JPH11511114A - 新規化合物と治療方法 - Google Patents
新規化合物と治療方法Info
- Publication number
- JPH11511114A JPH11511114A JP8531385A JP53138596A JPH11511114A JP H11511114 A JPH11511114 A JP H11511114A JP 8531385 A JP8531385 A JP 8531385A JP 53138596 A JP53138596 A JP 53138596A JP H11511114 A JPH11511114 A JP H11511114A
- Authority
- JP
- Japan
- Prior art keywords
- fifteen
- alkyl
- independently
- alkenyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000000034 method Methods 0.000 title claims description 48
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- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 125000005843 halogen group Chemical group 0.000 claims description 29
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 16
- 125000000304 alkynyl group Chemical group 0.000 claims description 16
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
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- NPUKDXXFDDZOKR-LLVKDONJSA-N etomidate Chemical compound CCOC(=O)C1=CN=CN1[C@H](C)C1=CC=CC=C1 NPUKDXXFDDZOKR-LLVKDONJSA-N 0.000 claims description 7
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- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 5
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- XZLIYCQRASOFQM-UHFFFAOYSA-N 5h-imidazo[4,5-d]triazine Chemical compound N1=NC=C2NC=NC2=N1 XZLIYCQRASOFQM-UHFFFAOYSA-N 0.000 claims description 2
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- 125000004423 acyloxy group Chemical group 0.000 claims description 2
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- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 2
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- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract description 3
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
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- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 9
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 125000005458 thianyl group Chemical group 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
- 229960004231 thymalfasin Drugs 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 229940100615 topical ointment Drugs 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
- 125000001701 trimethoxybenzyl group Chemical group 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- HDZZVAMISRMYHH-LITAXDCLSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O HDZZVAMISRMYHH-LITAXDCLSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 150000007968 uric acids Chemical class 0.000 description 1
- AUFUWRKPQLGTGF-FMKGYKFTSA-N uridine triacetate Chemical compound CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H](COC(=O)C)O[C@H]1N1C(=O)NC(=O)C=C1 AUFUWRKPQLGTGF-FMKGYKFTSA-N 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 229960003636 vidarabine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. ヘルペスウイルスに感染したまたは感染のおそれのある被験体を、治療的 に受容可能な用量の以下の構造(1)を有する化合物および治療的に受容可能なそ れらの塩により処置する工程を包含する方法であって: ここで、 Yは、独立して、OH、-OR3、-OCH(R16)OC(O)R3、モノホスフェート、ジホスフ ェート、アミノ酸アミデート、ポリペプチドアミデート、-NHR3、または-N(R3)2 であり; R3は、独立して、非置換の、C1-C15アルキル、アリール、C2-C15アルケニル、 C2-C15アルキニル、アルカリール、アルキニルアリール、またはアルケニルアリ ールであり;R3は、独立して、アルキル、アリール、アルケニル、アルキニル、 アルカリール、アルキニルアリール、またはアルケニルアリール(これらはいず れもC1-6アルコキシ、C1-C6カルボキシルアルキルエステル、ハロ、カルボキシ 、ヒドロキシル、シアノ、ニトロ、N-モルホリノ、またはアミノで置換されてい る)であり;および/または、R3は、独立して、アルキル、アリール、アルケニ ル、アルキニル、アルカリール、アルキニルアリール、またはアルケニルアリー ル(これらはいずれも-CH2-がNH、S、またはOで置換されている)であり; R2'およびR2は、独立して、ハロ、NH2、XまたはHであるが、少なくとも1つ のR2はXであり; R1はCH3、C≡CH、CH=CH2、CH2F またはアジドメチルであり; R16は、HまたはR3であり;および Xは、-(CH2)m(O)n(CH2)mN(R10)2であり、ここで、m は 0-2、n は 0-1、そし てR10は独立して H、 C1-C15アルキル、C2-C15アルケニル、C6-C15アリールアルケニル、C6-C15 アリールアルキニル、C2-C15アルキニル、C1-C6-アルキルアミノ-C1-C6アルキ ル、C5-C15アラルキル、C6-C15ヘテロアラルキル、C5-C6アリール、C2-C6ヘテロ シクロアルキル、 N6に隣接しないアルキル部分中のメチレンが-O-により置換された、C2- C15アルキル、C3-C15アルケニル、C6-C15アリールアルケニル、C3-C15アルキニ ル、C7-C15アリールアルキニル、C1-C6-アルキルアミノ-C1-C6アルキル、C5-C15 アラルキル、C6-C15ヘテロアルキル、またはC3-C6ヘテロシクロアルキルであり 、 必要に応じて両方のR10は、Nと共に連結して、1個または2個のNヘ テロ原子、さらに必要に応じて、OまたはSヘテロ原子を含有する飽和または不 飽和C2-C5ヘテロ環を形成するか、 あるいは、上記R10基の1つは1〜3個のハロ、CN または N3で置換さ れるが;少なくとも1個のR10基はHでない;そして ZはNまたはCHであり、ただし、ヘテロ環の核は、1つのZのみによりプリン と異なる; 方法。 2. 前記ウイルスがVZVであり、R1がCH3であり、YがOHまたはOR3であり、R2 はHであり、そしてXが: である、請求項1に記載の方法。 3. R1が(S)立体配置をとる、請求項1に記載の方法。 4. R2がHである、請求項1に記載の方法。 5. R1がCH3である、請求項1に記載の方法。 6. 1つのR10基がHではない、請求項1に記載の方法。 7. 両方のR10基ともHではない、請求項1に記載の方法。 8. 1つのR10がC3-C4シクロアルキルである、請求項1に記載の方法。 9. 1つのR10がC1-C6-アルキルアミノ-C1-C6-アルキルである、請求項1に記 載の方法。 10. 1つのR10がC2-C15アルケニルまたはC3-C15アルニキルである、請求項 1に記載の方法。 11. 1つのR10が である、請求項1に記載の方法。 12. R1が(R)立体配置をとるCH3である、請求項1に記載の方法。 13. R2がHである、請求項8に記載の方法。 14. R1がCH3である、請求項1に記載の方法。 15. 前記化合物が、9-(R)-(2-ホスホノメトキシプロピル)-6-エチルメチル アミノアデニン、9-(R)-(2-ホスホノメトキシプロピル)-6-アリルアミノアデニ ン、9-(R)-(2-ホスホノメトキシプロピル)-6-シクロプロピルアミノアデニン、9 -(R)-(2-ホスホノメトキシプロピル)-6-(2-ジメチルアミノエチル)アミノアデニ ン、または9-(R)-(2-ホスホノメトキシプロピル)-2-アミノ-6-(2-ジメチルアミ ノエチル)アミノアデニンである、請求項1に記載の方法。 16. 下記構造(2)を有する化合物および治療的に受容可能なそれらの塩: ここで、 Yは、独立して、OH、-OR3、-OCH(R16)OC(O)R3、モノホスフェート、ジホスフ ェート、アミノ酸アミデート、ポリペプチドアミデート、-NHR3、または-N(R3)2 であり; Xは、-(CH2)m(O)n(CH2)mN(R10)2であり、ここで m は0〜2、n は0〜1で あり、そして; ZはNまたはCHであり、ただし、ヘテロ環の核は、1つのZのみによりプリン と異なり; R3は、独立して、非置換の、C1-C15アルキル、アリール、C2-C15アルケニル、 C2-C15アルキニル、アルカリール、アルキニルアリール、またはアルケニルアリ ールであり;R3は、独立して、アルキル、アリール、アルケニル、アルキニル、 アルカリール、アルキニルアリール、またはアルケニルアリール(これらはいず れもC1-C6アルコキシ、C1-C6カルボキシルアルキルエステル、ハロ、カルボキシ 、ヒドロキシ、シアノ、ニトロ、N-モルホリノ、またはアミノで置換されている )であり;および/または、R3は、独立して、アルキル、アリール、アルケニル 、アルキニル、アルカリール、アルキニルアリール、またはアルケニルアリール (これらはいずれも-CH2-がNH、S、またはOで置換されている)であり; R2'およびR2は、独立してハロ、NH2、XまたはHであるが、少なくとも1つの R2はXであり; Eは、-(CH2)2-、-CH(CH3)CH2-、-CH(CH2F)CH2-、-CH(CH2OH)CH2-、-CH(CH=CH2 )CH2-、-CH(C≡CH)CH2-、-CH(CH2N3)CH2-、 -CH(R6)OCH(R6')-、-CH(R9)CH2O-、または-CH(R8)O-であり、ここで右側の結合 は、プリン、モノアザプリンまたはモノデアザプリンのヘテロ環の9位と連結し 、そしてYと-CH(CH2OH)CH2-のヒドロキシル基、R4、R6、R8、またはR9は連結し て、6員環を形成し; 破線は任意の結合を表し; R4およびR5は、独立して、ヒドロキシ、アミノであり、あるいはアシロキシ、 アルコキシ、アルキルチオ、アルキルアミノ、およびジアルキルアミノから選択 される、1〜5個の炭素原子を有する置換基であり; R6およびR6'は、独立して、H、C1-C6アルキル、C1-C6ヒドロキシアルキル、 またはC2-C7アルカノイルであり; R7は、独立して、H、C1-C6アルキル、または一緒になって -O- または-CH2- を形成し; R8は、H、C1-C6アルキル、C1-C6ヒドロキシアルキルまたはC1-C6ハロアルキ ルであり; R9は、H、ヒドロキシメチル、またはアシロキシメチルであり;そして R10は独立して H、 C1-C15アルキル、C2-C15アルケニル、C6-C15アリールアルケニル、C6-C15 アリールアルキニル、C2-C15アルキニル、C1-C6-アルキルアミノ-C1-C6アルキ ル、C5-C15アラルキル、C6-C15ヘテロアラルキル、C5-C6アリール、C2-C6ヘテロ シクロ アルキル、 N6に隣接しないアルキル部分中のメチレンが-O-により置換された、C2- C15アルキル、C3-C15アルケニル、C6-C15アリールアルケニル、C3-C15アルキニ ル、C7-C15アリールアルキニル、C1-C6-アルキルアミノ-C1-C6アルキル、C5-C15 アラルキル、C6-C15ヘテロアルキル、またはC3-C6ヘテロシクロアルキルであり 、 必要に応じて両方のR10は、Nと共に連結して、1個または2個のNヘ テロ原子、さらに必要に応じて、OまたはSヘテロ原子を含有する飽和または不 飽和C2-C5ヘテロ環を形成するか、 あるいは、上記R10基の1つは、1〜3個のハロ、CN または N3で置換 されるが;少なくとも1個のR10基はHでない; R16はHまたはR3であり; ただし、 (a) Eが-CH(CH3)CH2-であり、かつR2がNH2である場合、Xは、ジメチルアミ ノ、ブチルアミノ、シクロプロピルアミノ、シクロペンチルアミノ、シクロヘキ シルアミノ、ピロリジノ、ピペリジノ、モルホリノ、またはベンジルアミノのい ずれでもない; (b) Eが-CH(CH2OH)CH2-であり、かつR2がHである場合、Xは、ジメチルアミ ノ、N-メチル-N-エチルアミノ、またはジエチルアミノのいずれでもない; (c) Eが-(CH2)2-であり、かつR2がNH2である場合、Xは、C5-C7シクロアルキ ルアミノまたはジメチルアミノのいずれでもない。 17. 少なくとも1つのYがOR3であり、そしてR3がアリール、オルト-(C1-C6 アルコキシアリール)、-C6H4C(O)O(C1-C6アルキル)、または-OCH2OC(O)(C1-C6ア ルキルまたはアリール)である、請求項16に記載の化合物。 18. Eキラル炭素原子において、(R)または(S)立体配置を有する、請求項1 6に記載の化合物。 19. (R)立体配置を有する、請求項16に記載の化合物。 20. (S)立体配置を有する、請求項16に記載の化合物。 21. Eが-CH(CH3)CH2-であり、かつR2がNH2である場合、Xがアルキルアミ ノジアルキルアミノ、アラルキルアミノ、ヘテロアラルキルアミノ、アルコキシ アミノ、またはヘテロ環アミノのいずれでもない化合物をさらに除外する、請求 項16に記載の化合物。 22. Eが-CH(CH3)CH2-であり、かつR2がHまたはNH2である場合、Xがアル キルアミノ、ジアルキルアミノ、アラルキルアミノ、ヘテロアラルキルアミノ、 アルコキシアミノ、またはヘテロ環アミノのいずれでもない化合物をさらに除外 する、請求項16に記載の化合物。 23. R10が、置換されていないか、あるいは1〜3個のハロ、CN、またはN3 で置換されているC3-C8アルキニルまたはアルケニルである、請求項16に記載 の化合物。 24. R10が、-CH2CH=CH2、-CH(CH3)CH=CH2、-CH2C(CH3)=CH2、または-CH2CH= CH(CH3)である、請求項16に記載の化合物。 25. R10がC1-C15アルキルではない、請求項16に記載の化合物。 26. 1つのR10基がHではない、請求項16に記載の化合物。 27. 両方のR10基がHではない、請求項16に記載の化合物。 28. 前記Eが、-CH(CH3)CH2-、-CH(CH=CH2)CH2-、-CH(C≡CH)CH2、または-C H(CH2N3)CH2-である、請求項16に記載の化合物。 29. 治療的に有効量の請求項16に記載の化合物を被験体に投与する工程を 包含する、ウイルス感染処置のための方法。 30. 前記ウイルス感染がHSV-1、HSV-2、CMV、VZV、ワクシニアウイルス、ま たはHHV-6である、請求項29に記載の方法。 31. 免疫抑制を必要とする被験体を、治療的に有効な用量の以下の構造(1) を有する化合物および治療的に受容可能なそれらの塩により処置する工程を包含 する方法であって: ここで、 Yは、独立して、OH、-OR3、-OCH(R16)OC(O)R3、モノホスフェート、ジホスフ ェート、アミノ酸アミデート、ポリペプチドアミデート、-NHR3、または-N(R3)2 であり; R3は、独立して、非置換の、C1-C15アルキル、アリール、C2-C15アルケニル、 C2-C15アルキニル、アルカリール、アルキニルアリール、またはアルケニルアリ ールであり;R3は、独立して、アルキル、アリール、アルケニル、アルキニル、 アルカリール、アルキニルアリール、またはアルケニルアリール(これらはいず れもC1-C6アルコキシ、C1-C6カルボキシルアルキルエステル、ハロ、カルボキシ 、ヒドロキシル、シアノ、ニトロ、N-モルホリノ、またはアミノで置換されてい る)であり;および/または、R3は、独立して、アルキル、アリール、アルケニ ル、アルキニル、アルカリール、アルキニルアリール、またはアルケニルアリー ル(これらはいずれも-CH2-がNH、S、またはOで置換されている)であり; R2'およびR2は、独立して、ハロ、NH2、XまたはHであるが、少なくとも1つ のR2はXであり; R1は、H、CH3、C≡CH、CH=CH2、CH2F またはアジドメチルであり; R16は、HまたはR3であり;および Xは、-(CH2)m(O)n(CH2)mN(R10)2であり、ここで、m は 0-2、n は 0-1、そし てR10は独立して H、 C1-C15アルキル、C2-C15アルケニル、C6-C15アリールアルケニル、C6-C15 アリールアルキニル、C2-C15アルキニル、C1-C6-アルキルアミノ-C1-C6アルキ ル、C5-C15アラルキル、C6-C15ヘテロアラルキル、C5-C6アリール、C2-C6ヘテロ シクロアルキル、 N6に隣接しないアルキル部分中のメチレンが-O-により置換された、C2- C15アルキル、C3-C15アルケニル、C6-C15アリールアルケニル、C3-C15アルキニ ル、C7-C15アリールアルキニル、C1-C6-アルキルアミノ-C1-C6アルキル、C5-C15 アラルキル、C6-C15ヘテロアルキルまたはC3-C6ヘテロシクロアルキルであり、 必要に応じて両方のR10は、Nと共に連結して、1個または2個のNヘ テロ原子、さらに必要に応じて、OまたはSヘテロ原子を含有する飽和または不 飽和C2-C5ヘテロ環を形成するか、 あるいは、上記R10基の1つは1〜3個のハロ、CNまたはN3で置換され るが;少なくとも1個のR10基はHでない;そして ZはNまたはCHであり、ただし、ヘテロ環の核は、1つのZのみによりプリン と異なる; 方法。
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JP2011225615A (ja) * | 2005-04-08 | 2011-11-10 | Chimerix Inc | ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法 |
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DK0821690T3 (da) | 2012-09-10 |
US5977061A (en) | 1999-11-02 |
JP2007126473A (ja) | 2007-05-24 |
EP0821690A1 (en) | 1998-02-04 |
EP0821690B1 (en) | 2012-06-13 |
WO1996033200A1 (en) | 1996-10-24 |
AU5268696A (en) | 1996-11-07 |
JP4233111B2 (ja) | 2009-03-04 |
ES2392840T3 (es) | 2012-12-14 |
PT821690E (pt) | 2012-09-17 |
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