FR2320934A1 - Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libres - Google Patents
Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libresInfo
- Publication number
- FR2320934A1 FR2320934A1 FR7624681A FR7624681A FR2320934A1 FR 2320934 A1 FR2320934 A1 FR 2320934A1 FR 7624681 A FR7624681 A FR 7624681A FR 7624681 A FR7624681 A FR 7624681A FR 2320934 A1 FR2320934 A1 FR 2320934A1
- Authority
- FR
- France
- Prior art keywords
- radicals
- formylaminoacid
- formylpeptides
- esters
- containing free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- C07K1/122—Hydrolysis with acids different from HF
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP50098817A JPS5223001A (en) | 1975-08-14 | 1975-08-14 | Process for elimination of formyl group |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2320934A1 true FR2320934A1 (fr) | 1977-03-11 |
FR2320934B1 FR2320934B1 (fr) | 1980-05-23 |
Family
ID=14229861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7624681A Granted FR2320934A1 (fr) | 1975-08-14 | 1976-08-12 | Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libres |
Country Status (9)
Country | Link |
---|---|
US (1) | US4071511A (fr) |
JP (1) | JPS5223001A (fr) |
AU (1) | AU499510B2 (fr) |
CA (1) | CA1075680A (fr) |
CH (1) | CH613687A5 (fr) |
DE (1) | DE2635948C2 (fr) |
FR (1) | FR2320934A1 (fr) |
GB (1) | GB1497248A (fr) |
NL (1) | NL7608965A (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX4704E (es) * | 1976-12-27 | 1982-08-04 | Monsanto Co | Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina |
JPS57125891U (fr) * | 1981-01-31 | 1982-08-05 | ||
JPS57131746A (en) * | 1981-02-10 | 1982-08-14 | Ajinomoto Co Inc | Removal of n-formyl group |
IE810577L (en) * | 1983-05-31 | 1982-09-16 | Prendergast Angela | Apparatus for fermentation |
IT1194795B (it) * | 1981-05-13 | 1988-09-28 | Pierrel Spa | Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati |
JPS5821687U (ja) * | 1981-08-03 | 1983-02-10 | 新日軽株式会社 | 建具 |
JPS58185545A (ja) * | 1982-04-22 | 1983-10-29 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
JPH03169894A (ja) * | 1982-04-22 | 1991-07-23 | Ajinomoto Co Inc | α―L―アスパルチル―L―フェニルアラニンメチルエステルまたはその塩酸塩の製法 |
GB8321802D0 (en) * | 1983-08-12 | 1983-09-14 | Erba Farmitalia | Aspartame synthesis |
JPH07636B2 (ja) * | 1984-12-17 | 1995-01-11 | 三井東圧化学株式会社 | N−ホルミル−α−アスパルチルフエニルアラニンの製造法 |
ES8703487A1 (es) * | 1984-12-27 | 1987-03-01 | Mitsui Toatsu Chemicals | Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester |
AU561384B2 (en) * | 1985-03-26 | 1987-05-07 | Mitsui Toatsu Chemicals Inc. | Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof |
IT1190395B (it) * | 1985-09-30 | 1988-02-16 | Lark Spa | Procedimento per la rimozione del gruppo formile da un estere di n-formil peptide o di n-formil amminoacido |
JPH0680075B2 (ja) * | 1985-12-24 | 1994-10-12 | 味の素株式会社 | N―ホルミル―α―L―アスパルチル―L―フェニルアラニンメチルエステルの製造法 |
ES2042583T3 (es) * | 1986-12-05 | 1993-12-16 | Mitsui Toatsu Chemicals | Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros. |
JPH0832719B2 (ja) * | 1986-12-19 | 1996-03-29 | 三井東圧化学株式会社 | 吸湿性の小さいα−L−アスパルチル−L−フエニルアラニンメチルエステルの製造法 |
IT1270852B (it) * | 1992-08-27 | 1997-05-13 | Miwon Co Ltd | Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina. |
US7163923B2 (en) * | 2001-05-09 | 2007-01-16 | Celmed Oncology (Usa), Inc. | Peptide deformylase activated prodrugs |
WO2003088913A2 (fr) * | 2002-04-18 | 2003-10-30 | Celmed Oncology (Usa), Inc. | Promedicaments actives par peptide deformylase |
BR0315537A (pt) * | 2002-11-14 | 2005-09-27 | Celmed Oncology Usa Inc | Pró-drogas ativadas por peptìdeo desformilase |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2053188C3 (de) * | 1970-10-29 | 1979-11-22 | Ajinomoto Co. Inc., Tokio | Verfahren zur Herstellung von Niederalkylestern des a -L-Asparagyl- L-phenylalanins |
US3933781A (en) * | 1973-11-05 | 1976-01-20 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters |
JPS5823380B2 (ja) * | 1974-12-05 | 1983-05-14 | 味の素株式会社 | ホルミルキノ ダツリホウ |
-
1975
- 1975-08-14 JP JP50098817A patent/JPS5223001A/ja active Granted
-
1976
- 1976-08-06 AU AU16636/76A patent/AU499510B2/en not_active Expired
- 1976-08-06 GB GB32945/76A patent/GB1497248A/en not_active Expired
- 1976-08-10 DE DE2635948A patent/DE2635948C2/de not_active Expired
- 1976-08-10 US US05/713,270 patent/US4071511A/en not_active Expired - Lifetime
- 1976-08-12 NL NL7608965A patent/NL7608965A/xx not_active Application Discontinuation
- 1976-08-12 FR FR7624681A patent/FR2320934A1/fr active Granted
- 1976-08-13 CH CH1035976A patent/CH613687A5/xx not_active IP Right Cessation
- 1976-08-13 CA CA259,023A patent/CA1075680A/fr not_active Expired
Non-Patent Citations (1)
Title |
---|
NV6013/58 * |
Also Published As
Publication number | Publication date |
---|---|
JPS5223001A (en) | 1977-02-21 |
GB1497248A (en) | 1978-01-05 |
DE2635948A1 (de) | 1977-03-03 |
CH613687A5 (fr) | 1979-10-15 |
JPS5726588B2 (fr) | 1982-06-05 |
NL7608965A (nl) | 1977-02-16 |
DE2635948C2 (de) | 1985-11-14 |
CA1075680A (fr) | 1980-04-15 |
FR2320934B1 (fr) | 1980-05-23 |
AU499510B2 (en) | 1979-04-26 |
AU1663676A (en) | 1978-02-09 |
US4071511A (en) | 1978-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
CD | Change of name or company name | ||
ST | Notification of lapse |