IT1270852B - Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina. - Google Patents

Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina.

Info

Publication number
IT1270852B
IT1270852B ITTO930336A ITTO930336A IT1270852B IT 1270852 B IT1270852 B IT 1270852B IT TO930336 A ITTO930336 A IT TO930336A IT TO930336 A ITTO930336 A IT TO930336A IT 1270852 B IT1270852 B IT 1270852B
Authority
IT
Italy
Prior art keywords
aspartyl
methyl ester
phenylalanine
fenylalanine
alpha
Prior art date
Application number
ITTO930336A
Other languages
English (en)
Inventor
Kyung Sok Choi
Dae Kwon Joo
Min Soo Han
E Nam Hwang
Original Assignee
Miwon Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miwon Co Ltd filed Critical Miwon Co Ltd
Publication of ITTO930336A0 publication Critical patent/ITTO930336A0/it
Publication of ITTO930336A1 publication Critical patent/ITTO930336A1/it
Application granted granted Critical
Publication of IT1270852B publication Critical patent/IT1270852B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimento per la preparazione con resa elevata dell'estere metilico di d-L-fenilalanina, comprendente le fasi che consistono nell'esterificare d-L-aspartil-L-fenilalanina con metanolo rimuovendo al contempo l'acqua formatasi durante l'esterificazione mediante evaporazione continua, accoppiare l'estere metilico della d-L- aspartil-L-fenilalanina ottenuto con anidride N-formil-l-aspartica, deformilare l'ottenuto estere metilico di N-formil-l-aspartil- L-fenilalanina, cristallizzare l'estere metilico di d- L-aspartil-L-fenilalanina formato sotto forma di cloridrato dell'estere metilico di d- L-aspartil-L-fenilalanina, raccogliere il primo cloridrato dell'estere metilico di d- L-aspartil-L-fenilalanina, esterificare la d- L-aspartil-L-fenilalanina nel filtrato per prodotte il secondo estere metilico di d- L-aspartil-L-fenilalanina e riunire il primo e secondo estere metilico di d- L-aspartil-L-fenilalanina.
ITTO930336A 1992-08-27 1993-05-14 Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina. IT1270852B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93596192A 1992-08-27 1992-08-27

Publications (3)

Publication Number Publication Date
ITTO930336A0 ITTO930336A0 (it) 1993-05-14
ITTO930336A1 ITTO930336A1 (it) 1994-11-14
IT1270852B true IT1270852B (it) 1997-05-13

Family

ID=25467976

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO930336A IT1270852B (it) 1992-08-27 1993-05-14 Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina.

Country Status (8)

Country Link
US (1) US5334746A (it)
KR (1) KR970009594B1 (it)
CH (1) CH687825A5 (it)
DE (1) DE4328967A1 (it)
FR (1) FR2695128B1 (it)
GB (1) GB2270311B (it)
IT (1) IT1270852B (it)
NL (1) NL9301303A (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010096940A (ko) * 2000-04-19 2001-11-08 고두모 알파-엘-아스파틸-엘-페닐알라닌 메틸에스테르 염산염의제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492131A (en) * 1966-04-18 1970-01-27 Searle & Co Peptide sweetening agents
US3786039A (en) * 1969-04-30 1974-01-15 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
US4680403A (en) * 1985-01-17 1987-07-14 Ajinomoto Co., Inc. Process for producing N-protected-α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
JPH0657719B2 (ja) * 1986-06-03 1994-08-03 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの回収方法
KR910007940B1 (ko) * 1989-04-14 1991-10-04 주식회사 미원 L-페닐알라닌 메틸에스테르 염산염의 정석법

Also Published As

Publication number Publication date
KR970009594B1 (en) 1997-06-14
GB2270311B (en) 1996-10-02
KR940003905A (ko) 1994-03-14
ITTO930336A1 (it) 1994-11-14
ITTO930336A0 (it) 1993-05-14
NL9301303A (nl) 1994-03-16
US5334746A (en) 1994-08-02
GB2270311A (en) 1994-03-09
GB9317124D0 (en) 1993-09-29
FR2695128B1 (fr) 1995-07-07
DE4328967A1 (de) 1994-03-03
CH687825A5 (de) 1997-02-28
FR2695128A1 (fr) 1994-03-04

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970813