JPH11510478A - キノリジノン型化合物 - Google Patents

キノリジノン型化合物

Info

Publication number
JPH11510478A
JPH11510478A JP9501420A JP50142097A JPH11510478A JP H11510478 A JPH11510478 A JP H11510478A JP 9501420 A JP9501420 A JP 9501420A JP 50142097 A JP50142097 A JP 50142097A JP H11510478 A JPH11510478 A JP H11510478A
Authority
JP
Japan
Prior art keywords
fluoro
methyl
oxo
carboxylic acid
quinolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9501420A
Other languages
English (en)
Japanese (ja)
Inventor
チユー，ダニエル・テイー
リ，チユン
クーパー，カート・エス
フン，アンソニー・ケイ・エル
リー，チヨウク・エム
プラツトナー，ジエイコブ・ジエイ
マー，チエンクン
ワン，ウエイ−ポー
Original Assignee
アボツト・ラボラトリーズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アボツト・ラボラトリーズ filed Critical アボツト・ラボラトリーズ
Priority claimed from PCT/US1996/008891 external-priority patent/WO1996040000A1/en
Publication of JPH11510478A publication Critical patent/JPH11510478A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP9501420A 1995-06-06 1996-06-05 キノリジノン型化合物 Pending JPH11510478A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46915995A 1995-06-06 1995-06-06
US08/469,159 1995-06-06
US63811296A 1996-05-29 1996-05-29
US08/638,112 1996-05-29
PCT/US1996/008891 WO1996040000A1 (en) 1995-06-07 1996-06-05 Curable fiber composite stent and delivery system

Publications (1)

Publication Number Publication Date
JPH11510478A true JPH11510478A (ja) 1999-09-14

Family

ID=27042662

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9501420A Pending JPH11510478A (ja) 1995-06-06 1996-06-05 キノリジノン型化合物

Country Status (8)

Country Link
EP (1) EP0871628A1 (de)
JP (1) JPH11510478A (de)
KR (1) KR19990022524A (de)
AU (1) AU6153096A (de)
CA (1) CA2222322A1 (de)
IL (1) IL122296A0 (de)
MX (1) MX9709416A (de)
WO (1) WO1996039407A1 (de)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004522749A (ja) * 2001-02-02 2004-07-29 アストラゼネカ アクチボラグ ３，７−ジアザビシクロ［３．３．０］オクタンと心不整脈の治療におけるその使用
JP2010006742A (ja) * 2008-06-26 2010-01-14 Dic Corp フルオロクロマノール誘導体の製造方法
JP2010018540A (ja) * 2008-07-10 2010-01-28 Dic Corp フルオロフェノール誘導体の製造方法
WO2010122774A1 (ja) * 2009-04-20 2010-10-28 株式会社カネカ (１ｓ,６ｓ)または(１ｒ,６ｒ)-シス-２,８-ジアザビシクロ[４.３.０]ノナンおよびその中間体の製造法
JP2011057639A (ja) * 2009-09-11 2011-03-24 Ikutoku Gakuen 光学活性２−置換−３−アミノピペリジン誘導体および製造方法
JP2012162529A (ja) * 2003-09-22 2012-08-30 Janssen Pharmaceutica Nv ７−アミノアルキリデニル−複素環式キノロンおよびナフチリドン
JP2015508075A (ja) * 2012-02-10 2015-03-16 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002151A2 (en) 1996-07-12 1998-01-22 Leukosite, Inc. Chemokine receptor antagonists and methods of use therefor
US5693813A (en) * 1997-02-26 1997-12-02 Abbott Laboratories Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid
KR100241673B1 (ko) * 1997-08-09 2000-03-02 김충섭 퀴놀리진 카르복실산 유도체
AU735186B2 (en) 1997-09-15 2001-07-05 Warner Chilcott Company, Llc Antimicrobial quinolones, their compositions and uses
US6630488B1 (en) 1998-09-21 2003-10-07 Biochem Pharma, Inc. Quinolizinones as integrin inhibitors
DE69925859T2 (de) 1998-11-24 2006-05-11 Daiichi Pharmaceutical Co., Ltd. Cycloalkylsubstituierte aminomethylpyrrolidin-derivate
EP2275141A1 (de) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Geschmacksmaskierte pharmazeutische Zusammensetzungen
JP2003516988A (ja) 1999-12-14 2003-05-20 ニューロサーチ、アクティーゼルスカブ 新規ヘテロアリール−ジアザビシクロアルカン類
DE19962470A1 (de) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ATE404558T1 (de) * 2001-09-28 2008-08-15 Sato Pharma Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
EP1693364B1 (de) 2003-12-12 2015-05-20 Daiichi Sankyo Company, Limited Zwischenprodukte für die herstellung von optisch aktiven cyclopropylaminderivaten und verfahren zur herstellung der zwischenprodukte
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
KR101084521B1 (ko) 2006-03-28 2011-11-18 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
MX2008012328A (es) 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
MY162052A (en) * 2007-01-05 2017-05-31 Daiichi Sankyo Co Ltd Fused substitute aminopyrrolidine derivative
CN101622240B (zh) * 2007-01-05 2014-07-23 第一三共株式会社 稠合取代氨基吡咯烷衍生物
CA2707447C (en) 2007-12-26 2016-03-08 Banyu Pharmaceutical Co., Ltd. Sulfonyl-substituted 6-membered ring derivative
US8796297B2 (en) 2009-06-30 2014-08-05 Abbvie Inc. 4-substituted-2-amino-pyrimidine derivatives
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
JP5759470B2 (ja) 2009-10-23 2015-08-05 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての二置換オクタヒドロピロロ［３，４−ｃ］ピロール
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
EP3848035A1 (de) 2015-12-10 2021-07-14 PTC Therapeutics, Inc. 1,4-disubstituierte pyridazinverbindungen zur behandlung der huntington krankheit
KR102559922B1 (ko) 2016-03-10 2023-07-25 얀센 파마슈티카 엔.브이. 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
CN106543170B (zh) * 2016-10-27 2018-02-23 丹诺医药(苏州）有限公司 8‑氯‑1‑环丙基‑7‑氟‑9‑甲基‑4‑氧‑4‑氢‑喹嗪‑3‑羧酸酯及其合成方法
MX2019005588A (es) 2016-11-28 2019-10-15 Ptc Therapeutics Inc Metodos para modular corte y empalme de arn.
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
US11608501B2 (en) 2017-06-14 2023-03-21 Ptc Therapeutics, Inc. Methods for modifying RNA splicing
CA3067591A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
CA3067592A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
WO2019191092A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
JP7421507B2 (ja) 2018-06-27 2024-01-24 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するためのヘテロ環式およびヘテロアリール化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0527889B1 (de) * 1990-05-02 2000-08-02 Abbott Laboratories Verbindungen vom chinolizinon-typ
AU689809B2 (en) * 1993-10-14 1998-04-09 Abbott Laboratories Quinolizinone type compounds

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004522749A (ja) * 2001-02-02 2004-07-29 アストラゼネカ アクチボラグ ３，７−ジアザビシクロ［３．３．０］オクタンと心不整脈の治療におけるその使用
JP2012162529A (ja) * 2003-09-22 2012-08-30 Janssen Pharmaceutica Nv ７−アミノアルキリデニル−複素環式キノロンおよびナフチリドン
JP2010006742A (ja) * 2008-06-26 2010-01-14 Dic Corp フルオロクロマノール誘導体の製造方法
JP2010018540A (ja) * 2008-07-10 2010-01-28 Dic Corp フルオロフェノール誘導体の製造方法
WO2010122774A1 (ja) * 2009-04-20 2010-10-28 株式会社カネカ (１ｓ,６ｓ)または(１ｒ,６ｒ)-シス-２,８-ジアザビシクロ[４.３.０]ノナンおよびその中間体の製造法
JP2011057639A (ja) * 2009-09-11 2011-03-24 Ikutoku Gakuen 光学活性２−置換−３−アミノピペリジン誘導体および製造方法
JP2015508075A (ja) * 2012-02-10 2015-03-16 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
JP2017122097A (ja) * 2012-02-10 2017-07-13 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物

Also Published As

Publication number Publication date
AU6153096A (en) 1996-12-24
IL122296A0 (en) 1998-04-05
KR19990022524A (ko) 1999-03-25
EP0871628A1 (de) 1998-10-21
CA2222322A1 (en) 1996-12-12
MX9709416A (es) 1998-07-31
WO1996039407A1 (en) 1996-12-12

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