FR2320934A1 - Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libres - Google Patents

Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libres

Info

Publication number
FR2320934A1
FR2320934A1 FR7624681A FR7624681A FR2320934A1 FR 2320934 A1 FR2320934 A1 FR 2320934A1 FR 7624681 A FR7624681 A FR 7624681A FR 7624681 A FR7624681 A FR 7624681A FR 2320934 A1 FR2320934 A1 FR 2320934A1
Authority
FR
France
Prior art keywords
radicals
formylaminoacid
formylpeptides
esters
containing free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7624681A
Other languages
English (en)
French (fr)
Other versions
FR2320934B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of FR2320934A1 publication Critical patent/FR2320934A1/fr
Application granted granted Critical
Publication of FR2320934B1 publication Critical patent/FR2320934B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/122—Hydrolysis with acids different from HF

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7624681A 1975-08-14 1976-08-12 Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libres Granted FR2320934A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50098817A JPS5223001A (en) 1975-08-14 1975-08-14 Process for elimination of formyl group

Publications (2)

Publication Number Publication Date
FR2320934A1 true FR2320934A1 (fr) 1977-03-11
FR2320934B1 FR2320934B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-05-23

Family

ID=14229861

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7624681A Granted FR2320934A1 (fr) 1975-08-14 1976-08-12 Procede pour eliminer les radicaux formyles d'esters de n-formylaminoacides ou de n-formylpeptides comportant des radicaux carboxy libres

Country Status (9)

Country Link
US (1) US4071511A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5223001A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU499510B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1075680A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH613687A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2635948C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2320934A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1497248A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7608965A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
JPS57125891U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1981-01-31 1982-08-05
JPS57131746A (en) * 1981-02-10 1982-08-14 Ajinomoto Co Inc Removal of n-formyl group
IE810577L (en) * 1983-05-31 1982-09-16 Prendergast Angela Apparatus for fermentation
IT1194795B (it) * 1981-05-13 1988-09-28 Pierrel Spa Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati
JPS5821687U (ja) * 1981-08-03 1983-02-10 新日軽株式会社 建具
JPH03169894A (ja) * 1982-04-22 1991-07-23 Ajinomoto Co Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルまたはその塩酸塩の製法
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
GB8321802D0 (en) * 1983-08-12 1983-09-14 Erba Farmitalia Aspartame synthesis
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
CA1277098C (en) * 1984-12-27 1990-11-27 Mitsui Toatsu Chemicals, Inc. Preparation process of -l-aspartyl-l-phenylalanine methyl ester
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
IT1190395B (it) * 1985-09-30 1988-02-16 Lark Spa Procedimento per la rimozione del gruppo formile da un estere di n-formil peptide o di n-formil amminoacido
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
ES2042583T3 (es) * 1986-12-05 1993-12-16 Mitsui Toatsu Chemicals Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros.
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
IT1270852B (it) * 1992-08-27 1997-05-13 Miwon Co Ltd Procedimento per la produzione dell'estere metilico di alfa-l-aspartil-l-fenilalanina.
JP4109123B2 (ja) * 2001-05-09 2008-07-02 セルメド オンコロジー （ユーエスエイ）， インコーポレイテッド ペプチドデホルミラーゼ活性化プロドラッグ
CN1662238A (zh) * 2002-04-18 2005-08-31 塞米得肿瘤学美国公司 肽去甲酰酶活化的前体药物
CA2505914A1 (en) * 2002-11-14 2004-05-27 Celmed Oncology (Usa), Inc. Peptide deformylase activated prodrugs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2053188C3 (de) * 1970-10-29 1979-11-22 Ajinomoto Co. Inc., Tokio Verfahren zur Herstellung von Niederalkylestern des a -L-Asparagyl- L-phenylalanins
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV6013/58 *

Also Published As

Publication number Publication date
JPS5726588B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-06-05
NL7608965A (nl) 1977-02-16
CH613687A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-10-15
AU1663676A (en) 1978-02-09
AU499510B2 (en) 1979-04-26
DE2635948A1 (de) 1977-03-03
GB1497248A (en) 1978-01-05
JPS5223001A (en) 1977-02-21
CA1075680A (en) 1980-04-15
US4071511A (en) 1978-01-31
DE2635948C2 (de) 1985-11-14
FR2320934B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-05-23

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Legal Events

Date Code Title Description
TP Transmission of property
CD Change of name or company name
ST Notification of lapse