI1682A patent/HU177578B/hu unknown
-
1977
- 1977-08-22 AT AT605477A patent/AT355554B/de not_active IP Right Cessation
- 1977-08-23 SE SE7709482A patent/SE435280B/xx not_active IP Right Cessation
- 1977-08-23 IL IL7752804A patent/IL52804A/xx unknown
- 1977-08-23 NL NLAANVRAGE7709276,A patent/NL187478C/xx not_active IP Right Cessation
- 1977-08-24 CS CS775551A patent/CS204008B2/cs unknown
- 1977-08-24 DD DD7700200719A patent/DD132433A5/de unknown
- 1977-08-24 GR GR54222A patent/GR63623B/el unknown
- 1977-08-25 GB GB35745/77A patent/GB1582029A/en not_active Expired
- 1977-08-25 YU YU02023/77A patent/YU202377A/xx unknown
- 1977-08-26 DK DK379777A patent/DK150196C/da not_active IP Right Cessation
- 1977-08-26 JP JP10250477A patent/JPS5350131A/ja active Granted
- 1977-08-26 DE DE19772738589 patent/DE2738589A1/de active Granted
- 1977-08-26 NO NO772958A patent/NO144793C/no unknown
- 1977-08-26 CH CH1047377A patent/CH630344A5/de not_active IP Right Cessation
- 1977-08-26 AU AU28254/77A patent/AU521432B2/en not_active Expired
- 1977-08-26 PL PL1977206476A patent/PL107628B1/pl unknown
- 1977-08-26 FI FI772551A patent/FI68396C/fi not_active IP Right Cessation
- 1977-08-26 SU SU772514754A patent/SU730296A3/ru active
- 1977-08-26 FR FR7726070A patent/FR2362845A1/fr active Granted
- 1977-08-26 CA CA285,529A patent/CA1077506A/en not_active Expired
- 1977-08-26 BE BE180447A patent/BE858134A/xx not_active IP Right Cessation
- 1977-09-08 ES ES77462346A patent/ES462346A1/es not_active Expired
-
1982
- 1982-10-22 YU YU02377/82A patent/YU237782A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI68396B (fi) | 1985-05-31 |
| AU521432B2 (en) | 1982-04-01 |
| ATA605477A (de) | 1979-08-15 |
| NO772958L (no) | 1978-02-28 |
| NO144793B (no) | 1981-08-03 |
| CH630344A5 (en) | 1982-06-15 |
| SU730296A3 (ru) | 1980-04-25 |
| IL52804A (en) | 1981-06-29 |
| DK150196C (da) | 1987-07-06 |
| HU177578B (en) | 1981-11-28 |
| CS204008B2 (en) | 1981-03-31 |
| FI772551A (fi) | 1978-02-28 |
| NO144793C (no) | 1981-11-11 |
| JPS6216942B2 (de) | 1987-04-15 |
| IL52804A0 (en) | 1977-10-31 |
| FR2362845A1 (fr) | 1978-03-24 |
| PL107628B1 (pl) | 1980-02-29 |
| NL7709276A (nl) | 1978-03-01 |
| DK379777A (da) | 1978-02-28 |
| AU2825477A (en) | 1979-03-01 |
| DE2738589A1 (de) | 1978-03-02 |
| ES462346A1 (es) | 1978-06-16 |
| YU202377A (en) | 1983-12-31 |
| YU237782A (en) | 1983-12-31 |
| DK150196B (da) | 1987-01-05 |
| SE435280B (sv) | 1984-09-17 |
| GR63623B (en) | 1979-11-27 |
| NL187478C (nl) | 1991-10-16 |
| DD132433A5 (de) | 1978-09-27 |
| GB1582029A (en) | 1980-12-31 |
| FI68396C (fi) | 1985-09-10 |
| BE858134A (fr) | 1977-12-16 |
| FR2362845B1 (de) | 1981-01-09 |
| AT355554B (de) | 1980-03-10 |
| SE7709482L (sv) | 1978-02-28 |
| CA1077506A (en) | 1980-05-13 |
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