JPS5217475A - New 11*benzoazolii*alkyl* piperidine derivatives - Google Patents

New 11*benzoazolii*alkyl* piperidine derivatives

Info

Publication number
JPS5217475A
JPS5217475A JP51085216A JP8521676A JPS5217475A JP S5217475 A JPS5217475 A JP S5217475A JP 51085216 A JP51085216 A JP 51085216A JP 8521676 A JP8521676 A JP 8521676A JP S5217475 A JPS5217475 A JP S5217475A
Authority
JP
Japan
Prior art keywords
benzoazolii
alkyl
new
piperidine derivatives
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP51085216A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6131109B2 (es
Inventor
Bandenberuku Jiyan
Ii Jiei Kenisu Rudo
Jiei Emu Shii Fuan De Maruseru
Ei Emu Tei Eichi Fua Aruberuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/687,139 external-priority patent/US4066772A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of JPS5217475A publication Critical patent/JPS5217475A/ja
Publication of JPS6131109B2 publication Critical patent/JPS6131109B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP51085216A 1975-07-21 1976-07-19 New 11*benzoazolii*alkyl* piperidine derivatives Granted JPS5217475A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59779375A 1975-07-21 1975-07-21
US05/687,139 US4066772A (en) 1975-07-21 1976-05-17 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
KR7601697A KR810000334B1 (ko) 1975-07-21 1976-07-12 1-(벤즈 아조릴알킬) 피페리딘 유도체의 제조방법

Publications (2)

Publication Number Publication Date
JPS5217475A true JPS5217475A (en) 1977-02-09
JPS6131109B2 JPS6131109B2 (es) 1986-07-17

Family

ID=27348142

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51085216A Granted JPS5217475A (en) 1975-07-21 1976-07-19 New 11*benzoazolii*alkyl* piperidine derivatives

Country Status (25)

Country Link
JP (1) JPS5217475A (es)
AT (1) AT364358B (es)
AU (1) AU511027B2 (es)
BG (1) BG26526A3 (es)
CA (1) CA1085852A (es)
CH (1) CH623820A5 (es)
CS (1) CS202550B2 (es)
DE (1) DE2632870A1 (es)
DK (1) DK154950C (es)
ES (3) ES449740A1 (es)
FI (1) FI62667C (es)
GB (1) GB1542514A (es)
HK (1) HK14180A (es)
IE (1) IE43496B1 (es)
IT (1) IT1062614B (es)
KE (1) KE3215A (es)
LU (1) LU75354A1 (es)
MY (1) MY8100017A (es)
NL (1) NL187442C (es)
NZ (1) NZ181256A (es)
PH (1) PH13710A (es)
PT (1) PT65387B (es)
RO (1) RO70566A (es)
SE (2) SE426490B (es)
YU (1) YU39969B (es)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248684A (ja) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd 新規なヨ−ドブチロフエノン誘導体およびその製造法
JPS62251313A (ja) * 1986-04-25 1987-11-02 信越ポリマー株式会社 結束装置
JP2007051154A (ja) * 1994-07-29 2007-03-01 Lab Del Dr Esteve Sa シグマ及び／又は５ｈｔ１ａレセプターに対する活性を有するテトラヒドロピリジン−（又は４−ヒドロキシピペリジン）アルキルアゾール
JP2010529011A (ja) * 2007-06-01 2010-08-26 コミッサリア ア レネルジ アトミック 抗寄生虫活性を有する化合物、アピコンプレクサにより引き起こされる感染症の治療へのそれらの適用
JP2010537969A (ja) * 2007-08-31 2010-12-09 パーデュー、ファーマ、リミテッド、パートナーシップ 置換キノキサリンタイプピペリジン化合物とその使用
JP2020534246A (ja) * 2016-02-04 2020-11-26 シンリックス ファーマ、エルエルシー 重水素化ドンペリドン組成物、方法、及び調製
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
JO2785B1 (en) * 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
JP4936897B2 (ja) 2003-12-18 2012-05-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗増殖剤としてのピリド−およびピリミドピリミジン誘導体
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
CA2654583C (en) 2006-07-13 2015-11-24 Janssen Pharmaceutica N.V. Mtki quinazoline derivatives
CA2693715C (en) 2007-07-27 2015-10-27 Janssen Pharmaceutica Nv Pyrrolopyrimidines
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (es) * 1962-06-13
BE633914A (es) * 1962-06-22
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
AU4698672A (en) * 1972-09-22 1972-11-09 Ciba-Geigy Ag Azacycloaliphatic compounds, process for their manufacture and compositions containing them
FR2218100A1 (en) * 1973-02-20 1974-09-13 Janssen Pharmaceutica Nv Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248684A (ja) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd 新規なヨ−ドブチロフエノン誘導体およびその製造法
JPS62251313A (ja) * 1986-04-25 1987-11-02 信越ポリマー株式会社 結束装置
JP2007051154A (ja) * 1994-07-29 2007-03-01 Lab Del Dr Esteve Sa シグマ及び／又は５ｈｔ１ａレセプターに対する活性を有するテトラヒドロピリジン−（又は４−ヒドロキシピペリジン）アルキルアゾール
JP2010529011A (ja) * 2007-06-01 2010-08-26 コミッサリア ア レネルジ アトミック 抗寄生虫活性を有する化合物、アピコンプレクサにより引き起こされる感染症の治療へのそれらの適用
JP2010537969A (ja) * 2007-08-31 2010-12-09 パーデュー、ファーマ、リミテッド、パートナーシップ 置換キノキサリンタイプピペリジン化合物とその使用
JP2020534246A (ja) * 2016-02-04 2020-11-26 シンリックス ファーマ、エルエルシー 重水素化ドンペリドン組成物、方法、及び調製
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation

Also Published As

Publication number Publication date
FI62667C (fi) 1983-02-10
CS202550B2 (en) 1981-01-30
PT65387B (en) 1978-06-09
SE8008713L (sv) 1980-12-11
DK327576A (da) 1977-01-22
BG26526A3 (bg) 1979-04-12
NL187442B (nl) 1991-05-01
IE43496L (en) 1977-01-21
FI762086A (es) 1977-01-22
IE43496B1 (en) 1981-03-11
DE2632870A1 (de) 1977-02-10
DK154950C (da) 1989-05-29
SE426490B (sv) 1983-01-24
RO70566A (ro) 1982-10-11
AU1596476A (en) 1978-01-19
SE435621B (sv) 1984-10-08
PT65387A (en) 1976-08-01
NZ181256A (en) 1978-04-28
JPS6131109B2 (es) 1986-07-17
ES461631A1 (es) 1978-12-01
PH13710A (en) 1980-09-09
ATA534776A (de) 1981-03-15
MY8100017A (en) 1981-12-31
NL7608023A (nl) 1977-01-25
CH623820A5 (en) 1981-06-30
ES461630A1 (es) 1978-06-16
YU179476A (en) 1983-01-21
GB1542514A (en) 1979-03-21
AU511027B2 (en) 1980-07-24
IT1062614B (it) 1984-10-20
AT364358B (de) 1981-10-12
ES449740A1 (es) 1978-02-16
NL187442C (nl) 1991-10-01
YU39969B (en) 1985-06-30
HK14180A (en) 1980-03-28
DK154950B (da) 1989-01-09
DE2632870C2 (es) 1989-02-16
SE7608265L (sv) 1977-01-22
FI62667B (fi) 1982-10-29
CA1085852A (en) 1980-09-16
LU75354A1 (es) 1977-02-28
KE3215A (en) 1982-07-09

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