JPS5223001A - Process for elimination of formyl group - Google Patents

Process for elimination of formyl group

Info

Publication number
JPS5223001A
JPS5223001A JP50098817A JP9881775A JPS5223001A JP S5223001 A JPS5223001 A JP S5223001A JP 50098817 A JP50098817 A JP 50098817A JP 9881775 A JP9881775 A JP 9881775A JP S5223001 A JPS5223001 A JP S5223001A
Authority
JP
Japan
Prior art keywords
formyl group
elimination
compounds
formyl
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP50098817A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5726588B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Tadashi Takemoto
Fusayoshi Kakizaki
Yasuo Ariyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP50098817A priority Critical patent/JPS5223001A/ja
Priority to GB32945/76A priority patent/GB1497248A/en
Priority to AU16636/76A priority patent/AU499510B2/en
Priority to US05/713,270 priority patent/US4071511A/en
Priority to DE2635948A priority patent/DE2635948C2/de
Priority to NL7608965A priority patent/NL7608965A/xx
Priority to FR7624681A priority patent/FR2320934A1/fr
Priority to CA259,023A priority patent/CA1075680A/en
Priority to CH1035976A priority patent/CH613687A5/xx
Publication of JPS5223001A publication Critical patent/JPS5223001A/ja
Publication of JPS5726588B2 publication Critical patent/JPS5726588B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/122—Hydrolysis with acids different from HF

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP50098817A 1975-08-14 1975-08-14 Process for elimination of formyl group Granted JPS5223001A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP50098817A JPS5223001A (en) 1975-08-14 1975-08-14 Process for elimination of formyl group
GB32945/76A GB1497248A (en) 1975-08-14 1976-08-06 Process for removing n-formyl masking groups from esters
AU16636/76A AU499510B2 (en) 1975-08-14 1976-08-06 Method of removing formyl groups fromn-formyl-amino or peptide esters
US05/713,270 US4071511A (en) 1975-08-14 1976-08-10 Method of removing formyl groups from N-formyl-amino acid and N-formyl-peptide esters having free carboxyl groups
DE2635948A DE2635948C2 (de) 1975-08-14 1976-08-10 Verfahren zur Abspaltung von Formylgruppen aus N-Formylaminosäureestern und N-Formylpeptidestern mit freien Carboxylgruppen
NL7608965A NL7608965A (nl) 1975-08-14 1976-08-12 Werkwijze voor het verwijderen van formylgroe- pen uit n-formylaminozuur en n-formylpeptide esters met vrije carboxygroepen.
FR7624681A FR2320934A1 (fr) 1975-08-14 1976-08-12 Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libres
CA259,023A CA1075680A (en) 1975-08-14 1976-08-13 Method of removing formyl groups from n-formyl-amino acid and n-formyl-peptide esters having free carboxyl groups
CH1035976A CH613687A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-08-14 1976-08-13

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50098817A JPS5223001A (en) 1975-08-14 1975-08-14 Process for elimination of formyl group

Publications (2)

Publication Number Publication Date
JPS5223001A true JPS5223001A (en) 1977-02-21
JPS5726588B2 JPS5726588B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-06-05

Family

ID=14229861

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50098817A Granted JPS5223001A (en) 1975-08-14 1975-08-14 Process for elimination of formyl group

Country Status (9)

Country Link
US (1) US4071511A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5223001A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU499510B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1075680A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH613687A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2635948C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2320934A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1497248A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7608965A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
JPH03169894A (ja) * 1982-04-22 1991-07-23 Ajinomoto Co Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルまたはその塩酸塩の製法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
JPS57125891U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1981-01-31 1982-08-05
JPS57131746A (en) * 1981-02-10 1982-08-14 Ajinomoto Co Inc Removal of n-formyl group
IE810577L (en) * 1983-05-31 1982-09-16 Prendergast Angela Apparatus for fermentation
IT1194795B (it) * 1981-05-13 1988-09-28 Pierrel Spa Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati
JPS5821687U (ja) * 1981-08-03 1983-02-10 新日軽株式会社 建具
GB8321802D0 (en) * 1983-08-12 1983-09-14 Erba Farmitalia Aspartame synthesis
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
ES8703487A1 (es) * 1984-12-27 1987-03-01 Mitsui Toatsu Chemicals Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
IT1190395B (it) * 1985-09-30 1988-02-16 Lark Spa Procedimento per la rimozione del gruppo formile da un estere di n-formil peptide o di n-formil amminoacido
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
DE3780585T2 (de) * 1986-12-05 1993-03-18 Mitsui Toatsu Chemicals Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide.
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
IT1270852B (it) * 1992-08-27 1997-05-13 Miwon Co Ltd Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina.
AU2002314773B2 (en) * 2001-05-09 2008-05-01 Celmed Oncology (Usa), Inc. Peptide deformylase activated prodrugs
CN1662238A (zh) * 2002-04-18 2005-08-31 塞米得肿瘤学美国公司 肽去甲酰酶活化的前体药物
BR0315537A (pt) * 2002-11-14 2005-09-27 Celmed Oncology Usa Inc Pró-drogas ativadas por peptìdeo desformilase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2053188C3 (de) * 1970-10-29 1979-11-22 Ajinomoto Co. Inc., Tokio Verfahren zur Herstellung von Niederalkylestern des a -L-Asparagyl- L-phenylalanins
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
JPH03169894A (ja) * 1982-04-22 1991-07-23 Ajinomoto Co Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルまたはその塩酸塩の製法

Also Published As

Publication number Publication date
NL7608965A (nl) 1977-02-16
CA1075680A (en) 1980-04-15
AU499510B2 (en) 1979-04-26
CH613687A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-10-15
GB1497248A (en) 1978-01-05
DE2635948C2 (de) 1985-11-14
AU1663676A (en) 1978-02-09
FR2320934B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-05-23
JPS5726588B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-06-05
US4071511A (en) 1978-01-31
FR2320934A1 (fr) 1977-03-11
DE2635948A1 (de) 1977-03-03

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