JPH1171322A - アリール酢酸のアルカリ金属塩水溶液の連続的製造方法 - Google Patents
アリール酢酸のアルカリ金属塩水溶液の連続的製造方法Info
- Publication number
- JPH1171322A JPH1171322A JP10168322A JP16832298A JPH1171322A JP H1171322 A JPH1171322 A JP H1171322A JP 10168322 A JP10168322 A JP 10168322A JP 16832298 A JP16832298 A JP 16832298A JP H1171322 A JPH1171322 A JP H1171322A
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- alkali metal
- mixing
- metal salt
- introducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007864 aqueous solution Substances 0.000 title claims abstract description 61
- 229910052783 alkali metal Inorganic materials 0.000 title claims abstract description 34
- -1 alkali metal salt Chemical class 0.000 title claims description 62
- 239000002253 acid Substances 0.000 title claims description 16
- 238000010924 continuous production Methods 0.000 title description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 34
- 238000002156 mixing Methods 0.000 claims abstract description 32
- 239000000243 solution Substances 0.000 claims abstract description 25
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 238000006243 chemical reaction Methods 0.000 claims abstract description 15
- 230000003472 neutralizing effect Effects 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 8
- 238000000926 separation method Methods 0.000 claims abstract description 7
- 150000001340 alkali metals Chemical class 0.000 claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- 125000001931 aliphatic group Chemical group 0.000 claims abstract description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 25
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 18
- 230000003068 static effect Effects 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- ITIONVBQFUNVJV-UHFFFAOYSA-N Etomidoline Chemical compound C12=CC=CC=C2C(=O)N(CC)C1NC(C=C1)=CC=C1OCCN1CCCCC1 ITIONVBQFUNVJV-UHFFFAOYSA-N 0.000 claims description 12
- 229940006198 sodium phenylacetate Drugs 0.000 claims description 12
- 239000000376 reactant Substances 0.000 claims description 9
- JFOZPCWVLIBFCH-UHFFFAOYSA-M potassium;2-phenylacetate Chemical compound [K+].[O-]C(=O)CC1=CC=CC=C1 JFOZPCWVLIBFCH-UHFFFAOYSA-M 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 238000005904 alkaline hydrolysis reaction Methods 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 150000001447 alkali salts Chemical class 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 10
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
- 239000003513 alkali Substances 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 230000007062 hydrolysis Effects 0.000 abstract description 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract description 3
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 239000012429 reaction media Substances 0.000 abstract description 2
- 239000007858 starting material Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 description 32
- 235000011054 acetic acid Nutrition 0.000 description 23
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 13
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 6
- 239000010935 stainless steel Substances 0.000 description 6
- 239000007789 gas Substances 0.000 description 5
- 239000011261 inert gas Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- XVNXRPVJRCYHEW-UHFFFAOYSA-N 2-(4-ethoxy-3-methoxyphenyl)acetic acid Chemical compound CCOC1=CC=C(CC(O)=O)C=C1OC XVNXRPVJRCYHEW-UHFFFAOYSA-N 0.000 description 2
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 229910052776 Thorium Inorganic materials 0.000 description 2
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 229940049953 phenylacetate Drugs 0.000 description 2
- 229960003424 phenylacetic acid Drugs 0.000 description 2
- 239000003279 phenylacetic acid Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000011403 purification operation Methods 0.000 description 2
- GRTNZZWHXYRVDL-UHFFFAOYSA-N 2-(4-ethoxy-3-methoxyphenyl)acetonitrile Chemical compound CCOC1=CC=C(CC#N)C=C1OC GRTNZZWHXYRVDL-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/2425—Tubular reactors in parallel
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00094—Jackets
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9707440A FR2764600B1 (fr) | 1997-06-16 | 1997-06-16 | Procede continu de fabrication de solutions aqueuses de sels alcalins d'acides arylacetiques |
| FR9707440 | 1997-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH1171322A true JPH1171322A (ja) | 1999-03-16 |
Family
ID=9508022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10168322A Pending JPH1171322A (ja) | 1997-06-16 | 1998-06-16 | アリール酢酸のアルカリ金属塩水溶液の連続的製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0885872B1 (enExample) |
| JP (1) | JPH1171322A (enExample) |
| CN (1) | CN1203220A (enExample) |
| AT (1) | ATE209176T1 (enExample) |
| CA (1) | CA2238398A1 (enExample) |
| DE (1) | DE69803244T2 (enExample) |
| ES (1) | ES2167851T3 (enExample) |
| FR (1) | FR2764600B1 (enExample) |
| IN (1) | IN187756B (enExample) |
| PT (1) | PT885872E (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1300090C (zh) * | 2005-03-02 | 2007-02-14 | 杭州师范学院 | 一种芳基乙酸的制备方法 |
| CN106278859B (zh) * | 2016-08-24 | 2019-03-12 | 河北诚信集团有限公司 | 一种高品质苯乙酸的生产工艺 |
| CN113600119A (zh) * | 2021-08-04 | 2021-11-05 | 江苏聚双环新材料科技有限公司 | 自留分离式供料罐 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2817681A (en) * | 1954-12-20 | 1957-12-24 | Monsanto Chemicals | Arylacetic acids |
| DE1909440A1 (de) * | 1968-03-18 | 1969-11-13 | Lummos Company | Verfahren zur Herstellung von aromatischen Carbonsaeuren |
| US4031243A (en) * | 1975-07-03 | 1977-06-21 | Juste, S.A. Quimico-Farmaceutica | 2-(4-Isobutyl phenyl)butyric acid, salts thereof, and pharmaceutical compositions containing the same |
-
1997
- 1997-06-16 FR FR9707440A patent/FR2764600B1/fr not_active Expired - Fee Related
-
1998
- 1998-05-21 CA CA002238398A patent/CA2238398A1/fr not_active Abandoned
- 1998-05-26 EP EP98401244A patent/EP0885872B1/fr not_active Expired - Lifetime
- 1998-05-26 DE DE69803244T patent/DE69803244T2/de not_active Expired - Lifetime
- 1998-05-26 ES ES98401244T patent/ES2167851T3/es not_active Expired - Lifetime
- 1998-05-26 PT PT98401244T patent/PT885872E/pt unknown
- 1998-05-26 AT AT98401244T patent/ATE209176T1/de not_active IP Right Cessation
- 1998-06-16 CN CN98109896.7A patent/CN1203220A/zh active Pending
- 1998-06-16 JP JP10168322A patent/JPH1171322A/ja active Pending
- 1998-06-16 IN IN1305MA1998 patent/IN187756B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69803244T2 (de) | 2002-08-08 |
| CN1203220A (zh) | 1998-12-30 |
| FR2764600A1 (fr) | 1998-12-18 |
| ATE209176T1 (de) | 2001-12-15 |
| EP0885872B1 (fr) | 2001-11-21 |
| DE69803244D1 (de) | 2002-02-21 |
| IN187756B (enExample) | 2002-06-15 |
| FR2764600B1 (fr) | 1999-08-20 |
| EP0885872A1 (fr) | 1998-12-23 |
| ES2167851T3 (es) | 2002-05-16 |
| CA2238398A1 (fr) | 1998-12-16 |
| PT885872E (pt) | 2002-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109180466B (zh) | 一种卤代乙酰氯的光氧化制备方法 | |
| CN103857390A (zh) | 用于制备hmb及其盐的方法 | |
| JP2786424B2 (ja) | シアン化水素とアルデヒドとの縮合方法 | |
| EP1124799A1 (fr) | Procede de preparation de la methionine | |
| SU489312A3 (ru) | Способ получени тетрахлорфталонитрила | |
| JPH1171322A (ja) | アリール酢酸のアルカリ金属塩水溶液の連続的製造方法 | |
| JP2761761B2 (ja) | グリオキシル酸の水性溶液の工業的製造方法 | |
| US5041647A (en) | Process for producing trifluoroacetic acid and trifluoroacetyl chloride | |
| JP2734876B2 (ja) | 光学活性４−クロロ−３−ヒドロキシブチロニトリルの製造方法 | |
| JPS61238745A (ja) | アリルアルコ−ルの製造法 | |
| JPH08795B2 (ja) | 炭酸ジアリ−ルの製造方法 | |
| US6162946A (en) | Processing for producing allyl 2-hydroxyisobutyrate | |
| JPH0418049A (ja) | 不飽和脂肪酸低級アルキルエステルのオゾン化物の酸素酸化分解方法 | |
| US5536877A (en) | Preparation of arylbenzylamines | |
| JP2623810B2 (ja) | α―ヒドロキシイソ酪酸アミドの製造方法 | |
| KR20010042773A (ko) | 디메틸아세트아미드의 제조방법 | |
| JP4131025B2 (ja) | ケタジン及び水加ヒドラジンの製造方法 | |
| JPH1072392A (ja) | オリゴグリセリンの製造方法 | |
| WO1999008998A1 (en) | Process for producing formamide | |
| US6423853B1 (en) | Continuous ozonolysis of cycloalkenes into ozonides | |
| JP3781549B2 (ja) | モノエチレングリコールの製造方法 | |
| WO2023095077A1 (en) | A process for the treatment of tail gases | |
| CN119306610A (zh) | 一种2-氯-4-氟-5-硝基苯甲酸的合成方法 | |
| JPS59157045A (ja) | ヘキサフルオロアセトン水和物の脱水方法 | |
| SU793991A1 (ru) | Способ получени фторангидридовКАРбОНОВыХ КиСлОТ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 19991012 |