JPH11504936A - プランタラム乳酸桿菌およびアルギニンを含む薬学的組成物 - Google Patents
プランタラム乳酸桿菌およびアルギニンを含む薬学的組成物Info
- Publication number
- JPH11504936A JPH11504936A JP8533997A JP53399796A JPH11504936A JP H11504936 A JPH11504936 A JP H11504936A JP 8533997 A JP8533997 A JP 8533997A JP 53399796 A JP53399796 A JP 53399796A JP H11504936 A JPH11504936 A JP H11504936A
- Authority
- JP
- Japan
- Prior art keywords
- plantarum
- lactobacillus
- arginine
- pharmaceutical composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61P31/04—Antibacterial agents
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. −インビボでヒト腸粘膜にコロニー形成する能力を有するプランタラム乳 酸桿菌(Lactobacillus plantarum)株; −アルギニン;および −薬学的に許容される担体、 を含む薬学的組成物。 2. プランタラム乳酸桿菌株がヒト腸上皮細胞上のレセプターに接着性を賦与 するアドヘシンを有するものである、請求項1に記載の薬学的組成物。 3. 乳酸桿菌株が、ピアソン乗積相関係数および算術平均を用いる不荷重対群 アルゴリズム(UPGMA;ゲルコムパー(GelCompare)3.0、アプライド・マスズ、コ ルトリジク、ベルギー)を用いて、プランタラム乳酸桿菌株299、寄託番号 DSM 6595との制限エンドヌクレアーゼ分析による類似性が70%より高いクラスターに 属するプランタラム乳酸桿菌株である、請求項1または2に記載の薬学的組成物 。 4. プランタラム乳酸桿菌株がプランタラム乳酸桿菌299、DSM 6595、および プランタラム乳酸桿菌299v、DSM 9843からなる群から選択される、請求項1〜3 のいずれかに記載の薬学的組成物。 5. アルギニンがL-アルギニンである請求項1〜4のいずれかに記載の薬学 的組成物。 6. 経口または経直腸投与のための請求項1〜5のいずれかに記載の薬学的組 成物。 7. ヒトを含む哺乳動物の急性肝臓傷害および不全ならびに関連する細菌移動 の処置のための請求項1〜6のいずれかに記載の薬学的組成物。 8. 請求項1〜6のいずれかに記載の薬学的組成物の治療的有効量を投与する ことを包含するヒトを含む哺乳動物の肝臓傷害および不全ならびに関連する細菌 移動の治療的および/または予防的処置の方法。 9. プランタラム乳酸桿菌の菌株およびアルギニンの組合せを含む、治療に使 用するための組成物。 10. ヒトを含む哺乳動物の肝臓傷害および不全ならびに関連する細菌移動の 治療的および/または予防的処置のための医薬製造における請求項1〜6および 9のいずれかに記載の組成物の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9501719-0 | 1995-05-09 | ||
SE9501719A SE9501719D0 (sv) | 1995-05-09 | 1995-05-09 | Pharmaceutical composition |
PCT/SE1996/000603 WO1996035440A1 (en) | 1995-05-09 | 1996-05-08 | Pharmaceutical composition comprising lactobacillus plantarum and arginine |
Publications (2)
Publication Number | Publication Date |
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JPH11504936A true JPH11504936A (ja) | 1999-05-11 |
JP4058560B2 JP4058560B2 (ja) | 2008-03-12 |
Family
ID=20398250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP53399796A Expired - Fee Related JP4058560B2 (ja) | 1995-05-09 | 1996-05-08 | ラクトバチルス プランタラムおよびアルギニンを含む薬学的組成物 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0825869B1 (ja) |
JP (1) | JP4058560B2 (ja) |
KR (1) | KR19990008403A (ja) |
CN (1) | CN1152678C (ja) |
AT (1) | ATE221783T1 (ja) |
AU (1) | AU704886B2 (ja) |
BR (1) | BR9608284A (ja) |
CA (1) | CA2220498A1 (ja) |
DE (2) | DE825869T1 (ja) |
EE (1) | EE03597B1 (ja) |
ES (1) | ES2112818T3 (ja) |
GR (1) | GR980300028T1 (ja) |
NO (1) | NO317668B1 (ja) |
PL (1) | PL184603B1 (ja) |
SE (1) | SE9501719D0 (ja) |
WO (1) | WO1996035440A1 (ja) |
Cited By (5)
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WO2005094848A1 (ja) * | 2004-03-31 | 2005-10-13 | Calpis Co., Ltd. | 肝障害予防又は抑制剤及び肝障害予防又は抑制用機能性食品 |
WO2009099139A1 (ja) * | 2008-02-08 | 2009-08-13 | Hiroshima University | 肝機能改善剤およびその製造用ツール、ならびにこれらの利用 |
WO2010064434A1 (ja) * | 2008-12-03 | 2010-06-10 | 国立大学法人広島大学 | 肝機能障害予防剤 |
JP2014047212A (ja) * | 2012-08-29 | 2014-03-17 | China Medical Univ | ラクトバチラス‐プランタルムcmu995菌株の使用方法 |
JP2015163643A (ja) * | 2005-09-28 | 2015-09-10 | ノルディスク リバランス アクティーゼルスカブ | 治療エフェクターとしてプロバイオティック細菌と発酵穀物を用いるibd及びibsの治療 |
Families Citing this family (14)
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KR100376954B1 (ko) * | 1995-07-31 | 2003-07-18 | 프로비 에이비 | 장에서집락화하는유산간균 |
BR0109496A (pt) | 2000-03-24 | 2002-12-10 | Nestle Sa | Uso de bactéria do ácido láctico para o tratamento de peritonite |
KR100585391B1 (ko) * | 2002-01-24 | 2006-06-01 | 주식회사 프로바이오닉 | 돼지 전염성위장염 (TGE) 코로나바이러스 및 유해 미생물 억제 활성을 갖는 신규 락토바실러스 프란타럼 Probio-38 및 이를 함유하는 생균활성제 |
SE527555C2 (sv) * | 2003-04-04 | 2006-04-11 | Probi Ab | Anti-inflammatorisk komposition innehållande tannasproducerande Lactobacillusstammar |
KR100592717B1 (ko) * | 2004-11-20 | 2006-06-26 | 주식회사 알엔에이 | 간 손상 보호 및 예방에 유용한 활성을 갖는 조성물 |
CN1322111C (zh) * | 2004-12-17 | 2007-06-20 | 上海交大昂立股份有限公司 | 一种植物乳杆菌 |
CN100337653C (zh) * | 2004-12-21 | 2007-09-19 | 上海交大昂立股份有限公司 | 一种含有植物乳杆菌的组合物 |
KR101075557B1 (ko) | 2008-12-03 | 2011-10-20 | 씨제이제일제당 (주) | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
KR101075558B1 (ko) * | 2008-12-03 | 2011-10-20 | 씨제이제일제당 (주) | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
KR101255050B1 (ko) | 2009-07-14 | 2013-04-16 | 씨제이제일제당 (주) | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
KR101486999B1 (ko) * | 2009-07-22 | 2015-01-28 | 씨제이제일제당 주식회사 | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
CN102618456B (zh) * | 2012-02-28 | 2013-08-21 | 江南大学 | 一种能够缓解慢性酒精性肝损伤的鼠李糖乳杆菌及其用途 |
JP7136807B2 (ja) | 2017-04-17 | 2022-09-13 | ザ・ユニバーシティ・オブ・シカゴ | ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料 |
WO2023104887A1 (en) * | 2021-12-09 | 2023-06-15 | Société des Produits Nestlé S.A. | Lactobacillus acidophilus to increase agmatine production by microbiota |
-
1995
- 1995-05-09 SE SE9501719A patent/SE9501719D0/xx unknown
-
1996
- 1996-05-08 DE DE0825869T patent/DE825869T1/de active Pending
- 1996-05-08 BR BR9608284A patent/BR9608284A/pt not_active IP Right Cessation
- 1996-05-08 KR KR1019970707930A patent/KR19990008403A/ko not_active Application Discontinuation
- 1996-05-08 DE DE69622855T patent/DE69622855T2/de not_active Expired - Fee Related
- 1996-05-08 AU AU57846/96A patent/AU704886B2/en not_active Ceased
- 1996-05-08 EP EP96914505A patent/EP0825869B1/en not_active Expired - Lifetime
- 1996-05-08 CA CA002220498A patent/CA2220498A1/en not_active Abandoned
- 1996-05-08 WO PCT/SE1996/000603 patent/WO1996035440A1/en active IP Right Grant
- 1996-05-08 AT AT96914505T patent/ATE221783T1/de not_active IP Right Cessation
- 1996-05-08 PL PL96323320A patent/PL184603B1/pl not_active IP Right Cessation
- 1996-05-08 ES ES96914505T patent/ES2112818T3/es not_active Expired - Lifetime
- 1996-05-08 JP JP53399796A patent/JP4058560B2/ja not_active Expired - Fee Related
- 1996-05-08 CN CNB961953993A patent/CN1152678C/zh not_active Expired - Fee Related
- 1996-05-08 EE EE9700269A patent/EE03597B1/xx not_active IP Right Cessation
-
1997
- 1997-11-07 NO NO19975136A patent/NO317668B1/no not_active Application Discontinuation
-
1998
- 1998-04-30 GR GR980300028T patent/GR980300028T1/el unknown
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005094848A1 (ja) * | 2004-03-31 | 2005-10-13 | Calpis Co., Ltd. | 肝障害予防又は抑制剤及び肝障害予防又は抑制用機能性食品 |
JP2015163643A (ja) * | 2005-09-28 | 2015-09-10 | ノルディスク リバランス アクティーゼルスカブ | 治療エフェクターとしてプロバイオティック細菌と発酵穀物を用いるibd及びibsの治療 |
WO2009099139A1 (ja) * | 2008-02-08 | 2009-08-13 | Hiroshima University | 肝機能改善剤およびその製造用ツール、ならびにこれらの利用 |
JP2009184998A (ja) * | 2008-02-08 | 2009-08-20 | Hiroshima Univ | 肝機能改善剤およびその製造用ツール、ならびにこれらの利用 |
WO2010064434A1 (ja) * | 2008-12-03 | 2010-06-10 | 国立大学法人広島大学 | 肝機能障害予防剤 |
JP5823695B2 (ja) * | 2008-12-03 | 2015-11-25 | 国立大学法人広島大学 | 肝機能障害予防剤 |
JP2014047212A (ja) * | 2012-08-29 | 2014-03-17 | China Medical Univ | ラクトバチラス‐プランタルムcmu995菌株の使用方法 |
Also Published As
Publication number | Publication date |
---|---|
PL184603B1 (pl) | 2002-11-29 |
NO975136L (no) | 1997-11-07 |
CN1190346A (zh) | 1998-08-12 |
JP4058560B2 (ja) | 2008-03-12 |
WO1996035440A1 (en) | 1996-11-14 |
PL323320A1 (en) | 1998-03-16 |
EP0825869B1 (en) | 2002-08-07 |
ES2112818T1 (es) | 1998-04-16 |
DE69622855T2 (de) | 2003-04-10 |
EE9700269A (et) | 1998-04-15 |
NO317668B1 (no) | 2004-11-29 |
KR19990008403A (ko) | 1999-01-25 |
DE69622855D1 (de) | 2002-09-12 |
ES2112818T3 (es) | 2003-02-16 |
GR980300028T1 (en) | 1998-04-30 |
CA2220498A1 (en) | 1996-11-14 |
BR9608284A (pt) | 1999-06-08 |
EP0825869A1 (en) | 1998-03-04 |
DE825869T1 (de) | 1998-07-16 |
ATE221783T1 (de) | 2002-08-15 |
AU5784696A (en) | 1996-11-29 |
NO975136D0 (no) | 1997-11-07 |
EE03597B1 (et) | 2002-02-15 |
CN1152678C (zh) | 2004-06-09 |
SE9501719D0 (sv) | 1995-05-09 |
AU704886B2 (en) | 1999-05-06 |
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