CA2235511A1 - Process for the preparation of a growth hormone secretagogue - Google Patents
Process for the preparation of a growth hormone secretagogue Download PDFInfo
- Publication number
- CA2235511A1 CA2235511A1 CA002235511A CA2235511A CA2235511A1 CA 2235511 A1 CA2235511 A1 CA 2235511A1 CA 002235511 A CA002235511 A CA 002235511A CA 2235511 A CA2235511 A CA 2235511A CA 2235511 A1 CA2235511 A1 CA 2235511A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- acid
- amino
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US589895P | 1995-10-27 | 1995-10-27 | |
| US60/005,898 | 1995-10-27 | ||
| GBGB9602949.1A GB9602949D0 (en) | 1996-02-13 | 1996-02-13 | Process for the preparation of a growth hormone secretagogue |
| GB9602949.1 | 1996-02-13 | ||
| PCT/US1996/016954 WO1997015573A1 (en) | 1995-10-27 | 1996-10-23 | Process for the preparation of a growth hormone secretagogue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2235511A1 true CA2235511A1 (en) | 1997-05-01 |
Family
ID=26308687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002235511A Abandoned CA2235511A1 (en) | 1995-10-27 | 1996-10-23 | Process for the preparation of a growth hormone secretagogue |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0863900A1 (hu) |
| JP (1) | JPH11513984A (hu) |
| KR (1) | KR19990067097A (hu) |
| AR (1) | AR004124A1 (hu) |
| AU (1) | AU7468596A (hu) |
| BR (1) | BR9610887A (hu) |
| CA (1) | CA2235511A1 (hu) |
| CZ (1) | CZ128298A3 (hu) |
| HR (1) | HRP960494A2 (hu) |
| HU (1) | HUP9902095A3 (hu) |
| PL (1) | PL326428A1 (hu) |
| SK (1) | SK51198A3 (hu) |
| WO (1) | WO1997015573A1 (hu) |
| YU (1) | YU56596A (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
| WO1998018815A1 (en) * | 1996-10-25 | 1998-05-07 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| US6329342B1 (en) | 1997-08-19 | 2001-12-11 | Eli Lilly And Company | Treatment of congestive heart failure with growth hormone secretagogues |
| US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
| ES2333097T3 (es) | 2000-05-31 | 2010-02-17 | Raqualia Pharma Inc | Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal. |
| US7125840B2 (en) | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
| WO2003087069A2 (en) | 2002-04-09 | 2003-10-23 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| KR20090107088A (ko) | 2007-02-09 | 2009-10-12 | 트랜자임 파르마 인크 | 거대고리 그렐린 수용체 조절제 및 이의 사용 방법 |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL176993B1 (pl) * | 1992-12-11 | 1999-08-31 | Merck & Co Inc | Nowe związki spiropiperydynowe oraz sposób ich wytwarzania |
-
1996
- 1996-10-23 EP EP96936868A patent/EP0863900A1/en not_active Withdrawn
- 1996-10-23 HU HU9902095A patent/HUP9902095A3/hu unknown
- 1996-10-23 SK SK511-98A patent/SK51198A3/sk unknown
- 1996-10-23 CZ CZ981282A patent/CZ128298A3/cs unknown
- 1996-10-23 KR KR1019980703037A patent/KR19990067097A/ko not_active Application Discontinuation
- 1996-10-23 AU AU74685/96A patent/AU7468596A/en not_active Abandoned
- 1996-10-23 JP JP9516736A patent/JPH11513984A/ja active Pending
- 1996-10-23 CA CA002235511A patent/CA2235511A1/en not_active Abandoned
- 1996-10-23 BR BR9610887A patent/BR9610887A/pt not_active Application Discontinuation
- 1996-10-23 PL PL96326428A patent/PL326428A1/xx unknown
- 1996-10-23 WO PCT/US1996/016954 patent/WO1997015573A1/en not_active Application Discontinuation
- 1996-10-25 HR HR9602949.1A patent/HRP960494A2/hr not_active Application Discontinuation
- 1996-10-25 AR ARP960104931A patent/AR004124A1/es unknown
- 1996-10-25 YU YU56596A patent/YU56596A/sh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK51198A3 (en) | 1998-11-04 |
| KR19990067097A (ko) | 1999-08-16 |
| AR004124A1 (es) | 1998-09-30 |
| YU56596A (sh) | 1999-09-27 |
| EP0863900A1 (en) | 1998-09-16 |
| MX9803316A (es) | 1998-09-30 |
| JPH11513984A (ja) | 1999-11-30 |
| BR9610887A (pt) | 1999-07-13 |
| CZ128298A3 (cs) | 1998-07-15 |
| HUP9902095A3 (en) | 2001-05-28 |
| AU7468596A (en) | 1997-05-15 |
| HRP960494A2 (en) | 1998-04-30 |
| PL326428A1 (en) | 1998-09-14 |
| WO1997015573A1 (en) | 1997-05-01 |
| HUP9902095A2 (hu) | 1999-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |