AU499510B2 - Method of removing formyl groups fromn-formyl-amino or peptide esters - Google Patents

Method of removing formyl groups fromn-formyl-amino or peptide esters

Info

Publication number
AU499510B2
AU499510B2 AU16636/76A AU1663676A AU499510B2 AU 499510 B2 AU499510 B2 AU 499510B2 AU 16636/76 A AU16636/76 A AU 16636/76A AU 1663676 A AU1663676 A AU 1663676A AU 499510 B2 AU499510 B2 AU 499510B2
Authority
AU
Australia
Prior art keywords
formyl
fromn
amino
peptide esters
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU16636/76A
Other languages
English (en)
Other versions
AU1663676A (en
Inventor
T. Kakizaki. F. Ariyoshi Y Takemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
AJINOMOTO CO Inc G D SEARLE and
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AJINOMOTO CO Inc G D SEARLE and filed Critical AJINOMOTO CO Inc G D SEARLE and
Publication of AU1663676A publication Critical patent/AU1663676A/en
Application granted granted Critical
Publication of AU499510B2 publication Critical patent/AU499510B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/122—Hydrolysis with acids different from HF

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU16636/76A 1975-08-14 1976-08-06 Method of removing formyl groups fromn-formyl-amino or peptide esters Expired AU499510B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JPJP98817/75 1975-08-14
JP50098817A JPS5223001A (en) 1975-08-14 1975-08-14 Process for elimination of formyl group

Publications (2)

Publication Number Publication Date
AU1663676A AU1663676A (en) 1978-02-09
AU499510B2 true AU499510B2 (en) 1979-04-26

Family

ID=14229861

Family Applications (1)

Application Number Title Priority Date Filing Date
AU16636/76A Expired AU499510B2 (en) 1975-08-14 1976-08-06 Method of removing formyl groups fromn-formyl-amino or peptide esters

Country Status (9)

Country Link
US (1) US4071511A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5223001A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU499510B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1075680A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH613687A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2635948C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2320934A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1497248A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7608965A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
JPS57125891U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1981-01-31 1982-08-05
JPS57131746A (en) * 1981-02-10 1982-08-14 Ajinomoto Co Inc Removal of n-formyl group
IE810577L (en) * 1983-05-31 1982-09-16 Prendergast Angela Apparatus for fermentation
IT1194795B (it) * 1981-05-13 1988-09-28 Pierrel Spa Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati
JPS5821687U (ja) * 1981-08-03 1983-02-10 新日軽株式会社 建具
JPH03169894A (ja) * 1982-04-22 1991-07-23 Ajinomoto Co Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルまたはその塩酸塩の製法
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
GB8321802D0 (en) * 1983-08-12 1983-09-14 Erba Farmitalia Aspartame synthesis
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
ES8703487A1 (es) * 1984-12-27 1987-03-01 Mitsui Toatsu Chemicals Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
IT1190395B (it) * 1985-09-30 1988-02-16 Lark Spa Procedimento per la rimozione del gruppo formile da un estere di n-formil peptide o di n-formil amminoacido
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
DE3780585T2 (de) * 1986-12-05 1993-03-18 Mitsui Toatsu Chemicals Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide.
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
IT1270852B (it) * 1992-08-27 1997-05-13 Miwon Co Ltd Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina.
AU2002314773B2 (en) * 2001-05-09 2008-05-01 Celmed Oncology (Usa), Inc. Peptide deformylase activated prodrugs
CN1662238A (zh) * 2002-04-18 2005-08-31 塞米得肿瘤学美国公司 肽去甲酰酶活化的前体药物
BR0315537A (pt) * 2002-11-14 2005-09-27 Celmed Oncology Usa Inc Pró-drogas ativadas por peptìdeo desformilase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2053188C3 (de) * 1970-10-29 1979-11-22 Ajinomoto Co. Inc., Tokio Verfahren zur Herstellung von Niederalkylestern des a -L-Asparagyl- L-phenylalanins
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ

Also Published As

Publication number Publication date
NL7608965A (nl) 1977-02-16
CA1075680A (en) 1980-04-15
CH613687A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-10-15
GB1497248A (en) 1978-01-05
DE2635948C2 (de) 1985-11-14
JPS5223001A (en) 1977-02-21
AU1663676A (en) 1978-02-09
FR2320934B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-05-23
JPS5726588B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-06-05
US4071511A (en) 1978-01-31
FR2320934A1 (fr) 1977-03-11
DE2635948A1 (de) 1977-03-03

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