JPH11513984A - 成長ホルモン分泌促進剤の製造方法 - Google Patents

成長ホルモン分泌促進剤の製造方法

Info

Publication number
JPH11513984A
JPH11513984A JP9516736A JP51673697A JPH11513984A JP H11513984 A JPH11513984 A JP H11513984A JP 9516736 A JP9516736 A JP 9516736A JP 51673697 A JP51673697 A JP 51673697A JP H11513984 A JPH11513984 A JP H11513984A
Authority
JP
Japan
Prior art keywords
formula
compound
acid
amino
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9516736A
Other languages
English (en)
Japanese (ja)
Inventor
ホートン，ピーター・ジー
ホウピス，イオアニス
モリーナ，オードリー
リンチ，ジヨウジフ・イー
ボラント，ラルフ・ピー
Original Assignee
メルク エンド カンパニー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602949.1A external-priority patent/GB9602949D0/en
Application filed by メルク エンド カンパニー インコーポレーテッド filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JPH11513984A publication Critical patent/JPH11513984A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP9516736A 1995-10-27 1996-10-23 成長ホルモン分泌促進剤の製造方法 Pending JPH11513984A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US589895P 1995-10-27 1995-10-27
GB60/005,898 1996-02-13
GBGB9602949.1A GB9602949D0 (en) 1996-02-13 1996-02-13 Process for the preparation of a growth hormone secretagogue
GB9602949.1 1996-02-13
PCT/US1996/016954 WO1997015573A1 (en) 1995-10-27 1996-10-23 Process for the preparation of a growth hormone secretagogue

Publications (1)

Publication Number Publication Date
JPH11513984A true JPH11513984A (ja) 1999-11-30

Family

ID=26308687

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9516736A Pending JPH11513984A (ja) 1995-10-27 1996-10-23 成長ホルモン分泌促進剤の製造方法

Country Status (14)

Country Link
EP (1) EP0863900A1 (hu)
JP (1) JPH11513984A (hu)
KR (1) KR19990067097A (hu)
AR (1) AR004124A1 (hu)
AU (1) AU7468596A (hu)
BR (1) BR9610887A (hu)
CA (1) CA2235511A1 (hu)
CZ (1) CZ128298A3 (hu)
HR (1) HRP960494A2 (hu)
HU (1) HUP9902095A3 (hu)
PL (1) PL326428A1 (hu)
SK (1) SK51198A3 (hu)
WO (1) WO1997015573A1 (hu)
YU (1) YU56596A (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
WO1998018815A1 (en) * 1996-10-25 1998-05-07 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
ES2333097T3 (es) 2000-05-31 2010-02-17 Raqualia Pharma Inc Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal.
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
WO2003087069A2 (en) 2002-04-09 2003-10-23 Eli Lilly And Company Dipeptidic growth hormone secretagogues
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
KR20090107088A (ko) 2007-02-09 2009-10-12 트랜자임 파르마 인크 거대고리 그렐린 수용체 조절제 및 이의 사용 방법
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL176993B1 (pl) * 1992-12-11 1999-08-31 Merck & Co Inc Nowe związki spiropiperydynowe oraz sposób ich wytwarzania

Also Published As

Publication number Publication date
SK51198A3 (en) 1998-11-04
KR19990067097A (ko) 1999-08-16
CA2235511A1 (en) 1997-05-01
AR004124A1 (es) 1998-09-30
YU56596A (sh) 1999-09-27
EP0863900A1 (en) 1998-09-16
MX9803316A (es) 1998-09-30
BR9610887A (pt) 1999-07-13
CZ128298A3 (cs) 1998-07-15
HUP9902095A3 (en) 2001-05-28
AU7468596A (en) 1997-05-15
HRP960494A2 (en) 1998-04-30
PL326428A1 (en) 1998-09-14
WO1997015573A1 (en) 1997-05-01
HUP9902095A2 (hu) 1999-10-28

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